322 | id == 322
322 | category_id == 20
322 | category_order == 17
322 | category_name == Attention
322 | category_color == #C47AC0
322 | slug == NRG1-executive-function
322 | title == How Does Brain Development Impact Attention and Memory? (NRG1)
322 | meta_description == NRG1 is important in brain development. Variants of NRG1 have been associated with cognitive impairments. Read more here.
322 | summary == <p style="text-align:justify"><strong>The <em>NRG1</em> gene plays an important role in establishing inhibitory brain cell connections during brain development. Variants of <em>NRG1</em> have been associated with cognitive impairments, such as attentional control and working memory deficits. Scroll down to learn more.</strong></p>
322 | overall_score_text == Your Executive Function Score (based on NRG1 gene)
322 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NRG1-Attention.jpg
322 | author_id == 14
322 | author_name == Shany Lahan
322 | author_title == MS (Neuroscience)
322 | author_order == 5
322 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
322 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
322 | reviewer == None
322 | medical_reviewer_id == 11
322 | medical_reviewer_name == Puya Yazdi
322 | medical_reviewer_title == MD
322 | publish_date == 2020
322 | publish_date == 9
322 | publish_date == 10
322 | avg_rating == 5.0
322 | tags_id == 30
322 | tags_name == ADHD
322 | tags_id == 56
322 | tags_name == Attention
322 | tags_id == 54
322 | tags_name == Executive Function
322 | tags_id == 699
322 | tags_name == NRG1 Gene
322 | tags_id == 109
322 | tags_name == Working Memory
322 | permissions_favorite == False
322 | permissions_rate == False
322 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">NRG1 </span></em><span style="font-weight: 400;">gene codes for neuregulin 1, a protein important in establishing inhibitory brain cell connections during brain development.&nbsp;</span></span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">NRG1 </span></em><span style="font-weight: 400;">may alter brain development, leading to attentional control and working memory deficits.</span></span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Lifestyle, diet, and supplement modifications may improve attentional control and working memory deficits by strengthening, weakening, and reorganizing brain cell connections.</span></li> </ul> <h2 style="text-align: justify;"><strong><em>NRG1</em> and Executive Function</strong></h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="../../../gene/nrg1/"><em><span style="font-weight: 400;">NRG1 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for a protein called neuregulin 1.&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Neuregulin 1 is involved in establishing inhibitory brain cell (neuron) connections during normal brain development. Their establishment is part of </span><a href="https://selfhacked.com/blog/synaptic-plasticity/"><span style="font-weight: 400;">neuroplasticity</span></a><span style="font-weight: 400;">: a process that can strengthen, weaken, and reorganize connections between neurons [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297728/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28817803/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290679/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Inhibitory neuronal connections are important for higher-order (executive) brain functions, including attentional control and </span><a href="https://selfhacked.com/blog/different-types-memory/"><span style="font-weight: 400;">working memory</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297728/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In developmental disorders such as ADHD, deficits in attentional control and working memory are common [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297728/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30415889/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Variants of the </span><em><span style="font-weight: 400;">NRG1 </span></em><span style="font-weight: 400;">gene may result in reduced neuroplasticity during periods of brain development, leading to attentional control and working memory deficits [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297728/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14569272/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30415889/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2 style="text-align: justify;"><strong>Your <em>NRG1</em> Results for Attentional Control and Working Memory</strong></h2> <p>*3595629329604848*</p> <p style="text-align: justify;"><strong>Primary SNP: </strong><strong><em>NRG1 </em></strong><a href="../../../snp/rs6994992/"><strong>rs6994992</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of working memory deficit</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of working memory deficit</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs: </strong><strong><em>NRG1 </em></strong><a href="../../../snp/rs35753505/"><strong>rs35753505</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CT&rsquo; = Decreased risk of attentional control deficit</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;TT&rsquo; = Normal risk of attentional control deficit&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CC&rsquo; = Increased risk of attentional control deficit</span></li> </ul> <p style="text-align: justify;">*1717866940083818*</p> <h2><strong>Recommendations for Improving Attentional Control and Working Memory</strong></h2> <p style="text-align: justify;">*2954994256702481*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Exercise&nbsp;</strong></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">There is abundant evidence showing that </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">physical exercise</span></a><span style="font-weight: 400;"> can promote neuroplasticity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17879376/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16298350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20869354/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29959048/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Many studies have also demonstrated that physical exercise may have significant benefits on cognitive and behavioral symptoms associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28917364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">A randomized controlled trial found that long-term physical exercise can specifically improve working memory in individuals with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25561359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In children and adolescents with ADHD, attention significantly improved after taking part in different exercise programs [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724411/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21432590"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Physical exercise may improve attention and working memory by promoting neuroplasticity.</span></p> <h4 style="text-align: justify;"><strong>Sufficient Sleep</strong></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Many </span><a href="https://selfhacked.com/blog/sleep-neurophysiology/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> deprivation studies have suggested that sleep can promote neuroplasticity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20050994/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16376302/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17135407/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Loss of sleep duration and quality can impair a variety of cognitive functions, including attention and working memory [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15509816/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12405615/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In an observational study of children with ADHD, sufficient sleep was associated with increased executive functioning [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23934136/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Sufficient sleep may improve attention and working memory by promoting neuroplasticity.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Fish Oil (Omega-3)</strong></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Fish oil</span></a><span style="font-weight: 400;"> contains DHA and EPA, two types of omega-3 fatty acids [</span><a href="https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Many studies have shown that fish oil can promote neuroplasticity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16500747/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30367533/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23872044/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fish oil was associated with reductions in ADHD-related symptoms in a number of clinical trials [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/11817499"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/18469236"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/17435458"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21807480/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24958525/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Specifically, children with ADHD experienced significant improvements in attention and working memory after fish oil supplementation [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/18469236"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/17435458"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24958525/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil (omega-3) may improve attention and working memory by promoting neuroplasticity.</span></p>
322 | content_snp_table_3595629329604848_key == 3595629329604848
322 | content_snp_table_3595629329604848_blur == True
322 | content_snp_table_3595629329604848_hidden == False
322 | content_learn_more_1717866940083818_key == 1717866940083818
322 | content_learn_more_1717866940083818_blur == True
322 | content_learn_more_1717866940083818_hidden == False
322 | content_learn_more_1717866940083818_text == Based on the variants we looked at, your NRG1 gene is somewhat associated with working memory and attentional control deficits. However, this doesn't necessarily reflect your overall risk of working memory and attentional control deficits; it’s just one gene related to it. Exercise, sufficient sleep, and fish oil (omega-3) supplements may help. Keep scrolling to find out more.
322 | content_recommendation_2954994256702481_key == 2954994256702481
322 | content_recommendation_2954994256702481_blur == True
322 | content_recommendation_2954994256702481_hidden == False
rsIDs = rs6994992,rs35753505
rsStatus = rs6994992,NRG1,chr8,31638065,C,A,T,,42,0,Normal
rsStatus = rs35753505,,chr8,31616625,T,A,C,G,26,0,Normal
