32 | id == 32
32 | category_id == 9
32 | category_order == 6
32 | category_name == Longevity
32 | category_color == #C47AC0
32 | slug == longevity-FOXO3
32 | title == Are You Genetically Predisposed to Live a Longer Life? (FOXO3)
32 | meta_description == One variant in FOXO3 can affect your lifespan as much as smoking a pack a day for 25 years. Learn how to hack this gene here.
32 | summary == <p><strong>One of the best-studied longevity genes, one variant in FOXO3 can affect your lifespan as much as smoking a pack a day for 25 years. Are you at risk? What can you do to live a longer life? Read on to find out.</strong></p>
32 | overall_score_text == Longevity Score (Based on FOXO3 Gene)
32 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Are-You-Genetically-Predisposed-to-Live-a-Longer-Life-FOXO3_JPG.jpg
32 | author_id == 1
32 | author_name == Jasmine Foster
32 | author_title == BSc, BEd
32 | author_order == 36
32 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
32 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
32 | reviewer_id == 2
32 | reviewer_name == Joe Cohen
32 | reviewer_title == BS
32 | medical_reviewer_id == 11
32 | medical_reviewer_name == Puya Yazdi
32 | medical_reviewer_title == MD
32 | publish_date == 2019
32 | publish_date == 8
32 | publish_date == 30
32 | avg_rating == 4.8
32 | tags_id == 105
32 | tags_name == Autophagy
32 | tags_id == 103
32 | tags_name == Forkhead Box
32 | tags_id == 102
32 | tags_name == FOXO3 Gene
32 | tags_id == 101
32 | tags_name == Longevity
32 | tags_id == 39
32 | tags_name == Oxidative Stress
32 | tags_id == 104
32 | tags_name == Tregs
32 | permissions_favorite == False
32 | permissions_rate == False
32 | content_article == <h2><span style="font-weight: 400;">Who Wants to Live Forever?</span></h2> <p><span style="font-weight: 400;">Human beings have been looking for ways to increase our lifespan since at least the beginning of recorded history. Before the advent of modern science, people told each other stories of a Fountain of Youth; more recently, stem cells and cryogenic freezing have inspired dreams of immortality [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299249/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133289/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The average life expectancy on Earth has been rising for generations due to improvements in medical knowledge and procedures, but some of the reasons we do or don&rsquo;t live for a long time are purely genetic. Your DNA is estimated to make up about 25% of the factors that influence your lifespan, where the other 75% comes from your environment and experiences [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632858/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ghr.nlm.nih.gov/primer/traits/longevity"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">*5237585252290744*</span></p> <h2><span style="font-weight: 400;">The Forkhead of Youth</span></h2> <p><span style="font-weight: 400;">One of the best-studied longevity genes is FOXO3, which codes for forkhead box protein O3. It is a member of the forkhead box (FOX) family of genes, which all encode transcription factors: proteins which regulate the expression of other genes. The FOXO subclass, of which FOXO3 is a member, regulates </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;"> signalling and protein metabolism in muscles [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124385/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the last decade or so, a large body of research has linked certain variants in the FOXO3 gene with longer lifespan [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595686/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807980/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009585/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544566/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.liebertpub.com/doi/abs/10.1089/rej.2008.0827"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXO3 is involved in tumor suppression, immune function, DNA repair, and resistance to oxidative stress [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572328/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819984/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">As Impactful as Smoking Cigarettes?</span></h3> <p><span style="font-weight: 400;">Some variations in the FOXO3 gene are enormously beneficial, while others are risky. At rs2802292, which has the greatest effect of any single SNP yet studied in FOXO3, the TT genotype confers the same risk as smoking a pack a day for 25 years, having 20 mmHg higher systolic blood pressure, or having 20 mg dL</span><span style="font-weight: 400;">-1</span><span style="font-weight: 400;"> higher </span><a href="https://selfhacked.com/blog/fasting-blood-glucose-test/"><span style="font-weight: 400;">fasting blood sugar</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933667/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another SNP, rs2802288, boasts a similar impact on longevity. This isn&rsquo;t surprising, given that the two variations are physically very close to each other in the DNA sequence; they are inherited together almost 100% of the time [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650329/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">FOXO3 regulates insulin signalling and protein metabolism in muscles. Surprisingly, some variants in FOXO3 have as much of an effect on longevity as smoking a pack of cigarettes per day for 25 years.</span></p> <h2><span style="font-weight: 400;">How Does FOXO3 Increase Your Lifespan?