349 | id == 349
349 | category_id == 21
349 | category_order == 18
349 | category_name == Anxiety
349 | category_color == #C47AC0
349 | slug == GABA-receptor-anxiety
349 | title == GABA-A Receptor: Key Player in Anxiety (GABR)
349 | meta_description == Genes encoding different parts of the GABA-A receptor can contribute to stress & anxiety. Click to learn more.
349 | summary == <p style="text-align:justify"><strong>The GABA-A receptor is the central figure in anxiety. Scientists have uncovered two crucial variants in the genes that help make the GABA-A receptor &mdash; learn the details and get gene-based tips to relieve anxiety!&nbsp;</strong></p>
349 | overall_score_text == Your Anxiety Score (Based on GARB Genes)
349 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/GABR-Anxiety.jpg
349 | author_id == 9
349 | author_name == Aleksa Ristic
349 | author_title == MS (Pharmacy)
349 | author_order == 45
349 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
349 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
349 | reviewer == None
349 | medical_reviewer_id == 11
349 | medical_reviewer_name == Puya Yazdi
349 | medical_reviewer_title == MD
349 | publish_date == 2020
349 | publish_date == 9
349 | publish_date == 24
349 | avg_rating == 5.0
349 | tags_id == 112
349 | tags_name == Anxiety
349 | tags_id == 711
349 | tags_name == GABA
349 | tags_id == 740
349 | tags_name == GABRA6 gene
349 | tags_id == 739
349 | tags_name == GABRG2 gene
349 | tags_id == 716
349 | tags_name == Mental Health
349 | tags_id == 50
349 | tags_name == Stress
349 | permissions_favorite == False
349 | permissions_rate == False
349 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>GABA signaling via the GABA-A receptor plays a key role in mental health and anxiety prevention.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Variants in the genes that help make the GABA-A receptor correlate with higher odds of anxiety and impaired stress response.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific lifestyle changes and supplements can prevent and relieve anxiety by targeting your gene variants.</strong></span></p> <h2><strong>GABA Receptor Genes &amp; Anxiety</strong></h2> <p><span style="font-weight: 400;">The GABA-A receptor is the primary target of </span><a href="https://selfhacked.com/blog/natural-ways-to-increase-gaba/"><span style="font-weight: 400;">GABA</span></a><span style="font-weight: 400;"> in the brain. Genes encoding different parts of that receptor, such as </span><a href="https://selfdecode.com/gene/gabra6/"><span style="font-weight: 400;">GABRA6</span></a><span style="font-weight: 400;"> and </span><a href="https://selfdecode.com/gene/gabrg2/"><span style="font-weight: 400;">GABRG2</span></a><span style="font-weight: 400;">, can influence the function of GABA-A receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783721/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Impaired GABA-A receptor activation is the hallmark of</span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"> <span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> disorders, and most treatment options aim at balancing GABA levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12662130/#:~:text=Anxiety%20stems%20from%20and%20perpetuates,of%20the%20excitatory%20neurotransmitter%20glutamate."><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your GABR Results for Anxiety</strong></h2> <p>*3458610233983210*</p> <p><strong>GABRG2 </strong><a href="https://selfdecode.com/snp/rs211037/"><strong>rs211037</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24047446/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with anxiety and impaired </span><a href="https://selfhacked.com/blog/factors-counteract-stress-response/"><span style="font-weight: 400;">stress response</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely impairs GABA function via the GABA-A receptor</span></li> </ul> <p><strong>GABRA6 </strong><a href="https://selfdecode.com/snp/rs3219151/"><strong>rs3219151</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21902679/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15197399/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41598-017-12776-8"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with anxiety and impaired </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> response</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely impairs GABA function via the GABA-A receptor</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">People with this variant may be prone to anxiety after stressful life events</span></li> </ul> <p>*3176344656766887*</p> <p>&nbsp;</p> <h2><strong>Recommendations for Reducing Anxiety</strong></h2> <p>*5551026164535606*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Exercise may help relieve anxiety by boosting</span><a href="https://selfhacked.com/blog/natural-ways-to-increase-gaba/"> <span style="font-weight: 400;">GABA</span></a><span style="font-weight: 400;"> in the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31326567/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501262/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People who</span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"> <span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> regularly experience less neuroticism, anxiety, and</span><a href="https://selfhacked.com/blog/natural-treatments-depression/"> <span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-1843-x"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aerobic exercise and</span><a href="https://selfhacked.com/blog/health-benefits-yoga/"> <span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> may be most effective at reducing stress &amp; anxiety in both healthy people and those with a diagnosed anxiety disorder [</span><a href="http://www.tandfonline.com/doi/full/10.1080/16506073.2015.1028094"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11148895"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28088704"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111147/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="http://journals.sagepub.com/doi/abs/10.2466/pms.109.3.924-930"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19341989"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Regular exercise may help with anxiety by targeting your gene variants.