318 | id == 318
318 | category_id == 20
318 | category_order == 17
318 | category_name == Attention
318 | category_color == #C47AC0
318 | slug == HTR2A-serotonin-ADHD
318 | title == Genetic Link Between ADHD and Serotonin (HTR2A)
318 | meta_description == The HTR2A gene enables serotonin to enhance attention & cognition. Learn about its link with ADHD.
318 | summary == <p style="text-align:justify"><strong>Did you know that serotonin is crucial for attention and other cognitive functions? The HTR2A gene helps produce a crucial serotonin receptor &mdash; read this post to learn about its link with ADHD.</strong></p>
318 | overall_score_text == Your ADHD Score (Based on HTR2A Gene)
318 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HTR2A-ADHD.jpg
318 | author_id == 9
318 | author_name == Aleksa Ristic
318 | author_title == MS (Pharmacy)
318 | author_order == 45
318 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
318 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
318 | reviewer == None
318 | medical_reviewer_id == 11
318 | medical_reviewer_name == Puya Yazdi
318 | medical_reviewer_title == MD
318 | publish_date == 2020
318 | publish_date == 9
318 | publish_date == 9
318 | avg_rating == 5.0
318 | tags_id == 673
318 | tags_name == 5-HT2A receptor
318 | tags_id == 30
318 | tags_name == ADHD
318 | tags_id == 56
318 | tags_name == Attention
318 | tags_id == 692
318 | tags_name == Cannabinoids
318 | tags_id == 13
318 | tags_name == Cognition
318 | tags_id == 207
318 | tags_name == Exercise
318 | tags_id == 672
318 | tags_name == HTR2A gene
318 | tags_id == 309
318 | tags_name == Serotonin
318 | permissions_favorite == False
318 | permissions_rate == False
318 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The HTR2A gene helps produce a serotonin receptor, 5-HT2A, crucial for attention and other cognitive functions.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>HTR2A gene variants correlate with higher odds of ADHD. They may impair serotonin signaling in the brain via 5-HT2A receptors.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific lifestyle changes and supplements may improve the symptoms of ADHD by targeting HTR2A variants.</strong></span></p> <h2><strong>The HTR2A Gene &amp; Attention</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../article/dating-success-genes-5"><span style="font-weight: 400;">HTR2A</span></a><span style="font-weight: 400;"> gene helps produce a </span><a href="https://www.selfhacked.com/blog/how-to-increase-serotonin"><span style="font-weight: 400;">serotonin</span></a><span style="font-weight: 400;"> receptor, 5-HT2A [</span><a href="https://ghr.nlm.nih.gov/gene/HTR2A"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This receptor is crucial for </span><a href="https://selfhacked.com/blog/focus-attention-improve/"><span style="font-weight: 400;">attention</span></a><span style="font-weight: 400;"> and other cognitive functions, but its role in ADHD is still being studied [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21320838/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10357515"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">ADHD is associated with lower serotonin levels in the brain and blood [</span><a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0447.1999.tb07229.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1143984/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20921119/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/5ht2a-receptors-a-root-cause-of-anxiety-fatigue-sleep-problems-and-cirs/"><span style="font-weight: 400;">Read this post</span></a><span style="font-weight: 400;"> to learn more about the 5-HT2A receptor roles in mental health, </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;">, cognition, and more.</span></p> <h2><strong>Your HTR2A Results for ADHD</strong></h2> <p>*6592850262315377*</p> <p><strong>Primary SNP:</strong></p> <p><strong><em>HTR2A</em></strong> <a href="../../../snp/rs7984966/"><strong>rs7984966</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/17938636/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span><strong>&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of ADHD in adults&nbsp;</span></li> </ul> <p><strong>Other important SNP:</strong></p> <p><strong><em>HTR2A</em></strong> <a href="../../../snp/rs7322347/"><strong>rs7322347</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/17938636/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span><strong>&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of ADHD in children</span></li> </ul> <p><span style="font-weight: 400;">These variants likely impair serotonin signaling in the brain via 5-HT2A receptors, contributing to cognitive and attention disorders [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21320838/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p>*9506201334474784*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Attention</strong></h2> <p>*3914010337512863*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Regular aerobic</span><a href="https://selfhacked.com/blog/2016/09/21/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;"> exercise</span></a><span style="font-weight: 400;"> improved attention deficit and other ADHD symptoms in multiple clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372555/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724411/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Exercise boosts serotonin in the brain and increases the activity of 5-HT2A receptors [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11310929/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8153173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Cannabinoids</strong></h4> <p><a href="https://selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/"><span style="font-weight: 400;">Cannabinoids</span></a><span style="font-weight: 400;"> can increase brain serotonin levels and activate 5-HT2A receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552103/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277878/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Medical cannabis is popular among ADHD patients and may reduce drug use [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882033/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">An product containing <a href="https://selfhacked.com/blog/cannabidiol-cbd/">CBD</a> and<a href="https://selfhacked.com/blog/tetrahydrocannabinol-thc/"> THC</a> (Sativex) slightly improved inattention and other ADHD symptoms in one clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28576350"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/top-6-unique-super-effective-ways-counteract-negative-performance-effects-cannabismarijuana/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">Cannabis</span></a><span style="font-weight: 400;"> use for ADHD lacks stronger clinical evidence, and some users may experience worsening of their symptoms &mdash; caution is warranted [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28576350"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840066/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Additionally, medical cannabis may not be legal in your country.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cannabinoids may help improve ADHD by targeting your gene variants, but the research is inconclusive. Avoid using cannabis unless prescribed by a doctor and make sure it's legal in your country.</span></p>
318 | content_snp_table_6592850262315377_key == 6592850262315377
318 | content_snp_table_6592850262315377_blur == True
318 | content_snp_table_6592850262315377_hidden == False
318 | content_learn_more_9506201334474784_key == 9506201334474784
318 | content_learn_more_9506201334474784_blur == True
318 | content_learn_more_9506201334474784_hidden == False
318 | content_learn_more_9506201334474784_text == Based on the variants we looked at, your HTR2A gene is associated with slightly higher odds of ADHD. However, this doesn't necessarily reflect your overall risk of ADHD, just one gene related to it. Regular exercise may improve ADHD symptoms by targeting your gene variants. Keep reading to learn more.
318 | content_recommendation_3914010337512863_key == 3914010337512863
318 | content_recommendation_3914010337512863_blur == True
318 | content_recommendation_3914010337512863_hidden == False
rsIDs = rs7984966,rs7322347
rsStatus = rs7984966,HTR2A,chr13,46855311,T,A,C,,24,0,Normal
rsStatus = rs7322347,HTR2A,chr13,46835968,T,A,,,4,20,HET