</span></h2> <p><span style="font-weight: 400;">In worm and fly models, increased FOXO3 expression increased lifespan. FOXO3 appears to promote tissue regeneration, autophagy (the cellular recycling system), and the growth of stem cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572328/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In rodents, FOXO3 also appears to increase the production of regulatory T cells (</span><a href="http://selfhacked.com/blog/treg/"><span style="font-weight: 400;">Tregs</span></a><span style="font-weight: 400;">), which regulate the immune response, promote tolerance of harmless proteins, and prevent autoimmunity. Mice without a functional FOXO3 gene were also many times more likely to develop cancer and die young [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXO3 also plays a role in managing oxidative stress. Mice without FOXO3 are highly susceptible to </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">reactive oxygen species</span></a><span style="font-weight: 400;"> in their bones, resulting in decreased bone mass and increased risk of fracture (osteoporosis). The antioxidant effect of FOXO3 has not yet been investigated in aged mice [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819984/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">In animals, FOXO3 promotes tissue regeneration, autophagy, and the growth of stem cells. Mice and rats without a functional FOXO3 gene tend to develop osteoporosis and die young of cancer.</span></p> <h2><span style="font-weight: 400;">Your FOXO3 Results for Longevity</span></h2> <p>*5237585252290744*</p> <h3><span style="font-weight: 400;">Frequency Data</span></h3> <p><span style="font-weight: 400;">How common or rare are the beneficial alleles? Where on Earth are they most common?</span></p> <p><strong>FOXO3 rs2802288</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Longer than average lifespan, more likely to live past 100</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Less likely to live past 100</span></li> </ul> <p><strong>FOXO3 rs12212067</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Longer than average lifespan, more likely to live past 100</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Less likely to live past 100</span></li> </ul> <p><strong>FOXO3 rs9398171</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Longer than average lifespan, more likely to live past 100</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Less likely to live past 100</span></li> </ul> <p><strong>FOXO3 rs9400239</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Longer than average lifespan, more likely to live past 100</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Less likely to live past 100</span></li> </ul> <p><strong>FOXO3 rs2802292</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Longer than average lifespan, more likely to live past 100</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Less likely to live past 100</span></li> </ul> <p><strong>FOXO3 rs4946936</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Longer than average lifespan, more likely to live past 100</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Less likely to live past 100</span></li> </ul> <p>*5994349586772187*</p> <h2><span style="font-weight: 400;">Recommendations to Extend Your Lifespan</span></h2> <p><span style="font-weight: 400;">The field of longevity research is complex and sometimes controversial. Before making significant changes to your diet, exercise regime, or supplements, talk to your doctor and make sure they're right for you.</span></p> <p><span style="font-weight: 400;">*3606654865352936*</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">Exercise induces FOXO3 and its closely related cousin </span><a href="../../gene/foxo1/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">FOXO1</span></a><span style="font-weight: 400;">, another transcription factor important for insulin signalling and reducing fat storage. This helps explain why people who are physically active tend to live longer! To increase FOXO3, commit to a fitness plan and </span><a href="http://selfhacked.com/blog/improve-focus-attention/"><span style="font-weight: 400;">focus</span></a><span style="font-weight: 400;"> on some forms of endurance training [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303382/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In mice, heat stress increased FOXO3 expression. This result suggests that using a sauna could help induce FOXO3 and extend lifespan. Indeed, some evidence has shown that people who regularly take sauna baths live longer lives [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27306326"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409598/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, intermittent fasting and calorie restriction activate FOXO3 [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036773/">R</a>].</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">Many polyphenols commonly found in plants we eat (especially fruits and vegetables) are capable of inducing FOXO3.&nbsp;</span></p> <p><span style="font-weight: 400;">While we don't usually get a large concentration of any single polyphenol in the diet, we do get many of them in smaller concentrations, and they have synergistic effects.