33 | id == 33
33 | category_id == 6
33 | category_order == 4
33 | category_name == Thyroid
33 | category_color == #C47AC0
33 | slug == low-thyroid-FOXE1
33 | title == Why Do Some People Have Better Thyroid Health? (FOXE1)
33 | meta_description == Specific FOXE1 variants correlate with much lower rates of hypothyroidism. Learn more about this "protective" gene here!
33 | summary == <p dir="ltr"><strong>Out of many genes that impact thyroid hormones, FOXE1 has shown the strongest association. Specific variations correlate with much lower rates of&nbsp;hypothyroidism, but they also have a downside. Read on to learn more about this connection and check your genes.</strong></p>
33 | overall_score_text == Hypothyroidism Score (Based on FOXE1 Gene)
33 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/How-To-Boost-Your-Thyroid-Hormones-by-Hacking-the-FOXE1-Gene_JPG.jpg
33 | author_id == 9
33 | author_name == Aleksa Ristic
33 | author_title == MS (Pharmacy)
33 | author_order == 45
33 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
33 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
33 | reviewer_id == 1
33 | reviewer_name == Jasmine Foster
33 | reviewer_title == BSc, BEd
33 | medical_reviewer_id == 11
33 | medical_reviewer_name == Puya Yazdi
33 | medical_reviewer_title == MD
33 | publish_date == 2019
33 | publish_date == 8
33 | publish_date == 30
33 | avg_rating == 4.4
33 | tags_id == 33
33 | tags_name == Autoimmunity
33 | tags_id == 106
33 | tags_name == FOXE1 Gene
33 | tags_id == 43
33 | tags_name == Hypothyroidism
33 | tags_id == 41
33 | tags_name == Thyroid
33 | tags_id == 107
33 | tags_name == TPO
33 | permissions_favorite == False
33 | permissions_rate == False
33 | content_article == <p><span style="font-weight: 400;">Thyroid disorders affect more than 20 million Americans. Genetic factors, including FOXE1 variations, account for 50-90% of thyroid hormone variations [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21893493"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24086088"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><span style="font-weight: 400;">The FOXE1 Gene</span></h2> <p><a href="../../gene/foxe1/"><span style="font-weight: 400;">FOXE1</span></a><span style="font-weight: 400;"> (Forkhead box E1) encodes a protein crucial for the proper maturation of the thyroid gland in early development [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086810/"><span style="font-weight: 400;">R</span><span style="font-weight: 400;">, </span></a><a href="https://www.ncbi.nlm.nih.gov/pubmed/15466939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9697704/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591984/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXE1 regulates Thyroid peroxidase (TPO) and </span><a href="https://selfhacked.com/blog/thyroglobulin/"><span style="font-weight: 400;">Thyroglobulin</span></a><span style="font-weight: 400;"> (Tg), which are used to make the thyroid hormones </span><a href="https://selfhacked.com/blog/thyroid-hormones-t4t3/"><span style="font-weight: 400;">(T4)</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24692351/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15466939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9697704/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In adults, FOXE1 </span><em><span style="font-weight: 400;">suppresses</span></em><span style="font-weight: 400;"> the activity of the TPO gene, which inhibits the production of thyroid hormones [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1169936/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10944465/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">FOXE1 helps the maturation of the thyroid gland in early development but can inhibit thyroid hormone production in adults.</span></p> <h2><span style="font-weight: 400;">FOXE1 Variants and Hypothyroidism</span></h2> <p><span style="font-weight: 400;">In a study with 6,300 participants, the less common (minor) alleles on four FOXE1 variants inversely correlated with </span><span style="font-weight: 400;"><a href="https://selfhacked.com/blog/hypothyroidism-may-good-autoimmunity/">hypothyroidism</a> [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188836/" target="_blank" rel="noopener">R</a>]: </span></p> <ul> <li><span style="font-weight: 400;"><a href="../../snp/rs7850258/">rs7850258</a>-A</span></li> <li><span style="font-weight: 400;"><a href="../../snp/rs925489/">rs925489</a>-C</span></li> <li><span style="font-weight: 400;"><a href="../../snp/rs965513/">rs965513</a>-A</span></li> <li><span style="font-weight: 400;"><a href="../../snp/rs10759944/">rs10759944</a>-A</span></li> </ul> <p><span style="font-weight: 400;">People with these alleles had 33-35% lower disease rates</span><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">Minor allele carriers also had lower rates of thyroid inflammation (thyroiditis) and goiter. On the other hand, these variants may correlate with thyroid cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Data from over 40,000 subjects confirmed FOXE1 as a key genetic factor for hypothyroidism. The authors emphasized an inverse association of the less common &ldquo;C&rdquo; allele at </span><a href="../../snp/rs925489/"><span style="font-weight: 400;">rs925489</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Certain FOXE1 variants correlate with lower rates of hypothyroidism and thyroid inflammation but higher rates of thyroid cancer.</span></p> <h3><span style="font-weight: 400;">How It Works</span></h3> <p><span style="font-weight: 400;">Scientists suggest that the above variants</span><span style="font-weight: 400;"> reduce FOXE1 expression and allow for improved thyroid hormone production (T4) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476440/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The effect allele carriers (</span><a href="../../snp/rs7850258/"><span style="font-weight: 400;">rs7850258</span></a><span style="font-weight: 400;">-A) also had lower rates of autoimmune thyroiditis or </span><a href="https://selfhacked.com/blog/hashimotos/"><span style="font-weight: 400;">Hashimoto&rsquo;s disease</span></a><span style="font-weight: 400;">, which suggests autoimmunity as another potential mechanism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, some of these variants are associated with thyroid cancer, indicating a tumor-suppressor role of the FOXE1 gene [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993030/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The above FOXE1 variants may stimulate thyroid hormone production. People with these variants also have lower rates of autoimmune hypothyroidism.