328 | id == 328
328 | category_id == 20
328 | category_order == 17
328 | category_name == Attention
328 | category_color == #C47AC0
328 | slug == SLC6A2-Attention
328 | title == How Does This Gene Relate To ADHD? (SLC6A2)
328 | meta_description == SLC6A2 gene variants may be affecting your ADHD susceptibility. Read on to find out more!
328 | summary == <p style="text-align:justify"><strong><em>SLC6A2</em> variants may influence your ADHD susceptibility. Read on to find out the impact these variants may be having on you and what you can do to reduce it!</strong></p>
328 | overall_score_text == Your ADHD Score (based on SLC6A2 gene)
328 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SLC6A2-NET1-ADHD.jpg
328 | author_id == 13
328 | author_name == Lewis Cuthbertson
328 | author_title == PhD
328 | author_order == 12
328 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
328 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
328 | reviewer == None
328 | medical_reviewer_id == 11
328 | medical_reviewer_name == Puya Yazdi
328 | medical_reviewer_title == MD
328 | publish_date == 2020
328 | publish_date == 9
328 | publish_date == 15
328 | avg_rating == 5.0
328 | tags_id == 30
328 | tags_name == ADHD
328 | tags_id == 56
328 | tags_name == Attention
328 | tags_id == 52
328 | tags_name == Norepinephrine
328 | tags_id == 557
328 | tags_name == Omega-3 Fatty Acids
328 | tags_id == 705
328 | tags_name == SLC6A2 gene
328 | permissions_favorite == False
328 | permissions_rate == False
328 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <p><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <a href="https://selfdecode.com/gene/slc6a2/"><em>SLC6A2</em></a> gene encodes <a href="https://selfhacked.com/blog/norepinephrine-stress-hormone/">norepinephrine</a> transporter proteins.<br /><br />Norepinephrine is a neurotransmitter, and an imbalance of it is linked to ADHD.<br /><br /><em>SLC6A2 </em>variants may cause norepinephrine imbalance.</span></strong></p> <h2><em><span style="font-weight: 400;">SLC6A2</span></em><span style="font-weight: 400;"> and ADHD</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">SLC6A2 </span></em><span style="font-weight: 400;">(Solute carrier family 6 member 2) gene encodes norepinephrine transporter proteins.</span></p> <p><span style="font-weight: 400;">These proteins transport the neurotransmitter norepinephrine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1127537/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Norepinephrine is responsible for several aspects of attention including increased focus, memory recall and alertness [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811862/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Dysfunction of the norepinephrine system has been linked to ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26528750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Drugs that lower </span><em><span style="font-weight: 400;">SLC6A2</span></em><span style="font-weight: 400;"> activity have been shown to improve ADHD symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450174/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The effects of the </span><em><span style="font-weight: 400;">SLC6A2</span></em><span style="font-weight: 400;"> gene are stronger in males [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18937309/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Gene variants of the </span><em><span style="font-weight: 400;">SLC6A2 </span></em><span style="font-weight: 400;">gene may reduce norepinephrine levels in the brain, contributing to ADHD.</span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">SLC6A2</span></em><span style="font-weight: 400;"> Results for ADHD</span></h2> <h3>*1458424314088267*</h3> <h3><span style="font-weight: 400;">SNP Table and Summary</span></h3> <p><strong><em>SLC6A2</em></strong><strong>&nbsp;rs3785143</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17876324/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with ADHD</span></li> </ul> <p><strong><em>SLC6A2</em> rs3785157</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with ADHD (inattention) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27230021/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with ADHD</span></li> </ul> <p><strong><em>SLC6A2</em> rs2242447</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23872233/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with ADHD</span></li> </ul> <p><strong><em>SLC6A2</em> rs11568324</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17876324/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with ADHD</span></li> </ul> <p><strong>*5983706977507743*</strong></p> <h2><span style="font-weight: 400;">Recommendations for Improving Attention</span></h2> <p><strong>*5809543173889185*</strong></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> promotes healthy norepinephrine levels in the brain when taken for a sustained period of time. Exercise has also been shown to improve ADHD symptoms in children and adults [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8226467/"><span style="font-weight: 400;">R</span></a><strong>, </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27400928/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Nerve Stimulation</strong></h4> <p><span style="font-weight: 400;">Different nerve stimulation techniques improved ADHD symptoms in preliminary research. The FDA has approved a transcranial nerve stimulation (TNS) device for ADHD treatment in children [<a href="https://pubmed.ncbi.nlm.nih.gov/15537992/">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/25533244/">R</a>, <a href="https://www.fda.gov/news-events/press-announcements/fda-permits-marketing-first-medical-device-treatment-adhd#:~:text=The%20prescription%2Donly%20device%2C%20called,marketing%20authorization%20by%20the%20FDA.">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/16962076/">R</a>].</span></p> <p><span style="font-weight: 400;">Nerve stimulation works by balancing norepinephrine and other neurotransmitters in the brain [<a href="https://pubmed.ncbi.nlm.nih.gov/16962076/">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485914/">R</a>].</span></p> <h3><strong>Supplements</strong></h3> <p><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3</span></a><span style="font-weight: 400;"> supplementation may reduce the amount of norepinephrine that is transported out of the brain. In clinical trials, omega-3s showed positive effects on ADHD symptoms such as inattention [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15452023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25790022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. </span></p>
328 | content_snp_table_1458424314088267_key == 1458424314088267
328 | content_snp_table_1458424314088267_blur == True
328 | content_snp_table_1458424314088267_hidden == False
328 | content_learn_more_5983706977507743_key == 5983706977507743
328 | content_learn_more_5983706977507743_blur == True
328 | content_learn_more_5983706977507743_hidden == False
328 | content_learn_more_5983706977507743_text == Based on the variants we looked at, your SLC6A2 gene makes you somewhat more likely to develop ADHD. However, this doesn't necessarily reflect your overall risk; it’s just one gene related to it. Keep scrolling to find out more.
328 | content_recommendation_5809543173889185_key == 5809543173889185
328 | content_recommendation_5809543173889185_blur == True
328 | content_recommendation_5809543173889185_hidden == False
rsIDs = rs2242447,rs3785157,rs3785143,rs11568324
rsStatus = rs2242447,SLC6A2,chr16,55702000,C,A,G,T,35,0,Normal
rsStatus = rs3785157,SLC6A2,chr16,55695924,C,T,,,18,14,HET
rsStatus = rs3785143,SLC6A2,chr16,55661194,C,T,,,28,0,Normal
rsStatus = rs11568324,SLC6A2,chr16,55692146,C,T,,,32,0,Normal