</span></p> <p><span style="font-weight: 400;">A promising polyphenol to induce FOXO3 is EGCG, which is found primarily in </span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;"> at reasonable concentrations [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/theaflavins/"><span style="font-weight: 400;">Theaflavins</span></a><span style="font-weight: 400;">, a class of polyphenols found in black tea, stimulated FOXO3 activity in multiple cell studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30569095"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.sciencedirect.com/science/article/abs/pii/S1756464615002716"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In worms, epicatechins (which are found in the highest concentrations in cocoa) induce FOXO and improves the animals&rsquo; resistance to stress. In human athletes, drinking chocolate milk after exercise increases FOXO3 expression [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21904247"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199483"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The longest living person ever, Jeanne Calment, lived to 122.5 years old! She used to enjoy cocoa daily, sometimes indulging in a kilogram (2.2 lb) per week. She was able to do this despite smoking, probably because the cocoa increased her FOXO3 [</span><a href="https://en.wikipedia.org/wiki/Jeanne_Calment"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p><span style="font-weight: 400;">So, good news: eating a moderate amount of chocolate could increase your lifespan.</span></p> <p><span style="font-weight: 400;">Other polyphenols that have induced FOXO3 in a lab include [</span><a href="https://www.hindawi.com/journals/omcl/2017/4397340/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12010007"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/">Resveratrol</a><span style="font-weight: 400;"> found in grapes, wine, peanuts, Japanese Knotweed</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;">, abundant in </span><a href="https://www.selfhacked.com/blog/capers/"><span style="font-weight: 400;">capers</span></a><span style="font-weight: 400;">, apples, berries, broccoli, onions, and many other sources [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/top-11-science-based-health-benefits-luteolin/"><span style="font-weight: 400;">Luteolin</span></a><span style="font-weight: 400;">, abundant in carrots, cabbage, artichokes, tea, celery, and apples [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635727/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/top-11-science-based-health-benefits-apigenin/"><span style="font-weight: 400;">Apigenin</span></a><span style="font-weight: 400;">, abundant in celery, onions, oranges, and many herbs [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472148/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">A diet rich in polyphenols may help induce FOXO3 and extend your lifespan. Many fruits and vegetables contain helpful polyphenols like quercetin, luteolin, and apigenin; they are particularly abundant in apples, onions, and many herbs.</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Some polyphenols can be taken as supplements; if you have lots of risk alleles in the table above, you may want to consider taking one or more of these compounds, each of which have been found to induce FOXO3:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> (bioavailable) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/">Resveratrol</a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12010007"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;"><a href="https://selfhacked.com/blog/chinese-skullcap/">Chinese skullcap</a> (<a href="https://selfhacked.com/blog/baicalein-baicalin-top-7-health-benefits-flavanoid/">baicalein</a>) [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457308/">R</a>]</span></li> </ul> <p><span style="font-weight: 400;">Curcumin and EGCG were able to extend lifespan in flies and worms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20645870"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635249/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26375250"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One review study found that resveratrol supplements extended the lives of about 60% of animal models; however, results varied widely from one species to another. Researchers don&rsquo;t currently agree on whether resveratrol significantly affects human lifespan [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27781945"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Drugs</span></h3> <p><a href="https://selfhacked.com/blog/uses-benefits-metformin/"><span style="font-weight: 400;">Metformin</span></a><span style="font-weight: 400;">, a prescription antidiabetic drug, has been observed to directly increase FOXO3 expression. In fact, metformin reduces risk of death from all causes even in people without diabetes; some people take metformin specifically as an anti-aging drug [</span><a href="http://www.bloodjournal.org/content/126/23/282?sso-checked=true"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28802803"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you are taking metformin for any reason, they may help counteract FOXO3 risk alleles. Always talk to your doctor before adding or changing medications.</span></p>
32 | content_snp_table_5994349586772187_key == 5994349586772187
32 | content_snp_table_5994349586772187_blur == True
32 | content_snp_table_5994349586772187_hidden == False
32 | content_learn_more_5237585252290744_key == 5237585252290744
32 | content_learn_more_5237585252290744_blur == True
32 | content_learn_more_5237585252290744_hidden == False
32 | content_learn_more_5237585252290744_text == Based on the variants we looked at, your FOXO3 gene makes you likely to live a somewhat longer lifespan. You can extend it even further by exercising, eating nutritious vegetables, and maybe taking a few polyphenol supplements. Keep scrolling to find out more.
32 | content_recommendation_3606654865352936_key == 3606654865352936
32 | content_recommendation_3606654865352936_blur == True
32 | content_recommendation_3606654865352936_hidden == False
rsIDs = rs9400239,rs9398171,rs12212067,rs4946936,rs2802288,rs2802292
rsStatus = rs9400239,FOXO3,chr6,108656460,T,C,G,,3,37,HET
rsStatus = rs9398171,FOXO3,chr6,108662324,C,A,G,T,24,0,Normal
rsStatus = rs12212067,FOXO3,chr6,108659993,T,G,,,27,0,Normal
rsStatus = rs4946936,FOXO3,chr6,108682118,T,A,C,G,44,0,Normal
rsStatus = rs2802288,FOXO3,chr6,108575012,A,G,T,,10,22,HET
rsStatus = rs2802292,FOXO3,chr6,108587315,G,T,,,2,43,HET
