338 | id == 338
338 | category_id == 21
338 | category_order == 18
338 | category_name == Anxiety
338 | category_color == #C47AC0
338 | slug == PKP1-anxiety
338 | title == A Surprising Genetic Factor for Anxiety (PKP1)
338 | meta_description == The PKP1 gene has shown surprising associations with different mental health disorders. Learn about its link with anxiety.
338 | summary == <p style="text-align:justify"><strong>What does skin development have to do with anxiety? They are influenced by the same gene! Read this post to learn about the role of the PKP1 gene in a panic disorder.</strong></p>
338 | overall_score_text == Your Anxiety Score (Based on PKP1 Gene)
338 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PKP1-Anxiety.jpg
338 | author_id == 9
338 | author_name == Aleksa Ristic
338 | author_title == MS (Pharmacy)
338 | author_order == 45
338 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
338 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
338 | reviewer == None
338 | medical_reviewer_id == 11
338 | medical_reviewer_name == Puya Yazdi
338 | medical_reviewer_title == MD
338 | publish_date == 2020
338 | publish_date == 9
338 | publish_date == 17
338 | avg_rating == 5.0
338 | tags_id == 112
338 | tags_name == Anxiety
338 | tags_id == 716
338 | tags_name == Mental Health
338 | tags_id == 12
338 | tags_name == Mood
338 | tags_id == 718
338 | tags_name == PKP1 gene
338 | tags_id == 485
338 | tags_name == Sleep
338 | permissions_favorite == False
338 | permissions_rate == False
338 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>PKP1 variants correlate with anxiety, sleep issues, and mental disorders, but the exact roles of this gene in the brain are still unknown.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>One gene variant is associated with higher odds of a panic disorder, a type of anxiety disorder.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific lifestyle changes and supplements may help with anxiety and other PKP1-associated conditions.</strong></span></p> <p>&nbsp;</p> <h2><strong>The PKP1 Gene and Anxiety</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/pkp1/"><span style="font-weight: 400;">PKP1</span></a><span style="font-weight: 400;"> gene is responsible for skin health and development [</span><a href="https://ghr.nlm.nih.gov/gene/PKP1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">PKP1 variants correlate with </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;">, mental disorders, and </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> issues but the exact roles of this gene in the brain are still unknown [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/27046643"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Given the above associations, <strong>PKP1 is likely involved in overall brain functions and helps maintain optimal cognition &amp; mental health</strong>.</span></p> <h2><strong>Your PKP1 Results for Anxiety</strong></h2> <p>*1388983695120558*</p> <p><strong>Primary SNP:&nbsp;</strong></p> <p><strong>PKP1 </strong><a href="../../../snp/rs860554/"><strong>rs860554</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19165232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19960027/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of a panic disorder</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with a panic disorder</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This SNP is also associated with unstable mood, sleep issues, cognitive impairment, and more [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/27046643"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*7119390745883316*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Relieve Anxiety</strong></h2> <p>*4456676017618077*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Cognitive-Behavioral Therapy</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Cognitive-behavioral therapy can help with a panic disorder and other types of anxiety disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25932596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">It can target the PKP1 variant by addressing the underlying sleep, mental, or cognitive issues [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584580/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797481/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><strong>Supplements</strong></h3> <h4><strong>Lavender</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">An oral preparation with </span><a href="https://content.selfdecode.com/blog/lavender-health-benefits/"><span style="font-weight: 400;">lavender</span></a><span style="font-weight: 400;"> oil improved anxiety in several clinical studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22475718"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19962288"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20512042"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Lavender may also target the PKP1 gene by improving mood and sleep quality [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20512042"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443384/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/27095995"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Aromatherapy with lavender oil (massage or inhalation) is beneficial for a range of PKP1-associated conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007527/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aromatherapy or supplementation with lavender oil may help with anxiety and other PKP1-associated conditions.</span></p> <h4><strong>Ginkgo</strong></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/ginkgo-biloba/"><em><span style="font-weight: 400;">Ginkgo biloba</span></em></a><span style="font-weight: 400;"> may reduce anxiety, according to human and animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16808927"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/9551771"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/26092515"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">It&rsquo;s a great choice for people with the PKP1 variant, given its versatile benefits for mental health and cognition [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/26092515"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK541024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679686/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul>
338 | content_snp_table_1388983695120558_key == 1388983695120558
338 | content_snp_table_1388983695120558_blur == True
338 | content_snp_table_1388983695120558_hidden == False
338 | content_learn_more_7119390745883316_key == 7119390745883316
338 | content_learn_more_7119390745883316_blur == True
338 | content_learn_more_7119390745883316_hidden == False
338 | content_learn_more_7119390745883316_text == Based on the variant we looked at, your PKP1 gene is associated with slightly higher odds of a panic disorder. However, this doesn't necessarily reflect your overall risk of a panic disorder or anxiety, just one gene related to it. Lavender and ginkgo may improve anxiety symptoms by targeting your gene variants. Keep reading to learn more.
338 | content_recommendation_4456676017618077_key == 4456676017618077
338 | content_recommendation_4456676017618077_blur == True
338 | content_recommendation_4456676017618077_hidden == False
rsIDs = rs860554
rsStatus = rs860554,PKP1,chr1,201293304,C,G,T,,35,0,Normal
