316 | id == 316
316 | category_id == 19
316 | category_order == 16
316 | category_name == Pain
316 | category_color == #C47AC0
316 | slug == IL17A-response-to-painkillers
316 | title == Does this Pro-Inflammation Gene Affect Your Response to Painkillers? (IL-17A)
316 | meta_description == IL17A is associated with your response to painkillers. Click here for some diet and gene-based tips!
316 | summary == <p style="text-align:justify"><strong>The IL17A gene encodes IL17A, a molecule that can cause inflammation. Variants of IL17A have been associated with requiring higher amounts of drugs to treat pain. Read on to learn more!</strong></p>
316 | overall_score_text == Your overall score
316 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL17a--Pain-Resp.-to-Painkillers.jpg
316 | author_id == 15
316 | author_name == John Williams
316 | author_title == B.Sc
316 | author_order == 3987
316 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/sinan_pic.png
316 | author_intro == <p>John received his BSc from the University of Toronto.&nbsp;John has spent the last several years teaching high school science and math to English-language learners, which has forced him to learn how to simplify difficult concepts as much as possible. He has also worked in two different research labs and has experience as a student intern working and studying under doctors in hospitals and clinics to help diagnose and treat patients, interpret lab results and fill out mountains of paperwork.</p>
316 | reviewer == None
316 | medical_reviewer_id == 11
316 | medical_reviewer_name == Puya Yazdi
316 | medical_reviewer_title == MD
316 | publish_date == 2020
316 | publish_date == 9
316 | publish_date == 8
316 | avg_rating == 5.0
316 | tags_id == 349
316 | tags_name == IL17A gene
316 | tags_id == 598
316 | tags_name == Opioids
316 | tags_id == 653
316 | tags_name == Response to Painkillers
316 | permissions_favorite == False
316 | permissions_rate == False
316 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">IL-17A is an inflammatory cytokine, which increases inflammation in the body.<br /><br />Certain variants produce more IL-17A, leading to greater amounts of inflammation and therefore requiring you to take more painkillers to relieve pain. <br /><br /><span>Lifestyle, diet, and supplement modifications can counteract the effects of these variants by either directly reducing the amount of IL-17A in your body or reducing the number of Th17 cells, the main type of cell that produces IL-17A</span><span>.</span></span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>IL-17A and Response to Painkillers</strong></h2> <p><span style="font-weight: 400;">IL-17A is a cytokine. It is released mainly by Th17 cells, a kind of immune cell, and is one of the causes of inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30106258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <p><span style="font-weight: 400;">Some variants of the SNP </span><a href="https://selfdecode.com/snp/rs2275913/"><strong>rs2275913</strong></a><span style="font-weight: 400;"> result in more IL-17A being produced. This leads to more inflammation and, consequently, a greater amount of painkillers may be needed in order to relieve pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22028838/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30106258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your IL-17A Results for Response to Painkillers</strong></h2> <h4 style="text-align: justify;">*6502615623175898*</h4> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong>IL17A </strong><a href="https://selfdecode.com/snp/rs2275913/"><strong>rs2275913</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = increased levels of IL-17A; associated with requiring a higher amount of painkillers to relieve pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = normal levels of iL-17A; no association with painkiller dose required for pain relief</span></li> </ul> <p style="text-align: justify;"><strong>*2812217129884053*</strong></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>Recommendations for Reducing IL-17A Levels</strong></h2> <p style="text-align: justify;"><em><span style="font-weight: 400;"><strong>*3420903818299423*</strong></span></em></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Reduce Stress</strong></h4> <p><span style="font-weight: 400;">Researchers found a strong association between stress levels (as measured by questionnaires) and levels of IL-17A in the body. This association seemed to be stronger in non-Caucasians [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <p><span style="font-weight: 400;">Mindfulness-based stress reduction was found to reduce both pain levels and painkiller requirements in patients that had undergone back surgery [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21135196/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Probiotics</strong></h4> <p><a href="https://selfhacked.com/blog/a1probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotics</span></a><span style="font-weight: 400;"> are &lsquo;good&rsquo; bacteria that live in your gut and can have a significant impact on your overall health. You can find them naturally in fermented products like yogurt, kefir, cabbage and sauerkraut [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27246320"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Post-surgery patients with colorectal cancer that were given a mix of probiotics including </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">Bifidobacterium</span></em><span style="font-weight: 400;"> were found to have lower IL-17a levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31340751/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. </span></p> <p>Patients with lower back pain who took probiotics for a full year reported a small decrease in pain severity compared to those who didn&rsquo;t [<a href="https://pubmed.ncbi.nlm.nih.gov/31309333/">R</a>].</p>
316 | content_snp_table_6502615623175898_key == 6502615623175898
316 | content_snp_table_6502615623175898_blur == True
316 | content_snp_table_6502615623175898_hidden == False
316 | content_learn_more_2812217129884053_key == 2812217129884053
316 | content_learn_more_2812217129884053_blur == True
316 | content_learn_more_2812217129884053_hidden == False
316 | content_learn_more_2812217129884053_text == Based on the variants we looked at, your IL-17A gene makes you somewhat more likely to require additional painkillers to treat pain. However, this doesn't necessarily reflect your overall response to painkillers; it’s just one gene related to it. Dietary changes, stress reduction, and probiotics may help. Keep scrolling to find out more.
316 | content_recommendation_3420903818299423_key == 3420903818299423
316 | content_recommendation_3420903818299423_blur == True
316 | content_recommendation_3420903818299423_hidden == False
rsIDs = rs2275913
rsStatus = rs2275913,IL17A,chr6,52186235,G,A,C,,31,0,Normal
