334 | id == 334
334 | category_id == 21
334 | category_order == 18
334 | category_name == Anxiety
334 | category_color == #C47AC0
334 | slug == ANO2-GABA-anxiety
334 | title == Can This Gene Make You More Anxious? (ANO2)
334 | meta_description == The ANO2 gene enables GABA functions in the brain. Learn about its link with anxiety.
334 | summary == <p style="text-align:justify"><strong>The ANO2 gene enables the release of GABA, a crucial neurotransmitter for mental health. Read this post to learn how an ANO2 variant impacts anxiety.</strong></p>
334 | overall_score_text == Your Anxiety Score (Based on ANO2 Gene)
334 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ANO2-Anxiety.jpg
334 | author_id == 9
334 | author_name == Aleksa Ristic
334 | author_title == MS (Pharmacy)
334 | author_order == 45
334 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
334 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
334 | reviewer == None
334 | medical_reviewer_id == 11
334 | medical_reviewer_name == Puya Yazdi
334 | medical_reviewer_title == MD
334 | publish_date == 2020
334 | publish_date == 9
334 | publish_date == 15
334 | avg_rating == 5.0
334 | tags_id == 712
334 | tags_name == ANO2 gene
334 | tags_id == 112
334 | tags_name == Anxiety
334 | tags_id == 711
334 | tags_name == GABA
334 | tags_id == 713
334 | tags_name == Panic Disorder
334 | permissions_favorite == False
334 | permissions_rate == False
334 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The ANO2 gene enables GABA activity, which is crucial for anxiety prevention.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>One gene variant correlates with anxiety, likely due to low GABA levels.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific lifestyle changes and supplements may reduce anxiety by targeting your variant.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of ANO2 in Anxiety</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/ano2/"><span style="font-weight: 400;">ANO2</span></a><span style="font-weight: 400;"> gene (also known as TMEM16B) enables <a href="https://selfhacked.com/blog/gaba-function/" target="_blank" rel="noopener">GABA</a> functions in the brain [</span><a href="https://www.jneurosci.org/content/39/36/7102"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746550/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Impaired GABA release plays a central role in <a href="https://selfhacked.com/blog/natural-treatments-anxiety/" target="_blank" rel="noopener">anxiety</a> development [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12662130/#:~:text=Anxiety%20stems%20from%20and%20perpetuates,of%20the%20excitatory%20neurotransmitter%20glutamate."><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Animals lacking the ANO2 gene develop anxiety due to low GABA levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746550/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your ANO2 Results for Anxiety</strong></h2> <p>*8212269947942539*</p> <p><strong>Primary SNP:&nbsp;</strong></p> <p><strong>ANO2 </strong><a href="../../../snp/rs12579350/"><strong>rs12579350</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19165232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19960027/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of a panic disorder</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This variant has also been associated with sleep disorders and neuroticism [</span><a href="https://europepmc.org/abstract/med/29292387"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely reduces GABA levels in the brain.</span></li> </ul> <p>*2873620017706657*</p> <h2><strong>Recommendations for Reducing Anxiety</strong></h2> <p>*4212225642348639*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Exercise may help relieve anxiety by boosting </span><a href="https://selfhacked.com/blog/natural-ways-to-increase-gaba/"><span style="font-weight: 400;">GABA</span></a><span style="font-weight: 400;"> in the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31326567/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501262/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People who </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> regularly experience lower levels of neuroticism, anxiety, and depression [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-1843-x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aerobic exercise may be most effective at reducing anxiety in both healthy people and those with a panic disorder or general anxiety [</span><a href="http://www.tandfonline.com/doi/full/10.1080/16506073.2015.1028094"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11148895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28088704"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Regular aerobic exercise may prevent or reduce anxiety by targeting your gene variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Kava</strong></h4> <p><a href="https://selfhacked.com/blog/health-benefits-kava/"><span style="font-weight: 400;">Kava</span></a><span style="font-weight: 400;"> improved anxiety, </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> quality, and tension in multiple clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14692723"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15181652"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9065962"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16428031"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The benefits of kava for mental health stem from increased GABA activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12383029/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630875/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with liver problems should consult with their doctor before taking kava [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15068826"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://livertox.nih.gov/KavaKava.htm#casereport"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Kava may lessen the impact of your gene variants on anxiety.</span></p> <h4><strong>Lavender</strong></h4> <p><a href="https://content.selfdecode.com/blog/lavender-health-benefits/"><span style="font-weight: 400;">Lavender</span></a><span style="font-weight: 400;"> improved anxiety and sleep quality in multiple human studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22475718"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19962288"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20512042"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16131287"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different components of lavender essential oil may reduce anxiety by increasing GABA activity [</span><a href="http://www.sciencedirect.com/science/article/pii/S0006295205000341"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.sciencedirect.com/science/article/pii/S0944711308001529"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://link.springer.com/article/10.2478/s11532-014-0532-4"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
334 | content_snp_table_8212269947942539_key == 8212269947942539
334 | content_snp_table_8212269947942539_blur == True
334 | content_snp_table_8212269947942539_hidden == False
334 | content_learn_more_2873620017706657_key == 2873620017706657
334 | content_learn_more_2873620017706657_blur == True
334 | content_learn_more_2873620017706657_hidden == False
334 | content_learn_more_2873620017706657_text == Based on the variant we looked at, your ANO2 gene is associated with slightly higher odds of a panic disorder. However, this doesn't necessarily reflect your overall risk of a panic disorder or anxiety in general, just one gene related to it. Regular exercise may improve anxiety symptoms by targeting your gene variants. Keep reading to learn more.
334 | content_recommendation_4212225642348639_key == 4212225642348639
334 | content_recommendation_4212225642348639_blur == True
334 | content_recommendation_4212225642348639_hidden == False
rsIDs = rs12579350
rsStatus = rs12579350,ANO2,chr12,5687935,G,A,T,,43,0,Normal
