339 | id == 339
339 | category_id == 21
339 | category_order == 18
339 | category_name == Anxiety
339 | category_color == #C47AC0
339 | slug == CAMTA1-IT1-anxiety
339 | title == Can Memory Influence Anxiety? (CAMTA1-IT1)
339 | meta_description == CAMTA1-IT1 plays a role in episodic memory. A variant of CAMTA1-IT1 has been associated with anxiety. Read more here.
339 | summary == <p style="text-align:justify"><strong>The <em>CAMTA1-IT1</em> gene regulates the production of CAMTA1, a protein important for&nbsp;the storage and recollection of personal facts and experiences (episodic memory). A variant of <em>CAMTA1-IT1</em> has been associated with relative increased propensity for anxiety. Read more to learn about the association between episodic memory and anxiety, and about some recommendations you can follow to mitigate the negative effect of this variant.</strong></p>
339 | overall_score_text == Your Anxiety Score (based on CAMTA1-IT1 gene)
339 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CAMTA1-Anxiety.jpg
339 | author_id == 14
339 | author_name == Shany Lahan
339 | author_title == MS (Neuroscience)
339 | author_order == 5
339 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
339 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
339 | reviewer == None
339 | medical_reviewer_id == 11
339 | medical_reviewer_name == Puya Yazdi
339 | medical_reviewer_title == MD
339 | publish_date == 2020
339 | publish_date == 9
339 | publish_date == 18
339 | avg_rating == 5.0
339 | tags_id == 112
339 | tags_name == Anxiety
339 | tags_id == 720
339 | tags_name == CAMTA1 Gene
339 | tags_id == 719
339 | tags_name == CAMTA1-IT1 Gene
339 | tags_id == 13
339 | tags_name == Cognition
339 | tags_id == 721
339 | tags_name == Episodic Memory
339 | permissions_favorite == False
339 | permissions_rate == False
339 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">CAMTA1-IT1 </span></em><span style="font-weight: 400;">gene regulates the production of CAMTA1, a protein necessary for the storage and recollection of personal facts and experiences (episodic memory). A variant of </span><em><span style="font-weight: 400;">CAMTA1-IT1 </span></em><span style="font-weight: 400;">may play a role in anxiety by promoting episodic memory dysfunction. Lifestyle modifications can counteract the effect of this variant by altering maladaptive thinking patterns.</span></span></p> <h2 style="text-align: justify;"><strong><em>CAMTA1-IT1</em> and Anxiety</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">CAMTA1-IT1 </span></em><span style="font-weight: 400;">gene does not code for a protein itself, and instead regulates the production of another protein: CAMTA1. Similarly, CAMTA1 binds DNA in order to regulate the production of other proteins [</span><a href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMTA1-IT1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ghr.nlm.nih.gov/gene/CAMTA1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Previous studies have demonstrated the importance of CAMTA1 in </span><a href="https://selfhacked.com/blog/different-types-memory/"><span style="font-weight: 400;">episodic memory</span></a><span style="font-weight: 400;">. Episodic memory can be defined as the storage and recollection of personal facts and experiences [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17470457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880143/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Dysfunction of episodic memory is commonly observed in anxiety disorders. One example of an episodic memory dysfunction in individuals prone to anxiety is the constant, biased recollection of past threatening or traumatic (emotional) personal experiences, which can govern the anxious thoughts and behaviors of these individuals [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15589570/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005957/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005957/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">CAMTA1-IT1 </span></em><span style="font-weight: 400;">has been associated with anxiety. Although the mechanism behind this association is unknown, it&rsquo;s possible that this </span><em><span style="font-weight: 400;">CAMTA1-IT1 </span></em><span style="font-weight: 400;">variant may result in dysregulation of CAMTA1 production, leading to dysfunction in episodic memory and increasing the propensity for anxiety (relative to other </span><em><span style="font-weight: 400;">CAMTA1-IT1 </span></em><span style="font-weight: 400;">variants) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24047446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your <em>CAMTA1-IT1</em> Results for Anxiety</strong></h2> <p style="text-align: justify;">*3635844681689695*</p> <p style="text-align: justify;"><strong>Primary SNP: </strong><strong><em>CAMTA1-IT1</em></strong> <a href="../../../snp/rs11120917/"><strong>rs11120917</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased propensity for anxiety, relative to &lsquo;T&rsquo; allele</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Decreased propensity for anxiety, relative to &lsquo;C&rsquo; allele</span></li> </ul> <p style="text-align: justify;">*4396761941482532*</p> <h2 style="text-align: justify;"><strong>Recommendations for Reducing Anxiety</strong></h2> <p style="text-align: justify;">*6549459716162542*</p> <p style="text-align: justify;"><span style="font-weight: 400;">While individuals prone to anxiety are more likely to recollect personal experiences that contain emotional content, they are also less likely to store personal experiences that contain neutral content. Therefore, rather than trying to weaken or strengthen their episodic memory, individuals with risk variants of </span><em><span style="font-weight: 400;">CAMTA1-IT1 </span></em><span style="font-weight: 400;">should focus on modifying their maladaptive thinking patterns.</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Cognitive-Behavioral Therapy (CBT)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cognitive-behavioral therapy is a technique that aims to reduce anxiety in individuals by promoting awareness of their maladaptive thinking patterns and behaviors [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25932596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Cognitive-behavioral therapy has been shown to improve symptoms of anxiety in a variety of anxiety disorders, especially when combined with medication [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913603/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19880935"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cognitive-behavioral therapy may reduce anxiety by modifying maladaptive thinking patterns.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Cognitive Bias Modification</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cognitive bias modification has a goal similar to cognitive-behavioral therapy, but it does not require individuals to discuss personal issues in order to reduce anxiety [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516492/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Limited research shows that cognitive bias modification may decrease negative automatic thoughts and reduce anxiety [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27450074"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653919/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cognitive bias modification may reduce anxiety by modifying maladaptive thinking patterns. </span></p>
339 | content_snp_table_3635844681689695_key == 3635844681689695
339 | content_snp_table_3635844681689695_blur == True
339 | content_snp_table_3635844681689695_hidden == False
339 | content_learn_more_4396761941482532_key == 4396761941482532
339 | content_learn_more_4396761941482532_blur == True
339 | content_learn_more_4396761941482532_hidden == False
339 | content_learn_more_4396761941482532_text == Based on the variants we looked at, your CAMTA1-IT1 gene makes you somewhat more prone to anxiety, relative to other variants. However, this doesn't necessarily reflect your overall risk of anxiety; it’s just one gene related to it. Cognitive-behavioral therapy (CBT) and cognitive bias modification may help. Keep scrolling to find out more.
339 | content_recommendation_6549459716162542_key == 6549459716162542
339 | content_recommendation_6549459716162542_blur == True
339 | content_recommendation_6549459716162542_hidden == False
rsIDs = rs11120917
rsStatus = rs11120917,CAMTA1,chr1,7418016,C,T,,,30,0,Normal
