329 | id == 329
329 | category_id == 20
329 | category_order == 17
329 | category_name == Attention
329 | category_color == #C47AC0
329 | slug == DBH-ADHD
329 | title == Can This Gene Increase Your Risk Of ADHD? (DBH)
329 | meta_description == DBH gene variants may be affecting your ADHD susceptibility. Read on to find out more!
329 | summary == <p style="text-align:justify"><strong><em>DBH</em> variants may influence your ADHD susceptibility. Read on to find out the impact these variants may be having on you and what you can do to reduce it!</strong></p>
329 | overall_score_text == Your ADHD Score (based on DBH gene)
329 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/DBH-ADHD.jpg
329 | author_id == 13
329 | author_name == Lewis Cuthbertson
329 | author_title == PhD
329 | author_order == 12
329 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
329 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
329 | reviewer == None
329 | medical_reviewer_id == 11
329 | medical_reviewer_name == Puya Yazdi
329 | medical_reviewer_title == MD
329 | publish_date == 2020
329 | publish_date == 9
329 | publish_date == 15
329 | avg_rating == 5.0
329 | tags_id == 30
329 | tags_name == ADHD
329 | tags_id == 56
329 | tags_name == Attention
329 | tags_id == 636
329 | tags_name == DBH Gene
329 | tags_id == 51
329 | tags_name == Dopamine
329 | tags_id == 207
329 | tags_name == Exercise
329 | tags_id == 52
329 | tags_name == Norepinephrine
329 | tags_id == 557
329 | tags_name == Omega-3 Fatty Acids
329 | permissions_favorite == False
329 | permissions_rate == False
329 | content_article == <h2 style="text-align: justify;"><span style="font-weight: 400;">Summary</span></h2> <p><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <a href="https://selfdecode.com/gene/dbh/"><em>DBH</em></a> gene encodes an enzyme that converts <a href="https://selfhacked.com/blog/dopamine/">dopamine</a> to <a href="https://selfhacked.com/blog/norepinephrine-stress-hormone/">norepinephrine</a>.<br /><br />Imbalanced dopamine/norepinephrine may increase the risk of ADHD.<br /><br /><em>DBH</em> variants may cause lower enzyme levels, reducing norepinephrine and contributing towards ADHD risk.&nbsp;</span></strong></p> <h2 style="text-align: justify;"><em><span style="font-weight: 400;">DBH</span></em><span style="font-weight: 400;"> and ADHD</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">DBH</span></em><span style="font-weight: 400;"> gene encodes dopamine beta-hydroxylase, an enzyme that converts dopamine to norepinephrine in the brain.</span></p> <p><span style="font-weight: 400;">DBH is therefore key in balancing dopamine and norepinephrine.&nbsp;</span></p> <p><span style="font-weight: 400;">Lower DBH may cause an imbalance between these two neurotransmitters, with less dopamine being converted to norepinephrine.</span></p> <p><span style="font-weight: 400;">This imbalance has been linked to ADHD [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846438/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15088079/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15950004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">DBH gene variants may decrease DBH levels increasing the risk of ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16616730/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.biologicalpsychiatryjournal.com/article/S0006-3223(06)00235-6/pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19757024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17457369/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">DBH</span></em><span style="font-weight: 400;"> Results for ADHD</span></h2> <h3 style="text-align: justify;">*3043008017570388*</h3> <h3 style="text-align: justify;"><span style="font-weight: 400;">SNP Table and Summary</span></h3> <p style="text-align: justify;"><strong><em>DBH</em></strong><strong> rs1611115:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with ADHD risk and decreased DBH levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18982239/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17625104/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with protection against ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23692268/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><strong><em>DBH</em></strong><strong> rs2519154:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18180757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15950004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with ADHD</span></li> </ul> <p style="text-align: justify;"><strong><em>DBH</em></strong><strong> rs7040170:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased DBH levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24986918/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = No decrease in DBH levels</span></li> </ul> <p style="text-align: justify;"><strong><em>DBH</em></strong><strong> rs1108580:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21216270/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with ADHD</span></li> </ul> <p style="text-align: justify;"><strong><em>DBH</em></strong><strong> rs2873804:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18180757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15950004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with