333 | id == 333
333 | category_id == 21
333 | category_order == 18
333 | category_name == Anxiety
333 | category_color == #C47AC0
333 | slug == MSRA-Anxiety
333 | title == Is This Gene Contributing To Your Anxiety Levels? (MSRA)
333 | meta_description == MSRA gene variants may be affecting your anxiety levels. Read on to find out more!
333 | summary == <p style="text-align:justify"><strong><em>MSRA</em> variants may influence your anxiety levels. Read on to find out the impact these variants may be having on you and what you can do to reduce it!</strong></p>
333 | overall_score_text == Your Anxiety Score (based on the MSRA gene)
333 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/BLK-MSRA-Anxiety.jpg
333 | author_id == 13
333 | author_name == Lewis Cuthbertson
333 | author_title == PhD
333 | author_order == 12
333 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
333 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
333 | reviewer == None
333 | medical_reviewer_id == 11
333 | medical_reviewer_name == Puya Yazdi
333 | medical_reviewer_title == MD
333 | publish_date == 2020
333 | publish_date == 9
333 | publish_date == 15
333 | avg_rating == 5.0
333 | tags_id == 112
333 | tags_name == Anxiety
333 | tags_id == 207
333 | tags_name == Exercise
333 | tags_id == 92
333 | tags_name == Magnesium
333 | tags_id == 710
333 | tags_name == MSRA gene
333 | tags_id == 39
333 | tags_name == Oxidative Stress
333 | tags_id == 294
333 | tags_name == Vitamin B12
333 | tags_id == 373
333 | tags_name == Vitamin C
333 | permissions_favorite == False
333 | permissions_rate == False
333 | content_article == <h2 style="text-align: justify;"><span style="font-weight: 400;">Summary</span></h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><a href="../../../gene/msra/"><span style="font-weight: 400;">MSRA</span></a><span style="font-weight: 400;"> gene encodes Methionine sulfoxide reductase enzymes.</span></span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">These enzymes repair damage caused by too much oxygen.&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Oxidative damage may impair the nervous system, leading to anxiety.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Variants may affect enzyme levels, leading to more oxidative stress and anxiety.</span></li> </ul> <h2 style="text-align: justify;"><span style="font-weight: 400;">&nbsp;MSRA and Anxiety</span></h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="../../../gene/msra/"><span style="font-weight: 400;">MSRA</span></a><span style="font-weight: 400;"> (Methionine sulfoxide reductase A) gene encodes Methionine sulfoxide reductase enzymes.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">When damaged by oxidative stress, proteins can become dysfunctional. Methionine sulfoxide reductase enzymes repair oxidative damage&nbsp; [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S1570963904002213?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Oxidative damage to cells may potentially impair the nervous system. This has been linked to anxiety disorder [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763246/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Variants of the gene may affect MSRA levels, impairing the bodies ability to fix oxidative damage. This may impair the nervous system and contribute toward anxiety.</span></li> </ul> <h2 style="text-align: justify;"><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">MSRA</span></em><span style="font-weight: 400;"> Results for Anxiety</span></h2> <h3 style="text-align: justify;">*7887796785136334*</h3> <h3 style="text-align: justify;"><span style="font-weight: 400;">SNP Table and Summary</span></h3> <p style="text-align: justify;"><strong>[</strong><strong><em>MSRA</em></strong><strong>] rs6985109</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = More likely to report feelings of anxiety/worrying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with anxiety/worrying</span></li> </ul> <p style="text-align: justify;"><strong>[</strong><strong><em>MSRA</em></strong><strong>] rs4841662</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = More likely to report feelings of anxiety/worrying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with anxiety/worrying</span></li> </ul> <p style="text-align: justify;"><strong>[</strong><strong><em>MSRA</em></strong><strong>] rs6981523</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = More likely to report feelings of anxiety/worrying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with anxiety/worrying</span></li> </ul> <p style="text-align: justify;"><strong>[</strong><strong><em>MSRA</em></strong><strong>] rs2572431</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = More likely to report feelings of anxiety/worrying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with anxiety/worrying</span></li> </ul> <p style="text-align: justify;"><strong>[</strong><strong><em>MSRA</em></strong><strong>] rs10097870</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = More likely to report feelings of anxiety/worrying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with anxiety/worrying</span></li> </ul> <p style="text-align: justify;"><strong>*8169179024627533*</strong></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Recommendations for Reducing Anxiety</span></h2> <p style="text-align: justify;"><strong>*9949576429679499*</strong></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Lifestyle</span></h3> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Exercise is known to have antioxidant effects which can reduce the likelihood of oxidative stress damage. Exercise is also known to reduce anxiety [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27260682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28088704/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3 style="text-align: justify;"><span style="font-weight: 400;">Supplements</span></h3> <ul> <li style="font-weight: 400; text-align: justify;"><span style="font-weight: 400;">B vitamins, and vitamin B12 in particular, are thought to reduce anxiety. This may be through their association with reducing oxidative stress, which may be caused by </span><em><span style="font-weight: 400;">MSRA </span></em><span style="font-weight: 400;">variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30513795/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;"> ,</span><a href="https://content.sciendo.com/view/journals/jbcr/10/2/article-p140.xml?language=en"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;"> ,</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S1756464617307077"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400; text-align: justify;"><span style="font-weight: 400;">Magnesium chloride has been shown to decrease anxiety, and is also known to reduce oxidative stress [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28654669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32343266/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400; text-align: justify;"><span style="font-weight: 400;">Vitamin C is a well known antioxidant and so may reduce some of the effects of oxidative stress associated with MSRA variants. Vitamin C has been shown to reduce anxiety [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26353411/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> </ul>
333 | content_snp_table_7887796785136334_key == 7887796785136334
333 | content_snp_table_7887796785136334_blur == True
333 | content_snp_table_7887796785136334_hidden == False
333 | content_learn_more_8169179024627533_key == 8169179024627533
333 | content_learn_more_8169179024627533_blur == True
333 | content_learn_more_8169179024627533_hidden == False
333 | content_learn_more_8169179024627533_text == Based on the variants we looked at, your MSRA gene makes you somewhat more likely to develop anxiety. However, this doesn't necessarily reflect your overall risk; it’s just one gene related to it. Keep scrolling to find out more.
333 | content_recommendation_9949576429679499_key == 9949576429679499
333 | content_recommendation_9949576429679499_blur == True
333 | content_recommendation_9949576429679499_hidden == False
rsIDs = rs2572431,rs6981523,rs6985109,rs10097870,rs4841662
rsStatus = rs2572431,LINC00529,chr8,11247568,C,G,T,,3,0,Normal
rsStatus = rs6981523,,chr8,11204283,C,A,T,,7,0,Normal
rsStatus = rs6985109,XKR6,chr8,10904075,G,A,C,T,5,0,Normal
rsStatus = rs10097870,,chr8,11587007,G,A,C,,12,0,Normal
rsStatus = rs4841662,,chr8,11986249,G,A,T,,17,0,Normal
