360 | id == 360
360 | category_id == 21
360 | category_order == 18
360 | category_name == Anxiety
360 | category_color == #C47AC0
360 | slug == nos1-nos1ap-stress-resilience
360 | title == How Do These Nitric Oxide Genes Affect Stress Resilience? (NOS1 and NOS1AP)
360 | meta_description == Variants of NOS1 and NOS1AP are associated with anxiety and stress resilience. Click for some diet and gene-based tips!
360 | summary == <p style="text-align:justify"><strong>The two related genes NOS1 and NOS1AP both affect nitric oxide production. Variants can cause your brain to become overactive. How does this happen and what can we do about it?</strong></p>
360 | overall_score_text == Your Stress Resilience Score (based on NOS1 and NOS1AP genes)
360 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NOS1-Anxiety_1.jpg
360 | author_id == 15
360 | author_name == John Williams
360 | author_title == B.Sc
360 | author_order == 3987
360 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/sinan_pic.png
360 | author_intro == <p>John received his BSc from the University of Toronto.&nbsp;John has spent the last several years teaching high school science and math to English-language learners, which has forced him to learn how to simplify difficult concepts as much as possible. He has also worked in two different research labs and has experience as a student intern working and studying under doctors in hospitals and clinics to help diagnose and treat patients, interpret lab results and fill out mountains of paperwork.</p>
360 | reviewer == None
360 | medical_reviewer_id == 11
360 | medical_reviewer_name == Puya Yazdi
360 | medical_reviewer_title == MD
360 | publish_date == 2020
360 | publish_date == 9
360 | publish_date == 29
360 | avg_rating == 5.0
360 | tags_id == 112
360 | tags_name == Anxiety
360 | tags_id == 556
360 | tags_name == Nitric Oxide
360 | tags_id == 751
360 | tags_name == NOS1AP Gene
360 | tags_id == 406
360 | tags_name == NOS1 gene
360 | tags_id == 752
360 | tags_name == Resilience
360 | tags_id == 50
360 | tags_name == Stress
360 | permissions_favorite == False
360 | permissions_rate == False
360 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">NOS1 </span></em><span style="font-weight: 400;">encodes nitric oxide synthase 1 and is responsible for making nitric oxide. </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> encodes its adaptor protein which interacts with NOS1 to change its effectiveness. Variants that produce more nitric oxide are associated with anxiety since nitric oxide increases glutamate and decreases GABA levels in the brain. Lifestyle, diet, and supplement modifications can counteract the effects of these variants by increasing GABA or by decreasing glutamate.</span></span></p> <h2 style="text-align: justify;"><strong><em>NOS1 </em>and <em>NOS1AP</em> and Stress Resilience/Anxiety</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">Anxiety can be thought of as an impaired ability in dealing with stress. Those that have higher stress resilience are generally less affected by stressful events both physically and mentally. As a result, this post will include SNPs with variants connected to stress, anxiety and general resilience [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181630/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">NOS1</span></em><span style="font-weight: 400;"> gene encodes nitric oxide synthase 1, a protein responsible for making the gas nitric oxide (NO). The </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> gene encodes the adaptor protein for NOS1; it appears to interact with NOS1 and change its effectiveness. The exact relationship between NOS1AP and NOS1 is not clear as scientists have found conflicting results </span><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/29625171/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28465168/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">When </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> protein attaches to the </span><em><span style="font-weight: 400;">NOS1</span></em><span style="font-weight: 400;"> protein, it causes anxiety levels to increase. Variants that produce more nitric oxide are associated with anxiety because nitric oxide increases levels of glutamate and decreases levels of GABA. Since glutamate &lsquo;excites&rsquo; your brain while GABA does the opposite, this causes an overactive brain and can lead to anxiety [</span><a href="https://www.nature.com/articles/nm.3644"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15341192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your <em>NOS1</em> and <em>NOS1AP</em> Results for Stress Resilience</strong></h2> <p style="text-align: justify;">*8226748926304348*</p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>NOS1AP </em></strong><a href="https://selfdecode.com/snp/rs111479527/"><strong>rs111479527</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with increased risk of anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = not associated with anxiety</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs: </strong></p> <p style="text-align: justify;"><strong><em>NOS1AP </em></strong><a href="https://selfdecode.com/snp/rs164148/"><strong>rs164148</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with increased stress levels&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = not associated with stress</span></li> </ul> <p style="text-align: justify;"><strong><em>NOS1AP </em></strong><a href="https://selfdecode.com/snp/rs4657178/"><strong>rs4657178</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/28465168/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with increased resilience when faced with problems&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with resilience</span></li> </ul> <p style="text-align: justify;"><strong><em>NOS1AP </em></strong><a