362 | id == 362
362 | category_id == 22
362 | category_order == 19
362 | category_name == Trauma
362 | category_color == #C47AC0
362 | slug == CRHR2-stress-PTSD
362 | title == Can This Gene Protect You From PTSD? (CRHR2)
362 | meta_description == The CRHR2 gene reduces stress response. Click to learn how it impacts PTSD rates & severity.
362 | summary == <p style="text-align:justify"><strong>One hormone can have opposite effects on stress, depending on the receptors and their genes. Read this post to learn how the CRHR2 gene impacts PTSD risk &amp; severity.</strong></p>
362 | overall_score_text == Your PTSD Score (Based on CRHR2 Gene)
362 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CRHR2-PTSD.jpg
362 | author_id == 9
362 | author_name == Aleksa Ristic
362 | author_title == MS (Pharmacy)
362 | author_order == 45
362 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
362 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
362 | reviewer == None
362 | medical_reviewer_id == 11
362 | medical_reviewer_name == Puya Yazdi
362 | medical_reviewer_title == MD
362 | publish_date == 2020
362 | publish_date == 9
362 | publish_date == 29
362 | avg_rating == 5.0
362 | tags_id == 416
362 | tags_name == Cortisol
362 | tags_id == 417
362 | tags_name == CRH
362 | tags_id == 755
362 | tags_name == CRHR2 gene
362 | tags_id == 415
362 | tags_name == HPA axis
362 | tags_id == 6
362 | tags_name == PTSD
362 | tags_id == 50
362 | tags_name == Stress
362 | permissions_favorite == False
362 | permissions_rate == False
362 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The CRHR2 gene codes for a receptor that balances stress response and helps reduce anxiety. People with PTSD may have reduced CRHR2 activity.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific gene variants can change CRHR2 activity and influence PTSD risk &amp; severity.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>There&rsquo;s a simple way to prevent and improve PTSD by addressing your CRHR2 gene.</strong></span></p> <h2><strong>The CRHR2 Gene in Stress Response &amp; PTSD</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/crhr2/"><span style="font-weight: 400;">CRHR2</span></a><span style="font-weight: 400;"> gene encodes a receptor for </span><a href="http://selfhacked.com/blog/why-your-health-problems-worsen-after-stress-the-role-of-crh/"><span style="font-weight: 400;">CRH</span></a><span style="font-weight: 400;">, the first hormone of the </span><a href="http://selfhacked.com/blog/reasons-cortisol-low-high/"><span style="font-weight: 400;">HPA axis</span></a><span style="font-weight: 400;">. Stress activates the HPA axis, resulting in </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;"> release [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1395"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31655035/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">CRH receptors play a significant role in </span><a href="https://selfhacked.com/blog/factors-counteract-stress-response/"><span style="font-weight: 400;">stress response</span></a><span style="font-weight: 400;"> and related disorders. Contrary to </span><a href="../../article/crhr1-stress-ptsd-361/"><span style="font-weight: 400;">CRHR1</span></a><span style="font-weight: 400;">, the activation of CRHR2 receptors reduces anxiety, arousal, and depression [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9854171/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15919381/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10742108/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with stress-related conditions such as </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;"> tend to have excess CRHR1 and lower CRHR2 activity, resulting in HPA axis dysfunction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11337099/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175503/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The CRHR2 receptor counteracts CRHR1 and reduces stress &amp; anxiety. People with PTSD may have lower CRHR2 activity.</span></p> <h2><strong>Your CRHR2 Results for PTSD</strong></h2> <p>*8978397017324711*</p> <p><a href="../../../snp/rs2267715/"><strong>rs2267715</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31655035/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with relatively higher PTSD rates &amp; severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with lower PTSD rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely reduces CRHR2 activity</span></li> </ul> <p><a href="../../../snp/rs2190242/"><strong>rs2190242</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">A&rsquo; - associated with relatively higher PTSD rates &amp; severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with lower PTSD rates &amp; severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely increases CRHR2 activity</span></li> </ul> <p>*4561094359409048*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve PTSD</strong></h2> <p>*8654824274563078*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Regular </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> may reduce stress and balance the HPA axis by increasing CRHR2 activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26182188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013452/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People who exercise regularly experience lower levels of neuroticism, anxiety, and </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-1843-x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Both aerobic exercise and resistance training improved PTSD in multiple trials. While aerobic exercise was more effective at improving general anxiety, resistance training helped with specific PTSD symptoms and </span><a href="https://selfhacked.com/blog/sleep-neurophysiology/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> quality [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29049901/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29076530/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29145076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15869081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24911173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25443996/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31743507/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Strenuous exercise increases the blood levels of </span><a href="https://selfhacked.com/blog/npy/"><span style="font-weight: 400;">NPY</span></a><span style="font-weight: 400;">, a molecule that helps prevent PTSD caused by </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> hormones such as CRH and cortisol [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10807963"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10818263"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Aerobic exercise and resistance training may prevent and improve PTSD by targeting your gene variants.</span></p>
362 | content_snp_table_8978397017324711_key == 8978397017324711
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362 | content_learn_more_4561094359409048_text == Based on the variants we looked at, your CRHR2 gene is associated with average or slightly higher rates and severity of PTSD. However, this doesn't necessarily reflect your overall risk of PTSD, just one gene related to it. Regular exercise can prevent and improve PTSD by targeting your gene variants. Keep reading to learn more.
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rsIDs = rs2267715,rs2190242
rsStatus = rs2267715,CRHR2,chr7,30676471,G,A,C,,13,18,HET
rsStatus = rs2190242,CRHR2,chr7,30669859,C,A,G,,31,17,HET