</span></p> <h4><strong>Aromatherapy</strong></h4> <p><span style="font-weight: 400;">Preliminary research in humans shows that aromatherapy may help reduce anxiety and tension [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25234160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different essential oils, especially those of</span><a href="https://selfhacked.com/blog/lavender-health-benefits/"> <span style="font-weight: 400;">lavender</span></a><span style="font-weight: 400;"> and sweet orange, can reduce</span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"> <span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> by activating GABA-A receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/18635155/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/16095639/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/22849536/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099651/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Chamomile</strong></h4> <p><a href="https://content.selfdecode.com/blog/health-benefits-chamomile/"><span style="font-weight: 400;">Chamomile</span></a><span style="font-weight: 400;"> extract may reduce mild-to-moderate anxiety, depression, and stress without causing excessive sedation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600408/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600416/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16628544"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Chamomile owes its anti-anxiety effects to the flavonoid</span><a href="http://selfhacked.com/blog/top-11-science-based-health-benefits-apigenin/"> <span style="font-weight: 400;">apigenin</span></a><span style="font-weight: 400;">, which targets your gene variant by balancing GABA in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11578656"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683737/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19441011"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17143534"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Bacopa</strong></h4> <p><span style="font-weight: 400;">Supplementation with </span><a href="https://content.selfdecode.com/blog/bacopa-monnieri-4/"><em><span style="font-weight: 400;">Bacopa monnieri</span></em></a> <span style="font-weight: 400;">reduced anxiety in three clinical trials. Bacopa&nbsp;also reduced cortisol levels and overall stress in another study [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11498727"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><span style="font-weight: 400;"><a href="https://pubmed.ncbi.nlm.nih.gov/23354535/">R</a>, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/23788517"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The beneficial effects of Bacopa on mental health partly stem from its potential to boost GABA in the brain [<a class="c-link" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/" target="_blank" rel="noopener noreferrer" data-stringify-link="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/" data-sk="tooltip_parent">R</a>, <a class="c-link" href="https://link.springer.com/article/10.1007/s00213-007-1049-8" target="_blank" rel="noopener noreferrer" data-stringify-link="https://link.springer.com/article/10.1007/s00213-007-1049-8" data-sk="tooltip_parent">R</a>, <a class="c-link" href="https://www.ncbi.nlm.nih.gov/pubmed/1921425" target="_blank" rel="noopener noreferrer" data-stringify-link="https://www.ncbi.nlm.nih.gov/pubmed/1921425" data-sk="tooltip_parent">R</a>].</span></p> <p><strong><span style="font-weight: 400;">Note that Bacopa </span><span style="font-weight: 400;">supplements should be taken with a meal to be successfully absorbed by the body.</span></strong></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong><span style="font-weight: 400;">Supplementation with <em>Bacopa monnieri</em> may reduce anxiety by targeting your gene variants.</span></strong></span></p> <h4><strong>Lemon Balm</strong></h4> <p><span style="font-weight: 400;">Folks have traditionally consumed </span><a href="https://content.selfdecode.com/blog/amazing-health-benefits-of-lemon-balm-with-side-effects/"><span style="font-weight: 400;">lemon balm</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Melissa officinalis</span></em><span style="font-weight: 400;">) tea for its calming properties [</span><a href="http://www.sciencedirect.com/science/article/pii/S0023643807001247"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Lemon balm improved anxiety, stress, insomnia &amp; mood multiple clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22207903"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15272110"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12062586"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12888775"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It works by preventing GABA degradation and boosting GABA-A receptor activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245564/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230760/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Lemon balm may reduce the impact of your variants and relieve stress &amp; anxiety.</span></p>
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349 | content_learn_more_3176344656766887_text == Based on the variants we looked at, your GABR genes are associated with slightly higher odds of anxiety. However, this doesn't necessarily reflect your overall risk of anxiety, just one gene related to it. Regular exercise, chamomile, and other natural remedies may improve anxiety symptoms by targeting your gene variants. Keep reading to learn more.
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rsIDs = rs3219151,rs211037
rsStatus = rs3219151,GABRA6,chr5,161701908,C,A,T,,18,0,Normal
rsStatus = rs211037,GABRG2,chr5,162101274,C,G,T,,18,0,Normal