href="https://selfdecode.com/snp/rs17460657/"><strong>rs17460657</strong></a><strong>&nbsp;</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with lower resilience when faced with problems&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with resilience</span></li> </ul> <p style="text-align: justify;"><strong><em>NOS1 </em></strong><a href="https://selfdecode.com/snp/rs7295972/"><strong>rs7295972</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with increased stress levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = not associated with stress</span></li> </ul> <p style="text-align: justify;"><strong><em>NOS1 </em></strong><a href="https://selfdecode.com/snp/rs10744891/"><strong>rs10744891</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with lower resilience when faced with problems</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with resilience</span></li> </ul> <p style="text-align: justify;">*6866566828827252*</p> <h2 style="text-align: justify;"><strong>Recommendations for Improving Anxiety/Stress Resilience</strong></h2> <p style="text-align: justify;"><strong>*4617316039549048*</strong></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Yoga</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Individuals who performed </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> for a 12 week period were found to have higher levels of GABA in the brain and reduced anxiety. Since GABA is the chemical in your brain responsible for making your brain less active and excitable, this suggests that performing yoga on a regular basis may be able to help with anxiety and stress [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26228429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Performing yoga on a regular basis may help with anxiety by increasing GABA levels.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Magnesium</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Some studies have shown that low </span><a href="https://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">magnesium</span></a><span style="font-weight: 400;"> levels are associated with your brain being too 'excited'. One study showed that magnesium levels were generally lower in anxious patients. Some </span><em><span style="font-weight: 400;">NOS1</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> variants produce more nitric oxide, which results in less GABA (makes your brain less active) and more glutamate (makes your brain more active) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28465168/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Magnesium is known to block the NMDA receptor -- this is the receptor that glutamate needs to bind to do its job. Since glutamate can't bind when magnesium is there, your brain generally becomes less hyperactive and you are hopefully able to relax as a result [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK507254/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Magnesium can be taken as a supplement or added to your diet. Good sources of magnesium in your diet include nuts and leafy, green vegetables, with spinach providing a particularly high amount</span> <a href="https://my.clevelandclinic.org/health/articles/15650-magnesium-rich-food"><span style="font-weight: 400;">[R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Consider eating more nuts and leafy, green vegetables; the magnesium boost may help with anxiety.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Lavender oil</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/lavender-health-benefits/"><span style="font-weight: 400;">Lavender oil</span></a><span style="font-weight: 400;"> consists of a number of chemicals obtained from the lavender family of plants. </span><span style="font-weight: 400;">Supplementing with lavender oil has been found to improve anxiety, depression, restlessness and sleep disturbances [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22475718/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Increased nitric oxide levels are associated with anxiety because nitric oxide reduces the amount of GABA. Since lavender oil seems to help with anxiety by increasing GABA levels in the brain, </span><em><span style="font-weight: 400;">NOS1/NOS1AP</span></em><span style="font-weight: 400;"> variants that make extra nitric oxide may benefit from supplementing [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplementing with lavender oil may help with symptoms of anxiety.</span></p>
360 | content_snp_table_8226748926304348_key == 8226748926304348
360 | content_snp_table_8226748926304348_blur == True
360 | content_snp_table_8226748926304348_hidden == False
360 | content_learn_more_6866566828827252_key == 6866566828827252
360 | content_learn_more_6866566828827252_blur == True
360 | content_learn_more_6866566828827252_hidden == False
360 | content_learn_more_6866566828827252_text == Based on the variants we looked at, your NOS1AP/NOS1 genes make you somewhat more likely to develop anxiety and/or have impaired stress resilience. However, this doesn't necessarily reflect your overall risk; just two genes related to it. Yoga, lavender oil, and increasing dietary magnesium may help. Keep scrolling to find out more.
360 | content_recommendation_4617316039549048_key == 4617316039549048
360 | content_recommendation_4617316039549048_blur == True
360 | content_recommendation_4617316039549048_hidden == False
rsIDs = rs164148,rs10744891,rs4657178,rs111479527,rs17460657,rs7295972
rsStatus = rs164148,NOS1AP,chr1,162368695,A,C,G,T,37,0,Normal
rsStatus = rs10744891,NOS1,chr12,117284536,G,C,T,,37,0,Normal
rsStatus = rs4657178,NOS1AP,chr1,162240820,C,A,G,T,35,0,Normal
rsStatus = rs111479527,NOS1AP,chr1,162209192,A,G,,,38,0,Normal
rsStatus = rs17460657,NOS1AP,chr1,162292036,A,C,,,26,0,Normal
rsStatus = rs7295972,NOS1,chr12,117309563,A,G,T,,27,0,Normal
