337 | id == 337
337 | category_id == 21
337 | category_order == 18
337 | category_name == Anxiety
337 | category_color == #C47AC0
337 | slug == PITX2-GABA-anxiety
337 | title == Genetic Link Between Stress Response & Anxiety (PITX1)
337 | meta_description == The PITX1 gene ensures an optimal stress response. Learn about its link with anxiety.
337 | summary == <p style="text-align:justify"><strong>Your genes may be hindering stress response, which is crucial for mental health. Read this post to learn how the PITX1&nbsp;gene impacts stress hormones and anxiety.</strong></p>
337 | overall_score_text == Your Anxiety Score (Based on PITX1 Gene)
337 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PITX2_Anxiety.jpg
337 | author_id == 9
337 | author_name == Aleksa Ristic
337 | author_title == MS (Pharmacy)
337 | author_order == 45
337 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
337 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
337 | reviewer == None
337 | medical_reviewer_id == 11
337 | medical_reviewer_name == Puya Yazdi
337 | medical_reviewer_title == MD
337 | publish_date == 2020
337 | publish_date == 9
337 | publish_date == 17
337 | avg_rating == 5.0
337 | tags_id == 112
337 | tags_name == Anxiety
337 | tags_id == 460
337 | tags_name == Brain Development
337 | tags_id == 416
337 | tags_name == Cortisol
337 | tags_id == 716
337 | tags_name == Mental Health
337 | tags_id == 1169
337 | tags_name == PITX1 gene
337 | tags_id == 50
337 | tags_name == Stress
337 | permissions_favorite == False
337 | permissions_rate == False
337 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The PITX1 gene controls the production of stress hormones, which play a crucial role in mental health.<br /><br /></strong><strong>One gene variant correlates with higher odds of anxiety, likely due to an impaired stress response.<br /><br /></strong><strong>Specific supplements and lifestyle changes may reduce anxiety by targeting your gene variant.</strong></span></p> <h2><strong>The PITX1 Gene in Anxiety</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/pitx1/"><span style="font-weight: 400;">PITX1</span></a><span style="font-weight: 400;"> gene ensures optimal <a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/" target="_blank" rel="noopener">stress</a> response by controlling the production of stress hormones such as <a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/" target="_blank" rel="noopener">cortisol</a> and <a href="https://selfhacked.com/blog/acth/" target="_blank" rel="noopener">ACTH</a></span><span style="font-weight: 400;">&nbsp;[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222245/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Impaired stress response plays a crucial role in the development of </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> disorders [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2235645/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your PITX1 Results for Anxiety</strong></h2> <p>*2560296035825877*</p> <p><strong>Primary SNP:</strong></p> <p><strong>PITX1 </strong><a href="https://selfdecode.com/snp/rs254560/"><strong>rs254560</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24047446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This variant likely impairs PITX1 activity and stress response</span><span style="font-weight: 400;">.</span></li> </ul> <p>*8704615276688046*&nbsp;</p> <h2><strong>Recommendations to Reduce Anxiety</strong></h2> <p>*5647519054068071*</p> <h3><strong>Exercise</strong></h3> <p><span style="font-weight: 400;">Exercise may help relieve anxiety by reducing stress and balancing cortisol and ACTH levels</span><span style="font-weight: 400;">&nbsp;[</span><a href="https://pubmed.ncbi.nlm.nih.gov/30570106/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18787373/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People who </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> regularly experience lower levels of neuroticism, anxiety, and </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-1843-x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aerobic exercise and </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> may be most effective at reducing anxiety in both healthy people and those with a diagnosed anxiety disorder [</span><a href="http://www.tandfonline.com/doi/full/10.1080/16506073.2015.1028094"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11148895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28088704"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://journals.sagepub.com/doi/abs/10.2466/pms.109.3.924-930"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19341989"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Regular aerobic exercise may prevent or reduce anxiety by targeting your gene variants.</span></p> <h3><strong>Aromatherapy</strong></h3> <p><span style="font-weight: 400;">Preliminary research in humans shows that aromatherapy may help reduce anxiety and tension [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25234160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different essential oils, especially those of </span><a href="https://selfhacked.com/blog/lavender-health-benefits/"><span style="font-weight: 400;">lavender</span></a><span style="font-weight: 400;"> and sweet orange, can reduce </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> by balancing cortisol levels and activating GABA receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18635155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16095639/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22849536/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32185802/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099651/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Chamomile</strong></h3> <p><a href="https://content.selfdecode.com/blog/health-benefits-chamomile/"><span style="font-weight: 400;">Chamomile</span></a><span style="font-weight: 400;"> extract may reduce mild-to-moderate anxiety, depression, and stress without causing excessive sedation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600408/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600416/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16628544"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Chamomile owes its anti-anxiety effects to the flavonoid </span><a href="http://selfhacked.com/blog/top-11-science-based-health-benefits-apigenin/"><span style="font-weight: 400;">apigenin</span></a><span style="font-weight: 400;">, which improves stress response by reducing cortisol and ACTH levels&nbsp; [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11578656"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242113/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
337 | content_snp_table_2560296035825877_key == 2560296035825877
337 | content_snp_table_2560296035825877_blur == True
337 | content_snp_table_2560296035825877_hidden == False
337 | content_learn_more_8704615276688046_key == 8704615276688046
337 | content_learn_more_8704615276688046_blur == True
337 | content_learn_more_8704615276688046_hidden == False
337 | content_learn_more_8704615276688046_text == Based on the variant we looked at, your PITX2 gene is associated with slightly higher odds of anxiety. However, this doesn't necessarily reflect your overall risk of anxiety, just one gene related to it. Regular exercise, chamomile, and other natural remedies may improve anxiety symptoms by targeting your gene variants. Keep reading to learn more.
337 | content_recommendation_5647519054068071_key == 5647519054068071
337 | content_recommendation_5647519054068071_blur == True
337 | content_recommendation_5647519054068071_hidden == False
rsIDs = rs254560
rsStatus = rs254560,PITX1-AS1,chr5,135107916,G,A,,,40,0,Normal
