34 | id == 34
34 | category_id == 4
34 | category_order == 1
34 | category_name == Brain
34 | category_color == #C47AC0
34 | slug == Protect-Your-Dopamine-Neurons-With-LMX1A
34 | title == Boost Your Cognitive Ability By Protecting Your Dopamine Neurons (LMX1A)
34 | meta_description == The LMX1A gene helps maintain the health & efficiency of your brain’s dopamine neurons. Learn how to optimize LMX1A here!
34 | summary == <p style="text-align:justify"><strong>Dopamine is a key player in important cognitive functions such as working memory and cognitive flexibility. In this post, we&rsquo;ll be looking at a gene that helps protect your dopamine neurons from stress and damage, which in turn can have a significant impact on your overall cognitive ability! Read on to learn more about your genotype for the <em>LMX1A</em> gene, and how you can optimize it.</strong></p>
34 | overall_score_text == Your cognitive function score (based on LMX1A gene)
34 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Boost-Your-Cognitive-Ability-By-Protecting-Your-Dopamine-Neurons-LMX1A_JPG.jpg
34 | author_id == 4
34 | author_name == Matt Carland
34 | author_title == PhD
34 | author_order == 10
34 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Matt.jpg
34 | author_intro == <p><strong>Matt received his PhD at the Universit&eacute; de Montr&eacute;al in Neuroscience.</strong></p>    <p>Matt holds multiple degrees in psychology, cognitive science, and neuroscience. He has over a decade of experience in academic research and has published a number of articles in scholarly journals. He currently works as a neuropsychologist in Montreal, where he performs research on the links between personality traits and the development of clinical disorders such as addiction, compulsive gambling, and disordered eating.</p>
34 | reviewer_id == 2
34 | reviewer_name == Joe Cohen
34 | reviewer_title == BS
34 | medical_reviewer_id == 11
34 | medical_reviewer_name == Puya Yazdi
34 | medical_reviewer_title == MD
34 | publish_date == 2019
34 | publish_date == 9
34 | publish_date == 2
34 | avg_rating == 5.0
34 | tags_id == 13
34 | tags_name == Cognition
34 | tags_id == 55
34 | tags_name == Cognitive Flexibility
34 | tags_id == 51
34 | tags_name == Dopamine
34 | tags_id == 28
34 | tags_name == Intelligence
34 | tags_id == 108
34 | tags_name == LMX1A Gene
34 | tags_id == 110
34 | tags_name == Mitochondria
34 | tags_id == 39
34 | tags_name == Oxidative Stress
34 | tags_id == 109
34 | tags_name == Working Memory
34 | permissions_favorite == False
34 | permissions_rate == False
34 | content_article == <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong><span style="font-weight: 400;"> The </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene is one of the 45 unique intelligence-related genes that we analyze in our comprehensive </span><a href="https://get.selfdecode.com/mind-protocol-nm/"><strong><em>Cognitive Function DNA Wellness Report</em></strong></a><span style="font-weight: 400;">. If you&rsquo;re interested in learning more about the genes that affect your cognitive ability, and the actionable steps that you can take to boost your cognition even further, check it out!</span></td> </tr> </tbody> </table> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><span style="font-weight: 400;"><strong>What Does The </strong><strong><em>LMX1A</em></strong><strong> Gene Do?</strong></span></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/blog/gene/lmx1a/"><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> codes for a protein called </span><em><span style="font-weight: 400;">LIM homeobox transcription factor 1-alpha</span></em><span style="font-weight: 400;">. This gene and its protein play different roles at different stages of life.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In early development &mdash; meaning before birth, and during the first few months of life &mdash;&nbsp; the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene stimulates the growth </span><a href="https://selfhacked.com/blog/dopamine/"><strong>dopamine</strong></a><span style="font-weight: 400;"> neurons in the developing brain</span> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27407143"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19189040"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20570600"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In other words, how active this gene is when your brain is just starting to grow essentially determines how many dopamine neurons you will have later on in life!</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although its role in creating neurons is already finished by early childhood, </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> continues to play an important role throughout adulthood and later life by protecting your dopamine neurons from </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><strong>oxidative stress</strong></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/mitochondria/"><strong>mitochondrial dysfunction</strong></a><span style="font-weight: 400;">. This helps keep neurons healthy, which supports overall cognitive function [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27407143"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The activity of the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene early in your life determines how many dopamine neurons you will eventually have &mdash; and later on, it helps keep these neurons alive and healthy by protecting them against damage and stress.</span></span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>Why Is The </strong><strong><em>LMX1A</em></strong><strong> Gene Important?</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene is important for cognitive function because dopamine &mdash; and the neurons that produce and secrete it &mdash; are vital for several key aspects of cognitive function, such as </span><a href="https://selfhacked.com/blog/different-types-memory/"><span style="font-weight: 400;">working memory</span></a><span style="font-weight: 400;"> and cognitive flexibility [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19383789"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21435346"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">When it comes to protecting these dopamine neurons, this gene primarily affects the efficiency of your cell&rsquo;s energy-producing </span><a href="https://selfhacked.com/blog/mitochondria/"><span style="font-weight: 400;">mitochondria</span></a><span style="font-weight: 400;">. Low levels of </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> cause mitochondria to become &ldquo;tired out&rdquo; more easily when your cells need a lot of energy &mdash; and when your mitochondria have to work harder, they produce significantly more </span><strong><em>reactive oxygen species</em></strong><span style="font-weight: 400;"> (ROS), the cellular waste products that cause </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27407143"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19189040"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">If ROS levels get high enough, they can overwhelm your neurons&rsquo; natural antioxidant defenses, resulting in cellular damage or even cell death. Although this is bad news for any cell in your brain, </span><strong>oxidative stress is especially dangerous to dopamine neurons</strong><span style="font-weight: 400;">, due to their generally higher levels of activity compared to other types of neurons [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27407143"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19189040"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Therefore, having adequate </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene activity is very important for making sure that your dopamine neurons aren&rsquo;t being constantly stressed out and damaged! This is probably why SNPs in the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene have been associated with many different important aspects of cognitive function such as learning, multiple different </span><a href="https://selfhacked.com/blog/different-types-memory/"><span style="font-weight: 400;">types of memory</span></a><span style="font-weight: 400;">, and even overall intelligence (IQ) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26534905"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21435346"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17072305"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Dopamine neurons are some of the more delicate types of neurons you have in your brain &mdash; and the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene plays a crucial role in keeping them healthy, thereby supporting optimal cognitive function.</span></span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>LMX1A</em></strong><strong> Genotype</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">You can see your genotype for the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> SNP </span><a href="https://selfdecode.com/blog/snp/rs11809911/"><strong>rs11809911</strong></a><span style="font-weight: 400;"> in the table below:</span></p> <p style="text-align: justify;">*9698560063818775*</p> <p style="text-align: justify;">*2950049424674548*</p> <p style="text-align: justify;"><span style="font-weight: 400;"><br />The two possible alleles for this SNP are &lsquo;C&rsquo; (major) and &lsquo;T&rsquo; (minor). </span><strong>When it comes to optimal cognitive function, it&rsquo;s better to have the &lsquo;CC&rsquo; genotype</strong><span style="font-weight: 400;"> (which about 35% of people have).</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, a gene-targeted study in 218 participants found that the &lsquo;T&rsquo; allele was associated with reduced performance on a wide variety of cognitive tests, including tests of learning and memory, cognitive flexibility (executive function and attention), processing speed, and even general intelligence (IQ) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26534905"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although this particular study only reported this effect for bipolar patients, this result also agrees with several other studies linking risk factors in the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene to differences in cognitive performance among otherwise healthy people.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, people with better-functioning copies of this gene show enhanced performance on tests of working memory, and also achieve higher levels of improvement in their working memory after going through cognitive training programs [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21435346"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This result is particularly interesting, as working memory is one of the cognitive functions most strongly associated with dopamine. In fact, the authors of this study concluded that these cognitive benefits were most likely due to higher number of dopamine neurons in the beneficial </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> genotype group &mdash; which fits very well with what we know about the general role of this gene in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21435346"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27407143"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19189040"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Finally, </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> risk factors have also been linked with increased risk of developing schizophrenia and Parkinson&rsquo;s disease &mdash; two disorders which not only involve cognitive deficits, but which are also directly caused by the dysfunction or widespread loss of dopamine neurons, specifically [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20570600"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27407143"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Taking all these findings into consideration, it is likely that people with the &lsquo;CC&rsquo; genotype for this </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> SNP have a copy of this gene that is more active, which in turn helps them maintain a larger number of healthy dopamine neurons. In contrast, the &lsquo;T&rsquo; allele likely causes the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene to work less efficiently, which impairs cognitive performance by causing dopamine neurons to be more vulnerable to stress, cell damage, and even death.</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with the &lsquo;CC&rsquo; genotype for </span><strong>rs11809911</strong><span style="font-weight: 400;"> show enhanced cognitive performance, likely because their version of the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene is more active. In contrast, carriers of the &lsquo;T&rsquo; allele likely have a less effective version of this gene, making their dopamine neurons more vulnerable to stress and damage.</span></span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>How Can You Improve Your </strong><strong><em>LMX1A</em></strong><strong> Gene?</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">If you carry risk alleles in this SNP, don&rsquo;t worry! There are several effective ways you can balance out your elevated risk of dopamine-related cognitive impairments.