319 | id == 319
319 | category_id == 20
319 | category_order == 17
319 | category_name == Attention
319 | category_color == #C47AC0
319 | slug == TPH2-ADHD
319 | title == Does This Gene Affect Your Risk of ADHD? (TPH2)
319 | meta_description == TPH2 is associated with ADHD. Click here for some diet and gene-based tips!
319 | summary == <p style="text-align:justify"><strong>The TPH2 gene is needed to make serotonin, a molecule associated with ADHD. Variants of TPH2 are associated with less serotonin production. Read on to find out if this is you and get some recommendations!</strong></p>
319 | overall_score_text == Your ADHD Score (based on TPH2)
319 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/tph2.jfif
319 | author_id == 15
319 | author_name == John Williams
319 | author_title == B.Sc
319 | author_order == 3987
319 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/sinan_pic.png
319 | author_intro == <p>John received his BSc from the University of Toronto.&nbsp;John has spent the last several years teaching high school science and math to English-language learners, which has forced him to learn how to simplify difficult concepts as much as possible. He has also worked in two different research labs and has experience as a student intern working and studying under doctors in hospitals and clinics to help diagnose and treat patients, interpret lab results and fill out mountains of paperwork.</p>
319 | reviewer == None
319 | medical_reviewer_id == 11
319 | medical_reviewer_name == Puya Yazdi
319 | medical_reviewer_title == MD
319 | publish_date == 2020
319 | publish_date == 9
319 | publish_date == 9
319 | avg_rating == 5.0
319 | tags_id == 30
319 | tags_name == ADHD
319 | tags_id == 309
319 | tags_name == Serotonin
319 | tags_id == 693
319 | tags_name == TPH2 gene
319 | tags_id == 694
319 | tags_name == Tryptophan
319 | permissions_favorite == False
319 | permissions_rate == False
319 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em>TPH2 </em>encodes tryptophan hydroxylase 2, a protein used to make serotonin in the brain.<br /><br />Some variants of <em>TPH2 </em>are associated with an increased risk of ADHD or increased ADHD severity. This is because they produce less TPH2 protein, which is needed to make serotonin.<br /><br />Lifestyle, diet, and supplement modifications can counteract the effects of these variants by either increasing serotonin levels directly, increasing tryptophan levels so that more serotonin can be made or making it easier for tryptophan to enter the brain.</span></strong></p> <h2 style="text-align: justify;"><strong><em>TPH2</em> and ADHD</strong></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">TPH2</span></em><span style="font-weight: 400;"> gene encodes the protein tryptophan hydroxylase 2. This protein helps turn tryptophan into serotonin in the brain.&nbsp;</span></p> <p><span style="font-weight: 400;">Some variants result in less serotonin being produced. Low serotonin levels are associated with ADHD and ADHD-like symptoms. [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15940290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9066992/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9693387/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22262065/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <h2 style="text-align: justify;"><strong>Your <em>TPH2</em> Results for ADHD</strong></h2> <h3 style="text-align: justify;">*6000482455087799*</h3> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>TPH2</em></strong><strong>&nbsp;</strong><a href="https://selfdecode.com/snp/rs1843809/"><strong>rs1843809</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/15940290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23461725/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with increased risk of ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with ADHD risk</span><span style="font-weight: 400;"><br /><br /></span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs:</strong></p> <p style="text-align: justify;"><strong><em>TPH2</em></strong><strong>&nbsp;</strong><a href="https://selfdecode.com/snp/rs1386497/"><strong>rs1386497</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with increased risk of ADHD&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with ADHD risk</span></li> </ul> <p style="text-align: justify;"><strong><em>TPH2 </em></strong><a href="https://selfdecode.com/snp/rs11179027/"><strong>rs11179027</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with increased risk of ADHD&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with ADHD risk</span></li> </ul> <p style="text-align: justify;"><strong><em>TPH2 </em></strong><a href="http://selfdecode.com/snp/rs4570625/"><strong>rs4570625</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/18427560/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with increased severity of ADHD symptoms&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with increased severity of ADHD symptoms</span></li> </ul> <p style="text-align: justify;"><strong>*5635189884287555*</strong></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>Recommendations for Improving ADHD</strong></h2> <p style="text-align: justify;"><strong>*7742022664185424*</strong></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Exercise increases tryptophan in the brain -- since tryptophan is needed to make serotonin, that should boost serotonin levels as well [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25126826/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16218925/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Exercise should be performed on a regular basis to obtain its proper benefit.