354 | id == 354
354 | category_id == 21
354 | category_order == 18
354 | category_name == Anxiety
354 | category_color == #C47AC0
354 | slug == TENM4-social-anxiety
354 | title == A Key Player in Mental Health & Anxiety (TENM4)
354 | meta_description == The TENM4 gene influences your brain's response to stress and fear. Learn about its link with anxiety.
354 | summary == <p style="text-align:justify"><strong>Did you know that genes can influence your response to stress and fear? Read this post to learn how the TENM4 gene impacts mental health and anxiety.</strong></p>
354 | overall_score_text == Your Anxiety Score (Based on TENM4 Gene)
354 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TENM4-Anxiety.jpg
354 | author_id == 9
354 | author_name == Aleksa Ristic
354 | author_title == MS (Pharmacy)
354 | author_order == 45
354 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
354 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
354 | reviewer == None
354 | medical_reviewer_id == 11
354 | medical_reviewer_name == Puya Yazdi
354 | medical_reviewer_title == MD
354 | publish_date == 2020
354 | publish_date == 10
354 | publish_date == 2
354 | avg_rating == 5.0
354 | tags_id == 742
354 | tags_name == Amygdala
354 | tags_id == 112
354 | tags_name == Anxiety
354 | tags_id == 716
354 | tags_name == Mental Health
354 | tags_id == 26
354 | tags_name == Neurogenesis
354 | tags_id == 50
354 | tags_name == Stress
354 | tags_id == 743
354 | tags_name == TENM4 gene
354 | permissions_favorite == False
354 | permissions_rate == False
354 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The TENM4 gene influences the response of your brain to stress and fear. Changes in its function may contribute to different mental health disorders.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>One TENM4 variant correlates with higher odds of a social anxiety disorder.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific lifestyle interventions and supplements can reduce anxiety by targeting your TENM4 gene.</strong></span></p> <h2><strong>The TENM4 Gene &amp; Anxiety</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/tenm4/"><span style="font-weight: 400;">TENM4</span></a><span style="font-weight: 400;"> gene, also known as ODZ4, ensures proper nerve communication and development in the brain [</span><a href="https://ghr.nlm.nih.gov/gene/TENM4"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360184/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Mutations in this gene impact the amygdala function, the part of the brain responsible for stress and fear processing. These mutations have been associated with anxiety and other mental health disorders [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23611537/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403662/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your TENM4 Results for Anxiety</strong></h2> <p>*3693661659265699*</p> <p><strong>TENM4</strong> <a href="../../../snp/rs12576775/"><strong>rs12576775</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28272115"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively higher odds of a social anxiety disorder</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &ldquo;G&rdquo; allele may amplify stress response in the amygdala [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23611537/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">People with this variant may be more prone to other psychiatric conditions, such as a bipolar disorder [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*1189284690537630*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Anxiety</strong></h2> <p>*6592925838452368*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Cognitive-Behavioral Therapy</strong></h4> <p><span style="font-weight: 400;">Cognitive-behavioral therapy can help with anxiety by fixing nerve connections in the brain and reducing amygdala activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872422/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It has well-documented benefits for social anxiety and other anxiety disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25932596"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different forms of behavioral therapy, such as in-person, internet-based, and self-guided, are a part of standard care for anxiety &mdash; consult with a healthcare professional about your options [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913603/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19880935"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cognitive-behavioral therapy may reduce anxiety by targeting your gene variant.</span></p> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Regular exercise boosts nerve growth and development and reduces amygdala reactivity to fear [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805662/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138282/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930267/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">People who </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> regularly experience less neuroticism, anxiety, and depression, all of which correlate with your TENM4 variant [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-1843-x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aerobic exercise may be most effective at reducing anxiety in both healthy people and those diagnosed with an anxiety disorder [</span><a href="http://www.tandfonline.com/doi/full/10.1080/16506073.2015.1028094"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11148895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28088704"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Regular exercise will reduce the impact of your TENM4 variant on anxiety and overall mental health.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>CBD Oil</strong></h4> <p><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;">, the active ingredient in cannabis and hemp, is one of the most potent </span><a href="https://selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/"><span style="font-weight: 400;">cannabinoids</span></a><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">CBD reduced anxiety from stressful situations such as public speaking and medical procedures in several trials on healthy people [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14583744"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22290374"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425583/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30328956"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to preliminary evidence, it may help with various anxiety disorders, including social anxiety and panic disorders </span><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/6285406"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31866386/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856203/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Activation of </span><a href="https://selfhack.com/blog/the-lectin-sensitive-gene-cannabanoid-receptor-1-genes-cnr1-rs1049353/"><span style="font-weight: 400;">cannabinoid receptors</span></a><span style="font-weight: 400;"> reduces amygdala reactivity to stress, which is one of the primary mechanisms behind the anti-anxiety effects of CBD [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817535/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Note that CBD oil is derived from </span><a href="https://selfhacked.com/blog/top-6-unique-super-effective-ways-counteract-negative-performance-effects-cannabismarijuana/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">cannabis</span></a><span style="font-weight: 400;">, which is a controlled substance in many countries and states. Therefore, make sure to verify the legality of CBD products where you live before seeking them out.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CBD oil may relieve anxiety by blocking the effects of your gene variant.</span></p>
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354 | content_learn_more_1189284690537630_text == Based on the variant we looked at, your TENM4 gene is associated with slightly higher odds of social anxiety. However, this doesn't necessarily reflect your overall risk of anxiety, just one gene related to it. Regular exercise may improve anxiety symptoms by targeting your gene variant. Keep reading to learn more.
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rsIDs = rs12576775,rs1049353
rsStatus = rs12576775,TENM4,chr11,79366149,A,C,G,,31,0,Normal
rsStatus = rs1049353,CNR1,chr6,88143916,C,A,T,,41,1,HET
