335 | id == 335
335 | category_id == 21
335 | category_order == 18
335 | category_name == Anxiety
335 | category_color == #C47AC0
335 | slug == TSNARE1-dopamine-anxiety
335 | title == A Less-Known Genetic Factor for Anxiety (TSNARE1)
335 | meta_description == The TSNARE1 gene enables the release of dopamine in the brain. Learn about its link with anxiety.
335 | summary == <p style="text-align:justify"><strong>TSNARE1 enables the release of dopamine and other neurotransmitters in the brain. Read this post to learn how variants in this gene impact anxiety and mental health.</strong></p>
335 | overall_score_text == Your Anxiety Score (Based on TSNARE1 Gene)
335 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ADGRB1-TSNARE1-Anxiety.jpg
335 | author_id == 9
335 | author_name == Aleksa Ristic
335 | author_title == MS (Pharmacy)
335 | author_order == 45
335 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
335 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
335 | reviewer == None
335 | medical_reviewer_id == 11
335 | medical_reviewer_name == Puya Yazdi
335 | medical_reviewer_title == MD
335 | publish_date == 2020
335 | publish_date == 9
335 | publish_date == 16
335 | avg_rating == 5.0
335 | tags_id == 112
335 | tags_name == Anxiety
335 | tags_id == 51
335 | tags_name == Dopamine
335 | tags_id == 716
335 | tags_name == Mental Health
335 | tags_id == 619
335 | tags_name == Schizophrenia
335 | tags_id == 715
335 | tags_name == TSNARE1 gene
335 | permissions_favorite == False
335 | permissions_rate == False
335 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The TSNARE1 gene enables the release of dopamine and other neurotransmitters in the brain. It plays a role in different mental health issues.<br /><br /></strong><strong>TSNARE1 variants correlate with anxiety, likely due to impaired dopamine function.<br /><br /></strong><strong>Specific supplements and lifestyle changes may reduce anxiety by targeting your gene variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of TSNARE1 in Anxiety</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/tsnare1/"><span style="font-weight: 400;">TSNARE1</span></a><span style="font-weight: 400;"> gene enables the release of different neurotransmitters in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778520/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. </span><span style="font-weight: 400;">Changes in this gene&rsquo;s activity correlate with </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and other mental disorders [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24166486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A robust link between TSNARE1 and schizophrenia suggests the potential role of this gene in </span><a href="https://selfhacked.com/blog/dopamine/"><span style="font-weight: 400;">dopamine</span></a><span style="font-weight: 400;"> release [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778520/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24166486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. </span><span style="font-weight: 400;">Impaired dopamine function in the brain is associated with anxiety [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26317601/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30179855/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The TSNARE1 gene may play a role in anxiety and other mental disorders due to changes in dopamine release.</span></p> <p>&nbsp;</p> <h2><strong>Your TSNARE1 Results for Anxiety</strong></h2> <p>*8380085844298275*</p> <p><strong>Primary SNP:</strong></p> <p><strong><a href="https://selfdecode.com/snp/rs4129585/">rs4129585</a></strong><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with anxiety</span></li> </ul> <p><strong>Another Important SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs13262595/"><span style="font-weight: 400;"><strong>rs13262595</strong></span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with anxiety</span></li> </ul> <p><span style="font-weight: 400;">These variants correlate with other mental health issues, such as nervousness, mood swings, and </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/article/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p>*6990877955747421*&nbsp;</p> <p>&nbsp;</p> <h2><strong>Recommendations to Relieve Anxiety</strong></h2> <p>*6502451433148548*&nbsp;</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Cognitive-Behavioral Therapy</strong></h4> <p><span style="font-weight: 400;">Cognitive-behavioral therapy may help with anxiety by balancing dopamine in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It can improve anxiety disorders such as generalized anxiety disorder, panic disorder, and social phobia [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25932596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913603/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19880935"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cognitive-behavioral therapy may be particularly useful given the link between TSNARE1 variants and other mental health issues [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24166486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cognitive-behavioral therapy may lessen the impact of your gene variants on anxiety and mental health in general.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Rhodiola </strong></h4> <p><a href="https://selfhacked.com/blog/rhodiola/"><span style="font-weight: 400;"><em>Rhodiola rosea</em></span></a> may support mental health by boosting dopamine in the brain [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856322/" target="_blank" rel="noopener">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/15548230" target="_blank" rel="noopener">R</a>].</p> <p><span style="font-weight: 400;">Rhodiola extract supplementation improved anxiety and mood in four clinical trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26502953/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22228617/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18307390/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>CBD Oil</strong></h4> <p><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;"> may help with anxiety and other mental disorders by balancing dopamine and </span><a href="https://www.selfhacked.com/blog/how-to-increase-serotonin"><span style="font-weight: 400;">serotonin</span></a><span style="font-weight: 400;"> levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061893/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">CBD reduced anxiety from stressful situations such as public speaking and medical procedures in several clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14583744"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22290374"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425583/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30328956"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It may also help with anxiety from anxiety disorders, autism, and drug use </span><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482919/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/4609777"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/6285406"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31109198"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Note that CBD oil is derived from </span><a href="https://selfhacked.com/blog/top-6-unique-super-effective-ways-counteract-negative-performance-effects-cannabismarijuana/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">cannabis</span></a><span style="font-weight: 400;">, which is a controlled substance in many countries and states. Therefore, make sure to verify the legality of CBD products where you live before seeking them out.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CBD oil may reduce anxiety by targeting your gene variants. Check if CBD-containing products are legal in your country.</span></p>
335 | content_snp_table_8380085844298275_key == 8380085844298275
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335 | content_snp_table_8380085844298275_hidden == False
335 | content_learn_more_6990877955747421_key == 6990877955747421
335 | content_learn_more_6990877955747421_blur == True
335 | content_learn_more_6990877955747421_hidden == False
335 | content_learn_more_6990877955747421_text == Based on the variants we looked at, your TSNARE1 gene is associated with slightly higher odds of anxiety. However, this doesn't necessarily reflect your overall risk of anxiety, just one gene related to it. CBD oil may improve anxiety symptoms by targeting your gene variants. Keep reading to learn more.
335 | content_recommendation_6502451433148548_key == 6502451433148548
335 | content_recommendation_6502451433148548_blur == True
335 | content_recommendation_6502451433148548_hidden == False
rsIDs = rs4129585,rs13262595
rsStatus = rs4129585,TSNARE1,chr8,142231572,A,C,G,,5,21,HET
rsStatus = rs13262595,TSNARE1,chr8,142235609,A,C,G,T,34,0,Normal
