347 | id == 347
347 | category_id == 21
347 | category_order == 18
347 | category_name == Anxiety
347 | category_color == #C47AC0
347 | slug == ESR-anxiety
347 | title == Can Sex Hormones Influence Anxiety? (ESR)
347 | meta_description == ESR1 and ESR2 code for estrogen receptors. Their variants may have differing effects on anxiety. Read more here.
347 | summary == <p style="text-align:justify"><strong>The <em>ESR1</em> and <em>ESR2</em> genes code for estrogen receptors. Variants of these genes may impact the production of protein BDNF. BDNF helps form brain cell connections within a brain region that can regulate stress hormone release. Read more to learn about <em>ESR1</em> and <em>ESR2</em> variants, and about recommendations you can follow to potentially mitigate their effects. &nbsp;</strong></p>
347 | overall_score_text == Your Anxiety Score (based on ESR genes)
347 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ESR-Anxiety.jpg
347 | author_id == 14
347 | author_name == Shany Lahan
347 | author_title == MS (Neuroscience)
347 | author_order == 5
347 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
347 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
347 | reviewer == None
347 | medical_reviewer_id == 11
347 | medical_reviewer_name == Puya Yazdi
347 | medical_reviewer_title == MD
347 | publish_date == 2020
347 | publish_date == 9
347 | publish_date == 23
347 | avg_rating == 5.0
347 | tags_id == 159
347 | tags_name == BDNF
347 | tags_id == 416
347 | tags_name == Cortisol
347 | tags_id == 733
347 | tags_name == ESR1 Gene
347 | tags_id == 734
347 | tags_name == ESR2 Gene
347 | tags_id == 133
347 | tags_name == Estrogen
347 | tags_id == 735
347 | tags_name == Generalized Anxiety Disorder
347 | tags_id == 532
347 | tags_name == Hippocampus
347 | tags_id == 736
347 | tags_name == Phobia
347 | tags_id == 50
347 | tags_name == Stress
347 | tags_id == 57
347 | tags_name == Synaptic Plasticity
347 | permissions_favorite == False
347 | permissions_rate == False
347 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ESR1 </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">ESR2 </span></em><span style="font-weight: 400;">genes code for estrogen receptors. Variants of these genes may influence anxiety by increasing or decreasing production of protein BDNF. BDNF can form brain cell connections within the hippocampus, a brain region that regulates the release of stress-related hormones. Lifestyle and supplement modifications can counteract the effects of some of these variants by increasing production of BDNF.</span></span></p> <h2 style="text-align: justify;"><strong><em>ESR</em> and Anxiety</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="../../../gene/esr1/"><em><span style="font-weight: 400;">ESR1 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> and </span><a href="../../../gene/esr2/"><em><span style="font-weight: 400;">ESR2 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> code for estrogen receptors &alpha; and &beta;, respectively. Upon binding by estrogens, these receptors are able to regulate the production of proteins [</span><a href="https://ghr.nlm.nih.gov/gene/ESR1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ghr.nlm.nih.gov/gene/ESR2"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Estrogens are a group of sex hormones whose levels normally fluctuate in accordance with menstrual cycles of women. While low levels of estrogens have long been linked to mood disturbances and anxiety, administration of estrogens to women with low estrogen levels has been shown to enhance mood and reduce anxiety [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16554740/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=7632640"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=219802"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=8598756"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Estrogen receptors &alpha; and &beta; can be found in abundance in a brain region called the hippocampus, where binding by estrogens can increase production of </span><a href="https://selfhacked.com/blog/a-comprehensive-list-of-natural-ways-to-increase-bdnf/"><span style="font-weight: 400;">BDNF</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16554740/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9518642/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/2329377/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23873366/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">BDNF is a protein important for the expansion and survival of brain cells (neurons) during brain development. BDNF can also strengthen, weaken, and reorganize connections between neurons of the hippocampus, via a process termed </span><a href="https://selfhacked.com/blog/synaptic-plasticity/"><span style="font-weight: 400;">neuroplasticity</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24668475/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In stressful situations, the hippocampus can prevent excess release of </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;"> and other stress-related hormones. In situations of chronic stress, prolonged exposure to elevated levels of cortisol can decrease BDNF levels in the hippocampus and promote abnormal neuronal connections associated with this brain region, thus resulting in dysregulation of cortisol release [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637449/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7891134/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22522470/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Individuals with stress-induced anxiety, as well as individuals with certain anxiety disorders, have been shown to have higher cortisol levels than healthy controls [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637449/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11005547/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">ESR1 </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">ESR2 </span></em><span style="font-weight: 400;">have been associated with anxiety disorders. Specifically, </span><em><span style="font-weight: 400;">ESR1 </span></em><span style="font-weight: 400;">variants have been associated with decreased risk of phobia (characterized by extreme fear of something), while an </span><em><span style="font-weight: 400;">ESR2 </span></em><span style="font-weight: 400;">variant has been associated with increased risk of generalized anxiety disorder (characterized by random, unexplained fear or worry) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21570196"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">It&rsquo;s possible that the protective variants of </span><em><span style="font-weight: 400;">ESR1 </span></em><span style="font-weight: 400;">may produce increased levels of estrogen receptor &alpha;, leading to increased production of BDNF upon binding of estrogen receptor &alpha; by estrogens. This can enhance connectivity of hippocampal cells, regulate stress hormone release, and protect against anxiety disorders, such as phobia [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20850223/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">On the other hand, it&rsquo;s possible that the risk variant of </span><em><span style="font-weight: 400;">ESR2 </span></em><span style="font-weight: 400;">may produce decreased levels of estrogen receptor &beta;, leading to decreased production of BDNF, dysregulation of stress hormone release, and increased risk of anxiety disorders, such as generalized anxiety disorder [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16554740/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your <em>ESR</em> Results for Anxiety</strong></h2> <p style="text-align: justify;">*4334716999911565*</p> <p style="text-align: justify;">*2677483485812721*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>ESR1 </em></strong><a href="../../../snp/rs2234693/"><strong>rs2234693</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of phobia (women)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with phobia</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>ESR1 </em></strong><a href="../../../snp/rs9340799/"><strong>rs9340799</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased risk of phobia (women)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with phobia</span></li> </ul> <p style="text-align: justify;"><strong><em>ESR2 </em></strong><a href="../../../snp/rs1256049/"><strong>rs1256049</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of generalized anxiety disorder (women)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with anxiety</span></li> </ul> <p style="text-align: justify;">*5974554317821958*</p> <p style="text-align: justify;">*9577645726820554*</p> <h2 style="text-align: justify;"><strong>Recommendations for Reducing Anxiety</strong></h2> <p style="text-align: justify;">*8894814370152211*</p> <p style="text-align: justify;"><span style="font-weight: 400;">As protective variants of </span><em><span style="font-weight: 400;">ESR1 </span></em><span style="font-weight: 400;">may increase production of estrogen receptor &alpha;, and risk variants of </span><em><span style="font-weight: 400;">ESR2 </span></em><span style="font-weight: 400;">may decrease production of estrogen receptor &beta;, it might seem logical to try and increase estrogen receptor production in an attempt to mitigate anxiety. However, an increased number of estrogen receptors may result in increased binding of these receptors by estrogens. This may promote the development of breast cancer, or lead to other undesired effects [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16421368/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Individuals carrying risk variants of </span><em><span style="font-weight: 400;">ESR2 </span></em><span style="font-weight: 400;">should therefore focus on increasing production of BDNF instead, which may strengthen connectivity of the hippocampus, regulate the release of stress hormones, and reduce anxiety.</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Exercise</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">There is abundant evidence showing that </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">physical exercise</span></a><span style="font-weight: 400;"> can promote neuroplasticity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17879376/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16298350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20869354/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29959048/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similarly, numerous studies have demonstrated increases in BDNF levels after exercise interventions. In two animal studies, physical exercise was found to increase the amount of BDNF specifically in the hippocampus [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21907264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24120943/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Individuals who regularly take part in physical exercise have been observed to experience lower levels of neuroticism, anxiety, and depression. Conversely, a number of studies have shown that individuals who do not exercise regularly may be at increased risk of anxiety [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26088005/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Aerobic exercise, as opposed to strengthening or stretching exercise, may be most effective at reducing anxiety in both healthy people and those diagnosed with anxiety disorders, such as generalized anxiety, panic disorder, and PTSD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25874370/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11148895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28088704"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise may reduce anxiety by increasing the amount of BDNF in the hippocampus.