ADHD</span></li> </ul> <p style="text-align: justify;"><strong><em>DBH</em></strong><strong> rs2519152:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with ADHD and decreased DBH levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16380908/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16616730/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964758/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with ADHD or altered DBH levels</span></li> </ul> <p style="text-align: justify;"><strong><em>DBH</em></strong><strong> rs1076150:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18180757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15950004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with ADHD</span></li> </ul> <p style="text-align: justify;"><strong>*1059557761696077*</strong></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Recommendations for Improving Attention</span></h2> <p style="text-align: justify;"><strong>*9405849425154431*</strong></p> <h3><strong>Exercise</strong></h3> <p><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> promotes healthy norepinephrine levels in the brain when taken for a sustained period of time. Exercise has also been shown to improve ADHD symptoms in children and adults [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8226467/"><span style="font-weight: 400;">R</span></a><strong>, </strong><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27400928/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Nerve Stimulation</strong></h3> <p><strong><span style="font-weight: 400;">Different nerve stimulation techniques improved ADHD symptoms in preliminary research. The FDA has approved a transcranial nerve stimulation (TNS) device for ADHD treatment in children [<a href="https://pubmed.ncbi.nlm.nih.gov/16962076/">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485914/">R</a>].</span></strong></p> <p><strong><span style="font-weight: 400;">Nerve stimulation works by balancing norepinephrine and other neurotransmitters in the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15537992/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25533244/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.fda.gov/news-events/press-announcements/fda-permits-marketing-first-medical-device-treatment-adhd#:~:text=The%20prescription%2Donly%20device%2C%20called,marketing%20authorization%20by%20the%20FDA."><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16962076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></strong></p> <h3 style="text-align: justify;"><strong>Fish/Omega-3</strong></h3> <p><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3</span></a><span style="font-weight: 400;"> fatty acids may increase norepinephrine levels in the brain. ADHD patients tend to have lower omega-3 intakes and blood levels. For this reason, some health experts suggest increasing fish and seafood intake as a complementary approach to attention disorders [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15452023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669464/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562756/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Supplementation with omega-3 fatty acids found in </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> improved ADHD symptoms in multiple clinical studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25790022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21807480/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24958525/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25181335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26985432/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK194890/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25713056/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
329 | content_snp_table_3043008017570388_key == 3043008017570388
329 | content_snp_table_3043008017570388_blur == True
329 | content_snp_table_3043008017570388_hidden == False
329 | content_learn_more_1059557761696077_key == 1059557761696077
329 | content_learn_more_1059557761696077_blur == True
329 | content_learn_more_1059557761696077_hidden == False
329 | content_learn_more_1059557761696077_text == Based on the variants we looked at, your DBH gene makes you somewhat more likely to develop ADHD. However, this doesn't necessarily reflect your overall risk; it’s just one gene related to it. Keep scrolling to find out more.
329 | content_recommendation_9405849425154431_key == 9405849425154431
329 | content_recommendation_9405849425154431_blur == True
329 | content_recommendation_9405849425154431_hidden == False
rsIDs = rs2519152,rs2519154,rs2873804,rs7040170,rs1076150,rs1108580,rs1611115
rsStatus = rs2519152,DBH,chr9,133644512,T,C,,,23,16,HET
rsStatus = rs2519154,DBH,chr9,133647153,T,A,C,G,24,0,Normal
rsStatus = rs2873804,DBH,chr9,133640522,T,A,C,,34,0,Normal
rsStatus = rs7040170,SARDH,chr9,133721245,A,G,,,18,15,HET
rsStatus = rs1076150,,chr9,133633639,T,C,,,20,12,HET
rsStatus = rs1108580,DBH,chr9,133639992,A,G,,,23,10,HET
rsStatus = rs1611115,DBH,chr9,133635393,T,A,C,G,30,0,Normal