</span></p> <p><span style="font-weight: 400;">Exercise has been associated with reduced ADHD symptoms in children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25803290/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25561359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31212854/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24621460/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] and is recommended by the health care systems of multiple countries (including the U.S.) [</span><a href="https://caddra.ca/pdfs/caddraGuidelines2011.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.cdc.gov/ncbddd/adhd/school-success.html"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nice.org.uk/guidance/ng87/evidence/full-guideline-pdf-4783651311"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">There is strong evidence that shows patients with ADHD benefit from regular physical exercise.</span></p> <h4 style="text-align: justify;"><strong>Yoga and Mindfulness</strong></h4> <p style="text-align: justify;"><strong><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">Yoga</span></a><span style="font-weight: 400;"> and mindfulness-based therapies may relieve stress and support mental health by increasing serotonin levels. Studies suggest their potential to reduce ADHD symptoms in children and adults [</span><a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0063263/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/789821/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769029/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768216/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28038496"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045650/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25300813"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29356899"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></strong></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Bacopa</strong></h4> <p><strong><a href="https://selfhacked.com/blog/bacopa-monnieri-4/"><span style="font-weight: 400;">Bacopa</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Bacopa monnieri</span></em><span style="font-weight: 400;">) may enhance cognitive function and attention, in part by increasing serotonin levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24252493"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></strong></p> <p><strong><span style="font-weight: 400;"> In one review, bacopa extract (300 mg/day) improved language skills, hyperactivity, and attention deficit in children and adolescents [<a href="https://www.ncbi.nlm.nih.gov/pubmed/27912958">R</a>].</span></strong></p> <h4 style="text-align: justify;"><strong>Fish Oil (Omega-3 Fatty Acids)</strong></h4> <p><span style="font-weight: 400;">Omega-3 levels are lower in children with ADHD and taking supplements seems to show a modest improvement [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25181335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26985432/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK194890/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">These supplements generally contain many kinds of fatty acids: EPA helps by causing your nerve cells to release more serotonin whereas DHA makes the receptor that serotonin has to grab on to more accessible so that it can start doing its job [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25713056/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Consider supplementing with Omega-3 fatty acids -- they may provide a small benefit.</span></p>
319 | content_snp_table_6000482455087799_key == 6000482455087799
319 | content_snp_table_6000482455087799_blur == True
319 | content_snp_table_6000482455087799_hidden == False
319 | content_learn_more_5635189884287555_key == 5635189884287555
319 | content_learn_more_5635189884287555_blur == True
319 | content_learn_more_5635189884287555_hidden == False
319 | content_learn_more_5635189884287555_text == Based on the variants we looked at, your TPH2 gene makes you somewhat more likely to develop ADHD. However, this doesn't necessarily reflect your overall risk of ADHD; it’s just one gene related to it. Exercise, dietary modifications, and omega-3 supplements may help. Keep scrolling to find out more.
319 | content_recommendation_7742022664185424_key == 7742022664185424
319 | content_recommendation_7742022664185424_blur == True
319 | content_recommendation_7742022664185424_hidden == False
rsIDs = rs1843809,rs11179027,rs1386497,rs4570625
rsStatus = rs1843809,TPH2,chr12,71954918,G,A,T,,25,0,Normal
rsStatus = rs11179027,TPH2,chr12,71983532,G,C,,,31,0,Normal
rsStatus = rs1386497,TPH2,chr12,71998510,C,A,G,T,7,16,HET
rsStatus = rs4570625,TPH2,chr12,71938143,G,A,T,,30,0,Normal