</span></p> <h2><span style="font-weight: 400;">Your FOXE1 Results for Hypothyroidism</span></h2> <p><span style="font-weight: 400;">*5539810132638319*</span></p> <h3><span style="font-weight: 400;">SNP Summary</span></h3> <p><strong>Primary SNPs</strong><span style="font-weight: 400;">:&nbsp;</span></p> <p><a href="../../gene/foxe1/"><span style="font-weight: 400;">FOXE1</span></a> <a href="../../snp/rs925489/"><span style="font-weight: 400;">rs925489</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; allele doesn't correlate with hypothyroidism</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; allele correlates with lower rates of hypothyroidism</span></li> </ul> <p><a href="../../gene/foxe1/"><span style="font-weight: 400;">FOXE1</span></a> <a href="../../snp/rs7850258/"><span style="font-weight: 400;">rs7850258</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; allele doesn't correlate with hypothyroidism</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; allele correlates with lower rates of hypothyroidism</span></li> </ul> <p><a href="../../gene/foxe1/"><span style="font-weight: 400;">FOXE1</span></a> <a href="../../snp/rs965513/"><span style="font-weight: 400;">rs965513</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; allele doesn't correlate with hypothyroidism</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; allele correlates with lower rates of hypothyroidism</span></li> </ul> <p><a href="../../gene/foxe1/"><span style="font-weight: 400;">FOXE1</span></a> <a href="../../snp/rs10759944/"><span style="font-weight: 400;">rs10759944</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; allele doesn't correlate with hypothyroidism</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; allele correlates with lower rates of hypothyroidism</span></li> </ul> <p>These four variants are usually inherited together, with the following population frequency:</p> <ul> <li>About 58% of European descendants carry at least one copy of the effect allele</li> <li>About 25% of people of African and East Asian ancestry carry at least one copy of the effect allele</li> </ul> <p>*8175598756178373*</p> <h2><span style="font-weight: 400;">Recommendations to Support the Thyroid</span></h2> <p><span style="font-weight: 400;">Don't forget to consult your doctor before trying any of the strategies below; this post is for informational purposes only.</span></p> <p><span style="font-weight: 400;">*1848933280203126*</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">In one cell-based study, cadmium more than doubled FOXE1 gene expression. Given that lower FOXE1 expression correlates with higer thyroid hormones, make sure to avoid cadmium exposure [</span><a href="https://www.jstage.jst.go.jp/article/jts/36/1/36_1_127/_pdf/-char/en"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a study of over 5,600 Chinese adults, women exposed to more cadmium had higher thyroid antibody levels, which is the culprit of Hashimoto&rsquo;s disease. Sources of cadmium exposure include cigarette smoke, processed and instant foods, and contaminated large ocean fish [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28667913"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056571/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Check out our list of safe and proven </span><a href="https://selfhacked.com/blog/heavy-metals-detox/"><span style="font-weight: 400;">ways to detox cadmium and other heavy metals</span></a><span style="font-weight: 400;">.</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Iron</span></h4> <p><a href="https://selfhacked.com/blog/iron-balance-blood-test-iron-deficiency-anemia-overload/"><span style="font-weight: 400;">Iron</span></a><span style="font-weight: 400;"> is essential for thyroid peroxidase (TPO), which may be suppressed by the FOXE1 gene. Make sure to obtain enough iron by consuming a variety of excellent sources such as [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12487769"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999603/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Meat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Liver</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Dark leafy greens</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Eggs</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/hemp-seeds/" target="_blank" rel="noopener"><span style="font-weight: 400;">Hemp seeds</span></a></li> </ul> <p><span style="font-weight: 400;">Iron deficiency increases the risk of hypothyroidism; supplementation improved </span><a href="https://selfhacked.com/blog/hypothyroidism-may-good-autoimmunity/"><span style="font-weight: 400;">thyroid function</span></a><span style="font-weight: 400;"> in 94 iron-deficient adolescent girls [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19070025"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><span style="font-weight: 400;">Avoid Soy</span></h4> <p><span style="font-weight: 400;">According to animal studies, soy flavonoid genistein </span><strong>inhibits TPO by up to 80%</strong><span style="font-weight: 400;">, so you may want to cut back on soy-based products [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241182/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Clinical trials have found a marginal impact of soy components on thyroid health, but the correlation increases for people with mild hypothyroidism and low </span><a href="https://selfhacked.com/blog/health-benefits-iodine-pregnancy-childhood-diet/"><span style="font-weight: 400;">iodine</span></a><span style="font-weight: 400;"> levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16571087"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141627/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The protective FOXE1 variants likely stimulate the production of thyroid peroxidase (TPO). You can mimic their effects by consuming enough iron and avoiding soy-based products.</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Iron (if deficient) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12487769"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19070025"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p>Please note that iron supplements aren't approved by the FDA to prevent or treat a thyroid disorder. Consult with your doctor before supplementing.</p>
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33 | content_learn_more_5539810132638319_text == Your FOXE1 variants correlate with slightly lower rates of hypothyroidism. Still, you can apply natural strategies to support the thyroid—keep reading for more details.
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rsIDs = rs7850258,rs925489,rs965513,rs10759944
rsStatus = rs7850258,PTCSC2,chr9,97786731,A,G,T,,19,16,HET
rsStatus = rs925489,PTCSC2,chr9,97784318,C,A,G,T,42,1,HET
rsStatus = rs965513,PTCSC2,chr9,97793827,A,C,G,T,31,0,Normal
rsStatus = rs10759944,PTCSC2,chr9,97794690,A,G,,,25,12,HET