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Sun Exposure</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The sun is the best source of </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;">.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Lack of sunlight has been shown to decrease the amount of BDNF in the brain, while exposure to sunlight has been shown to increase BDNF in the blood. In a study of rats, vitamin D was observed to increase BDNF specifically in the hippocampus [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20614233"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23133609"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31357443/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, symptoms of anxiety seem to follow a seasonal pattern, with symptoms significantly worsening in dark winters [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695951"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a small trial of individuals with generalized anxiety disorder, those who took vitamin D supplements as an add-on to their conventional medication experienced greater anxiety reduction, in comparison to those that did not take the vitamin D add-on [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31478182/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The sun is the best source of vitamin D. Sunlight may reduce anxiety by increasing the amount of BDNF in the hippocampus.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Yoga</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">Yoga</span></a><span style="font-weight: 400;"> has been shown to reduce stress in a number of studies, and a large body of evidence similarly supports its benefits in regards to anxiety reduction [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24049209"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25558129"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26228429"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19341989"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In individuals with depression, yoga was found to significantly increase levels of BDNF in the blood. This effect was similar to that of a conventional medication [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24049208"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of older adults, an exercise intervention containing a yoga sequence was found to increase blood levels of BDNF. This finding was associated with an increase in hippocampal size, suggesting that BDNF was promoting the formation of new brain cells and brain cell connections in these individuals [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21282661/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Yoga may reduce anxiety by increasing the amount of BDNF in the hippocampus.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Fish Oil (Omega-3)</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Fish oil</span></a><span style="font-weight: 400;"> contains DHA and EPA, two types of omega-3 fatty acids. Low levels of omega-3 fatty acids have been associated with increased levels of social anxiety [</span><a href="https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16243493"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Omega-3 supplementation reduced anxiety symptoms in clinical trials focused on healthy individuals and substance abusers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191260/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275606/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Many studies have shown that fish oil can increase the amount of BDNF in the brain and promote neuroplasticity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31098654/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21720194/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16500747/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30367533/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23872044/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a mouse study, omega-3 was found to increase the amount of BDNF specifically in the hippocampus, promote the development of hippocampal cells, and increase hippocampal size [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18848400/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil (omega-3) supplements may reduce anxiety by increasing the amount of BDNF in the hippocampus.&nbsp;</span></p>
347 | content_snp_table_4334716999911565_key == 4334716999911565
347 | content_snp_table_4334716999911565_blur == True
347 | content_snp_table_4334716999911565_hidden == False
347 | content_snp_table_2677483485812721_key == 2677483485812721
347 | content_snp_table_2677483485812721_blur == True
347 | content_snp_table_2677483485812721_hidden == False
347 | content_learn_more_5974554317821958_key == 5974554317821958
347 | content_learn_more_5974554317821958_blur == True
347 | content_learn_more_5974554317821958_hidden == False
347 | content_learn_more_5974554317821958_text == Based on the variants we looked at, your ESR1 gene is not associated with anxiety. However, other genes and health factors may still contribute to your risk.
347 | content_learn_more_9577645726820554_key == 9577645726820554
347 | content_learn_more_9577645726820554_blur == True
347 | content_learn_more_9577645726820554_hidden == False
347 | content_learn_more_9577645726820554_text == Based on the variants we looked at, your ESR2 gene is not associated with anxiety. However, other genes and health factors may still contribute to your risk.
347 | content_recommendation_8894814370152211_key == 8894814370152211
347 | content_recommendation_8894814370152211_blur == True
347 | content_recommendation_8894814370152211_hidden == False
rsIDs = rs1256049,rs9340799,rs2234693
rsStatus = rs1256049,ESR2,chr14,64257333,C,T,,,31,1,HET
rsStatus = rs9340799,ESR1,chr6,151842246,A,G,,,17,28,HET
rsStatus = rs2234693,ESR1,chr6,151842200,T,C,G,,29,16,HET
