325 | id == 325
325 | category_id == 20
325 | category_order == 17
325 | category_name == Attention
325 | category_color == #C47AC0
325 | slug == HTR2C-serotonin-ADHD
325 | title == Serotonin Genetics in ADHD (HTR2C)
325 | meta_description == The HTR2C gene plays crucial roles in mental health and cognition. Learn about its link with ADHD.
325 | summary == <p style="text-align:justify"><strong>Scientists have discovered another genetic factor that connects serotonin and attention disorders. Read this post to learn the link between the HTR2C gene and ADHD.</strong></p>
325 | overall_score_text == Your ADHD Score (Based on HTR2C Gene)
325 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HTR2C-ADHD.jpg
325 | author_id == 9
325 | author_name == Aleksa Ristic
325 | author_title == MS (Pharmacy)
325 | author_order == 45
325 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
325 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
325 | reviewer == None
325 | medical_reviewer_id == 11
325 | medical_reviewer_name == Puya Yazdi
325 | medical_reviewer_title == MD
325 | publish_date == 2020
325 | publish_date == 9
325 | publish_date == 12
325 | avg_rating == 5.0
325 | tags_id == 701
325 | tags_name == 5-HT2C receptor
325 | tags_id == 30
325 | tags_name == ADHD
325 | tags_id == 56
325 | tags_name == Attention
325 | tags_id == 13
325 | tags_name == Cognition
325 | tags_id == 478
325 | tags_name == HTR2C Gene
325 | tags_id == 309
325 | tags_name == Serotonin
325 | permissions_favorite == False
325 | permissions_rate == False
325 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The HTR2C gene encodes a serotonin receptor, 5-HT2C, with crucial roles in cognition and mental health.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific gene variants may reduce 5-HT2C receptor activity and contribute to ADHD development.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Our gene-based recommendations enhance cognition and improve ADHD symptoms by targeting these variants.</strong></span></p> <h2><strong>The Role of HTR2C Gene in ADHD</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/htr2c/"><em><span style="font-weight: 400;">HTR2C</span></em></a><span style="font-weight: 400;"> gene encodes a serotonin receptor, </span><a href="http://selfhacked.com/blog/5-ht2c/"><span style="font-weight: 400;">5-HT2C</span></a><span style="font-weight: 400;">, present mostly in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3358"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Reduced 5-HT2C activity has potential benefits for mental health, but it also contributes to impulsivity and cognitive impairment &mdash; key ADHD features&nbsp; [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30074224/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873585/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957106/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">ADHD is associated with impaired serotonin functions in the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/1143984/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20921119/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your HTR2C Results for ADHD</strong></h2> <p>*Note that HTR2C is on the X chromosome, so men (XY) will have single-lettered genotypes.</p> <h3>*6066450042980516*</h3> <p><strong>Primary SNPs:</strong></p> <p><strong><em>HTR2C</em></strong> <a href="https://selfdecode.com/snp/rs518147/"><strong>rs518147</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30074224/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may reduce 5-HT2C receptor activity and deplete serotonin&nbsp;</span></li> </ul> <p><strong><em>HTR2C</em></strong> <a href="https://selfdecode.com/snp/rs3813929/"><strong>rs3813929</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/30074224/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may reduce 5-HT2C receptor activity and deplete serotonin</span></li> </ul> <p>*8381522170651605*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Enhance Attention</strong></h2> <p>*3798418353082366*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Massage</strong></h4> <p><span style="font-weight: 400;">According to limited clinical evidence, <a href="https://selfhacked.com/blog/massage-health-benefits/" target="_blank" rel="noopener">massage</a> may enhance focus, behavior, and mood control in children and adolescents with ADHD [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9583664/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15053490/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Massage may counteract your variants by boosting serotonin levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16162447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Sleep</strong></h4> <p><span style="font-weight: 400;">Poor </span><a href="https://selfhacked.com/blog/sleep-neurophysiology/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> quality impairs attention and other cognitive functions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12683469"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15509816/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/3238256/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9682180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Chronic sleep deprivation may deplete serotonin and reduce receptor sensitivity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different sleep interventions improved cognitive performance and overall well-being in children with ADHD [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30654852"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24957753"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31184382"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22005602"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Improved sleep quality may help lessen the impact of your gene variant on attention.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Ginseng</strong></h4> <p><span style="font-weight: 400;">Folks have used Korean </span><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginseng</span></a><span style="font-weight: 400;"> as a cognitive stimulant for ages [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14596440/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026386/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary research has shown its potential to reduce inattention and hyperactivity in ADHD patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659525/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006981/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25369174/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Ginseng can bind and activate the 5-HT2C receptor [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20804838/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Ginseng can enhance cognition and improve ADHD symptoms by targeting your gene variants.</span></p>
325 | content_snp_table_6066450042980516_key == 6066450042980516
325 | content_snp_table_6066450042980516_blur == True
325 | content_snp_table_6066450042980516_hidden == False
325 | content_learn_more_8381522170651605_key == 8381522170651605
325 | content_learn_more_8381522170651605_blur == True
325 | content_learn_more_8381522170651605_hidden == False
325 | content_learn_more_8381522170651605_text == Based on the variants we looked at, your HTR2C gene is associated with slightly higher odds of ADHD. However, this doesn't necessarily reflect your overall risk of ADHD, just one gene related to it. Massage and ginseng supplementation may improve ADHD symptoms by targeting your gene variants. Keep reading to learn more.
325 | content_recommendation_3798418353082366_key == 3798418353082366
325 | content_recommendation_3798418353082366_blur == True
325 | content_recommendation_3798418353082366_hidden == False
rsIDs = rs518147,rs3813929
rsStatus = rs518147,HTR2C,chrX,114584109,C,A,G,,19,0,Normal
rsStatus = rs3813929,HTR2C,chrX,114584047,C,G,T,,17,0,Normal