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Because higher levels of the </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene help reduce oxidative stress by making sure your cell&rsquo;s mitochondria are working efficiently, there are </span><strong>three main ways to counteract the potential negative effects of risk factors in this gene:</strong></p> <ol style="text-align: justify;"> <li style="font-weight: 400;"><strong>Increasing your levels of <em>LMX1A</em></strong></li> <li style="font-weight: 400;"><strong>Reducing oxidative stress</strong></li> <li style="font-weight: 400;"><strong><a href="https://selfhacked.com/blog/natural-ways-to-improve-mitochondrial-function/">Boosting mitochondrial function</a></strong></li> </ol> <p>*4961526815736361*</p> <h5><strong>PQQ</strong></h5> <p style="text-align: justify;"><strong>Supplementing with </strong><a href="https://selfhacked.com/blog/pqq-review/"><strong><em>pyrroloquinoline quinone</em></strong></a><strong>, or PQQ, is a great way to accomplish all three of these goals at the same time.</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">Firstly, PQQ supplements can help boost your levels of </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> directly. This is because PQQ boosts </span><a href="https://selfdecode.com/blog/gene/nrf1/"><em><span style="font-weight: 400;">NRF1</span></em></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">nuclear respiratory factor 1</span></em><span style="font-weight: 400;">), another key gene involved in antioxidant defense &mdash; and </span><em><span style="font-weight: 400;">NRF1</span></em><span style="font-weight: 400;">, in turn, increases </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19861415"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, animals with reduced </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> gene levels show widespread death of dopamine neurons &mdash; but this damage could be completely stopped in its tracks by boosting their levels of the </span><em><span style="font-weight: 400;">NRF1</span></em><span style="font-weight: 400;"> gene, which in turn brings their </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> levels back up to normal [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27407143"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Secondly, PQQ also reduces oxidative stress and boosts mitochondrial function &mdash; the two other major negative effects of low </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24231099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18231627"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19861415"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Finally, multiple animal studies have linked PQQ supplementation with cognitive enhancements, such as improved learning and memory. These benefits are likely due to PQQ&rsquo;s direct role in counteracting oxidative stress and enhancing mitochondrial function [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27109337"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19861415"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18231627"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8401318"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29891841"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Additionally, two separate studies have reported that supplementing with PQQ enhances attention, working memory, and cognitive flexibility in healthy older adults [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26782228"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27526146"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h5 style="text-align: justify;"><strong>DHA / Fish Oil</strong></h5> <p style="text-align: justify;"><strong>Another great compound to supplement with to counteract your genotype is </strong><strong><em>docosahexaenoic acid</em></strong><strong>, or </strong><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><strong>DHA</strong></a><strong>.</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, DHA boosts the </span><em><span style="font-weight: 400;">NRF1</span></em><span style="font-weight: 400;"> gene, which in turn increases </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> levels. It also enhances mitochondrial function and protects against oxidative stress. Therefore, similar to PQQ, DHA can also help target all the different potential negative effects of </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> risk alleles [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28078253"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15672635"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24860731"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23439385"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">DHA has also been shown to boost many aspects of cognitive function in healthy adults of all ages, including overall cognitive ability, processing speed, cognitive flexibility, and working memory [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20181791"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23515006"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23056476"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20434961"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Therefore, we highly recommend taking supplements that are rich in DHA and other omega-3 </span><em><span style="font-weight: 400;">polyunsaturated fatty acids</span></em><span style="font-weight: 400;"> (PUFAs), such as </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><strong>fish oil</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18541548"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Algae oil and </span><a href="https://selfhacked.com/blog/krill-oil-benefits/"><span style="font-weight: 400;">krill oil</span></a><span style="font-weight: 400;"> can also be good alternative sources for some of these compounds [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22113870"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. You can also obtain DHA from your diet, for example by eating more fish.</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The best ways to counteract </span><em><span style="font-weight: 400;">LMX1A</span></em><span style="font-weight: 400;"> risk factors are to take supplements that increase this gene, while also boosting mitochondrial function and fighting oxidative stress in general.</span></span></p>
34 | content_snp_table_9698560063818775_key == 9698560063818775
34 | content_snp_table_9698560063818775_blur == True
34 | content_snp_table_9698560063818775_hidden == False
34 | content_learn_more_2950049424674548_key == 2950049424674548
34 | content_learn_more_2950049424674548_blur == True
34 | content_learn_more_2950049424674548_hidden == False
34 | content_learn_more_2950049424674548_text == Your genotype for this SNP is associated with slightly reduced cognitive ability, likely due to having a copy of the LMX1A gene that is slightly less efficient than optimal. To find out what you can do to counteract this, see your personalized recommendations below.
34 | content_recommendation_4961526815736361_key == 4961526815736361
34 | content_recommendation_4961526815736361_blur == True
34 | content_recommendation_4961526815736361_hidden == False
rsIDs = rs11809911
rsStatus = rs11809911,LMX1A,chr1,165319120,T,C,,,23,0,Normal
