344 | id == 344
344 | category_id == 21
344 | category_order == 18
344 | category_name == Anxiety
344 | category_color == #C47AC0
344 | slug == EFHC2-anxiety
344 | title == Can This Gene Increase Your Proneness To Anxiety? (EFHC2)
344 | meta_description == EFHC2 gene variants may be affecting your anxiety levels. Read on to find out more!
344 | summary == <p style="text-align:justify"><strong><em>EFHC2</em> variants may influence your anxiety levels. Read on to find out the impact these variants may be having on you and what you can do to reduce it!</strong></p>
344 | overall_score_text == Your Anxiety Score (based on EFHC2 gene)
344 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/EFHC2-Anxiety.jpg
344 | author_id == 13
344 | author_name == Lewis Cuthbertson
344 | author_title == PhD
344 | author_order == 12
344 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
344 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
344 | reviewer == None
344 | medical_reviewer_id == 11
344 | medical_reviewer_name == Puya Yazdi
344 | medical_reviewer_title == MD
344 | publish_date == 2020
344 | publish_date == 9
344 | publish_date == 23
344 | avg_rating == 5.0
344 | tags_id == 112
344 | tags_name == Anxiety
344 | tags_id == 560
344 | tags_name == Calcium
344 | tags_id == 416
344 | tags_name == Cortisol
344 | tags_id == 732
344 | tags_name == EFHC2
344 | permissions_favorite == False
344 | permissions_rate == False
344 | content_article == <h2 style="text-align: justify;"><span style="font-weight: 400;">Summary</span></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><a href="../../../gene/efhc2/"><em><span style="font-weight: 400;">EFHC2</span></em></a><span style="font-weight: 400;"> (EF-hand domain containing 2) gene encodes for a protein which binds to calcium and assists in calcium transport in and out of cells. </span><span style="font-weight: 400;">Variants of the </span><em><span style="font-weight: 400;">EFHC2</span></em><span style="font-weight: 400;"> gene have been associated with general proneness to anxiety and harm avoidance, which is effectively worrying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19429002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24047446/"><span style="font-weight: 400;">R</span></a>, <a href="https://pubmed.ncbi.nlm.nih.gov/17164267/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Whilst the exact function of the proteins produced by the </span><em><span style="font-weight: 400;">EFHC2</span></em><span style="font-weight: 400;"> gene is currently unknown, it is likely that genetic variants impact the availability of calcium in the brain, having a negative overall impact on neuronal health and function, possibly through an increase in cortisol levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481314/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19429002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></span></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">EFHC2</span></em><span style="font-weight: 400;"> Results for Anxiety</span></h2> <h3 style="text-align: justify;">*3186287353465369*</h3> <h3 style="text-align: justify;"><span style="font-weight: 400;">SNP Table and Summary</span></h3> <p style="text-align: justify;"><strong>[</strong><strong><em>EFHC2</em></strong><strong>] rs5906966</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with proneness to anxiety [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24047446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with anxiety</span></li> </ul> <p style="text-align: justify;"><strong>[</strong><strong><em>EFHC2</em></strong><strong>] rs1562875</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with worrying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19429002/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with worrying</span></li> </ul> <p style="text-align: justify;"><strong>*5699752804329306*</strong></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Recommendations for Reducing Anxiety</span></h2> <p style="text-align: justify;"><strong>*3093032383548102*</strong></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Lifestyle</span></h3> <h4 style="text-align: justify;"><span style="font-weight: 400;">Yoga</span></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">A large body of evidence supports the benefits of </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> in reducing anxiety [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26228429"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://journals.sagepub.com/doi/abs/10.2466/pms.109.3.924-930"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19341989"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Specifically, 8 weeks of yoga was shown to reduce cortisol levels and self reported anxiety amongst a host of other health benefits in one trial [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27794449/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3 style="text-align: justify;"><span style="font-weight: 400;">Diet</span></h3> <h4 style="text-align: justify;"><span style="font-weight: 400;">No Late Night Snacking</span></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Snacking late at night (after 10pm), was found to have a host of negative health impacts, including increased anxiety and cortisol levels. This was in comparison with individuals who only ate between 6am and 10pm [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25300105/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3 style="text-align: justify;"><span style="font-weight: 400;">Supplements</span></h3> <h4 style="text-align: justify;"><span style="font-weight: 400;">Probiotics</span></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Genetic variants of the </span><em><span style="font-weight: 400;">EFHC2 </span></em><span style="font-weight: 400;">gene may impair calcium levels in the brain, causing an increase in cortisol and anxiety as a result.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The combination of </span><a href="http://content.selfdecode.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium</span></em> <em><span style="font-weight: 400;">longum</span></em></a><span style="font-weight: 400;"> and </span><a href="https://www.selfhacked.com/blog/l-helveticus/"><em><span style="font-weight: 400;">Lactobacillus helveticus</span></em></a> <span style="font-weight: 400;">taken daily for 30 days decreased anxiety, hostility, and levels of the stress-related hormone</span> <a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><em><span style="font-weight: 400;">cortisol</span></em></a><span style="font-weight: 400;"> in healthy volunteers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21983070/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h4 style="text-align: justify;"><span style="font-weight: 400;">Bacopa Monnieri</span></h4> <ul> <li style="font-weight: 400; text-align: justify;"><span style="font-weight: 400;">Supplementation with </span><a href="https://content.selfdecode.com/blog/bacopa-monnieri-4/"><em><span style="font-weight: 400;">Bacopa monnieri</span></em></a> <span style="font-weight: 400;">for 12 weeks reduced anxiety in a preliminary human study [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11498727"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400; text-align: justify;"><em><span style="font-weight: 400;">Bacopa monnieri</span></em><span style="font-weight: 400;"> supplementation also reduced cortisol levels and overall stress in another study [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/23788517"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul>
344 | content_snp_table_3186287353465369_key == 3186287353465369
344 | content_snp_table_3186287353465369_blur == True
344 | content_snp_table_3186287353465369_hidden == False
344 | content_learn_more_5699752804329306_key == 5699752804329306
344 | content_learn_more_5699752804329306_blur == True
344 | content_learn_more_5699752804329306_hidden == False
344 | content_learn_more_5699752804329306_text == Based on the variants we looked at, your EFHC2 gene makes you somewhat more likely to develop anxiety. However, this doesn't necessarily reflect your overall risk; it’s just one gene related to it. Keep scrolling to find out more.
344 | content_recommendation_3093032383548102_key == 3093032383548102
344 | content_recommendation_3093032383548102_blur == True
344 | content_recommendation_3093032383548102_hidden == False
rsIDs = rs1562875,rs5906966
rsStatus = rs1562875,EFHC2,chrX,44325676,A,T,,,15,0,Normal
rsStatus = rs5906966,,chrX,44433972,A,G,,,4,14,HET
