361 | id == 361
361 | category_id == 22
361 | category_order == 19
361 | category_name == Trauma
361 | category_color == #C47AC0
361 | slug == CRHR1-stress-PTSD
361 | title == A Gene That Links Stress With PTSD (CRHR1)
361 | meta_description == The CRHR1 gene plays a crucial role in stress response. Learn about its link with PTSD.
361 | summary == <p style="text-align:justify"><strong>Genes play a crucial role in stress response and related disorders. Read this post to learn about the link between the CRHR1 gene and PTSD.</strong></p>
361 | overall_score_text == Your PTSD Score (Based on CRHR1 Gene)
361 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CRHR-PTSD.jpg
361 | author_id == 9
361 | author_name == Aleksa Ristic
361 | author_title == MS (Pharmacy)
361 | author_order == 45
361 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
361 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
361 | reviewer == None
361 | medical_reviewer_id == 11
361 | medical_reviewer_name == Puya Yazdi
361 | medical_reviewer_title == MD
361 | publish_date == 2020
361 | publish_date == 9
361 | publish_date == 29
361 | avg_rating == 5.0
361 | tags_id == 417
361 | tags_name == CRH
361 | tags_id == 418
361 | tags_name == CRHR1 gene
361 | tags_id == 415
361 | tags_name == HPA axis
361 | tags_id == 6
361 | tags_name == PTSD
361 | tags_id == 50
361 | tags_name == Stress
361 | permissions_favorite == False
361 | permissions_rate == False
361 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The CRHR1 receptor is usually overactive in stress-related disorders such as PTSD.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific </strong><strong><em>CRHR1</em></strong><strong> gene variants have been associated with higher PTSD rates and severity.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Our personalized recommendations can help with PTSD by targeting your </strong><strong><em>CRHR1</em></strong><strong> variants.</strong></span></p> <h2><strong>The Role of CRHR1 in PTSD</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/crhr1/"><span style="font-weight: 400;">CRHR1</span></a><span style="font-weight: 400;"> gene encodes a receptor for </span><a href="http://selfhacked.com/blog/why-your-health-problems-worsen-after-stress-the-role-of-crh/"><span style="font-weight: 400;">CRH</span></a><span style="font-weight: 400;">, the first hormone of the </span><a href="http://selfhacked.com/blog/reasons-cortisol-low-high/"><span style="font-weight: 400;">HPA axis</span></a><span style="font-weight: 400;">. Stress activates the HPA axis, resulting in </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;"> release. Hence, CRH receptors play a significant role in </span><a href="https://selfhacked.com/blog/factors-counteract-stress-response/"><span style="font-weight: 400;">stress response</span></a><span style="font-weight: 400;"> and related disorders [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1394"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31655035/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">CRH release causes fear and </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> via the CRHR1 receptor [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10448190/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12973355/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">People with </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;"> tend to have excess CRH activity and dysfunctional HPA axis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11337099/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175503/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CRH activity via the CRHR1 receptor plays a crucial role in stress-related disorders such as PTSD.</span></p> <p>&nbsp;</p> <h2><strong>Your CRHR1 Results for PTSD</strong></h2> <p>*3383884005456528*</p> <p><strong>Primary SNP:</strong></p> <p><a href="../../../snp/rs12938031/"><strong>rs12938031</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182958/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with relatively higher odds and severity of PTSD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with lower odds and severity of PTSD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &ldquo;G&rdquo; allele likely reduces CRH activity and balances the HPA axis</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><a href="../../../snp/rs4792887/"><strong>rs4792887</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182958/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with lower PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &ldquo;T&rdquo; allele likely reduces CRH activity and balances the HPA axis</span></li> </ul> <p><a href="../../../snp/rs12944712/"><strong>rs12944712</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722863/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = not associated with PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &ldquo;G&rdquo; allele likely increases CRH activity and contributes to HPA dysfunction</span></li> </ul> <p><a href="../../../snp/rs17689882/"><strong>rs17689882</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22748421/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with depression due to a childhood trauma</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with a response to childhood trauma</span></li> </ul> <p>*6658577384496489*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve PTSD</strong></h2> <p>*8775618510671084*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Cognitive-Behavioral Therapy</strong></h4> <p><span style="font-weight: 400;">Cognitive-behavioral therapy can reduce stress and help balance the HPA axis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30917336/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It can improve stress-related disorders such as PTSD, alone or in combination with standard treatment [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26439674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different therapy forms, such as cognitive processing therapy and narrative exposure therapy, are a part of standard care for PTSD&mdash; consult with a healthcare professional about your options [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345529/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cognitive-behavioral therapy can help with PTSD by targeting your gene variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Omega-3</strong></h4> <p><span style="font-weight: 400;">Omega-3 fatty acids from </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> (EPA and DHA) may balance the HPA axis and reduce CRH levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12909818/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23208960/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One study associated PTSD with low blood DHA levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27567082/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Conversely, high blood levels of EPA from omega-3 supplementation correlated with reduced PTSD severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27552592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Omega-3 supplementation prevented </span><a href="https://www.selfhacked.com/blog/resting-heart-rate/"><span style="font-weight: 400;">heart rate</span></a><span style="font-weight: 400;"> spikes in accident survivors with PTSD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27287561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Omega-3 supplements may reduce the impact of your CRHR1 variants on stress &amp; PTSD.</span></p>
361 | content_snp_table_3383884005456528_key == 3383884005456528
361 | content_snp_table_3383884005456528_blur == True
361 | content_snp_table_3383884005456528_hidden == False
361 | content_learn_more_6658577384496489_key == 6658577384496489
361 | content_learn_more_6658577384496489_blur == True
361 | content_learn_more_6658577384496489_hidden == False
361 | content_learn_more_6658577384496489_text == Based on the variants we looked at, your CRHR1 gene is associated with average or slightly higher rates and severity of PTSD. However, this doesn't necessarily reflect your overall risk of PTSD, just one gene related to it. Omega-3 supplementation may improve PTSD symptoms by targeting your gene variants. Keep reading to learn more.
361 | content_recommendation_8775618510671084_key == 8775618510671084
361 | content_recommendation_8775618510671084_blur == True
361 | content_recommendation_8775618510671084_hidden == False
rsIDs = rs17689882,rs4792887,rs12944712,rs12938031
rsStatus = rs17689882,CRHR1,chr17,45829462,G,A,,,14,0,Normal
rsStatus = rs4792887,CRHR1,chr17,45799654,C,T,,,9,0,Normal
rsStatus = rs12944712,CRHR1,chr17,45793781,G,A,,,14,0,Normal
rsStatus = rs12938031,LINC02210-CRHR1,chr17,45777136,A,G,,,17,0,Normal
