364 | id == 364
364 | category_id == 22
364 | category_order == 19
364 | category_name == Trauma
364 | category_color == #C47AC0
364 | slug == IL1B-PTSD
364 | title == Can Brain Inflammation Influence PTSD? (IL1B)
364 | meta_description == IL-1b can promote inflammation. Variants of IL1B have been associated with PTSD. Read more here.
364 | summary == <p style="text-align:justify"><strong>IL-1b&nbsp;is a protein that can promote inflammation in response to both infection and psychological stressors. Variants of <em>IL1B </em>have been associated with PTSD. Read to learn more about this association, and to learn about recommendations you may follow to mitigate the negative effects of these variants.</strong><br />  &nbsp;</p>
364 | overall_score_text == Your PTSD Score (based on IL1B gene)
364 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL1b-PTSD.jpg
364 | author_id == 14
364 | author_name == Shany Lahan
364 | author_title == MS (Neuroscience)
364 | author_order == 5
364 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
364 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
364 | reviewer == None
364 | medical_reviewer_id == 11
364 | medical_reviewer_name == Puya Yazdi
364 | medical_reviewer_title == MD
364 | publish_date == 2020
364 | publish_date == 9
364 | publish_date == 29
364 | avg_rating == 5.0
364 | tags_id == 741
364 | tags_name == Fear
364 | tags_id == 463
364 | tags_name == IL-1b
364 | tags_id == 464
364 | tags_name == IL1B gene
364 | tags_id == 24
364 | tags_name == Inflammation
364 | tags_id == 50
364 | tags_name == Stress
364 | tags_id == 756
364 | tags_name == Trauma
364 | permissions_favorite == False
364 | permissions_rate == False
364 | content_article == <p>&nbsp;</p> <table style="width: 80%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 873.435px; text-align: justify;"><strong>Note:</strong>&nbsp;The&nbsp;<em>IL1B</em>&nbsp;gene is mentioned in SelfDecode's <a href="https://get.selfdecode.com/gene-reports/inflammation/" target="_blank" rel="noopener"><strong><em>Inflammation</em></strong></a>&nbsp;and&nbsp;<a href="https://get.selfdecode.com/gene-reports/cardiovascular/" target="_blank" rel="noopener"><strong><em>Cardiovascular</em></strong></a><em>&nbsp;DNA</em><em> Wellness</em><em> Reports</em>. If you&rsquo;re curious to learn more about how your genetics could be impacting each of these aspects of your health, we recommend checking them out!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">IL1B </span></em><span style="font-weight: 400;">may play a role in PTSD by stimulating the excess release of IL-1b, a protein that can promote inflammation. Diet and supplement modifications may counteract the effects of these variants by lowering levels of IL-1b.</span></span></p> <h2 style="text-align: justify;"><strong><em>IL1B</em>&nbsp;and PTSD</strong></h2> <p style="text-align: justify;"><a href="https://selfhack.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1b</span></a><span style="font-weight: 400;"> is a protein (cytokine) released by cells of the immune system [</span><a href="https://ghr.nlm.nih.gov/gene/IL1B"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although the release of IL-1b normally increases in response to infection, its release can also increase after exposure to psychological stressors. For example, researchers studying the effects of childhood trauma on healthy adults found a significant link between childhood trauma and increased blood levels of IL-1b [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16647243/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21745542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23415658/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28599834/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Not surprisingly, IL-1b also plays a major role in the development of mental disorders, such as </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;">. Individuals with PTSD often experience symptoms of stress and anxiety in response to events that elicit traumatic, fear-based memories [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26544749/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In PTSD, continuous exposure to elevated levels of IL-1b has been suggested to inhibit the growth of new brain cells (neurons) in a number of brain regions implicated in fear processing. This could alter the activity of these brain regions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26544749/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22840760/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of the </span><a href="https://selfdecode.com/gene/il1b/"><em><span style="font-weight: 400;">IL1B</span></em></a> gene <span style="font-weight: 400;">have been linked to an increased risk of PTSD and its associated symptoms. These variants may stimulate the excess release of IL-1b in regions of the brain associated with PTSD, which could inhibit the growth of neurons in these brain regions and result in abnormal responses to fear-based memories [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26891860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28681202/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1353022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your <em>IL1B</em> Results for PTSD</strong></h2> <p style="text-align: justify;">*8682807606779284*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>IL1B</em></strong>&nbsp;<a href="https://selfdecode.com/snp/rs16944/"><strong>rs16944</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of depressive &amp; anxiety symptoms in PTSD, relative to &lsquo;G&rsquo; allele</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased risk of depressive &amp; anxiety symptoms in PTSD, relative to &lsquo;A&rsquo; allele</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>IL1B</em></strong>&nbsp;<a href="https://selfdecode.com/snp/rs1143643/"><strong>rs1143643</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of depressive symptoms in PTSD, relative to &lsquo;T&rsquo; allele</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Decreased risk of depressive symptoms in PTSD, relative to &lsquo;C&rsquo; allele</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1B</em></strong>&nbsp;<a href="https://selfdecode.com/snp/rs1143633/"><strong>rs1143633</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of PTSD, relative to &lsquo;C&rsquo; allele</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of PTSD, relative to &lsquo;T&rsquo; allele</span></li> </ul> <p style="text-align: justify;">*5889581431303759*</p> <h2 style="text-align: left;"><strong>Recommendations for Reducing Symptoms of PTSD</strong></h2> <p style="text-align: justify;">*2166800616816957*</p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Fish Oil (Omega-3)</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Fish oil</span></a><span style="font-weight: 400;"> contains DHA and EPA, two types of omega-3 fatty acids [</span><a href="https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Low levels of DHA have been associated with PTSD. Conversely, supplementation of omega-3 and consequent high levels of EPA have been associated with reduced severity of PTSD symptoms after traumatic injury [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27567082/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27552592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a randomized controlled trial of patients with non-healing and inflamed leg wounds, omega-3 supplements significantly lowered blood levels of IL-1b. Similar results were found after omega-3 supplementation, in a clinical trial of rheumatoid arthritis patients [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29735019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/1458789/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil (omega-3) may reduce severity of PTSD symptoms by lowering blood levels of IL-1b.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Cannabidiol (CBD) Oil</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cannabidiol (</span><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;">) is the active ingredient of cannabis and hemp.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementation with CBD oil was found to reduce anxiety, one of the primary symptoms of PTSD, in multiple human studies. Repeated administration of CBD similarly prevented long-term anxiety in a rat model of PTSD (rats subjected to interactions with a predator) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/6285406"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/31866386/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856203/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482919/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/"><span style="font-weight: 400;">R</span></a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Cannabidiol+blocks+long-lasting+behavioral+consequences+of+predator+threat+stress"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In animal- and cell-based studies, CBD was shown to suppress IL-1b production and activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/17592514/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177247/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Note that cannabis may be a controlled substance in your region. Therefore, make sure to verify the legality of CBD products where you live before seeking them out.</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CBD oil may improve symptoms of PTSD by suppressing the production and activity of IL-1b. </span></p>
364 | content_snp_table_8682807606779284_key == 8682807606779284
364 | content_snp_table_8682807606779284_blur == True
364 | content_snp_table_8682807606779284_hidden == False
364 | content_learn_more_5889581431303759_key == 5889581431303759
364 | content_learn_more_5889581431303759_blur == True
364 | content_learn_more_5889581431303759_hidden == False
364 | content_learn_more_5889581431303759_text == Based on the variants we looked at, your IL1B gene makes you somewhat more likely to develop PTSD and its associated symptoms. However, this doesn't necessarily reflect your overall risk of PTSD; it’s just one gene related to it. Supplementation with fish oil (omega-3) and cannabidiol (CBD) oil may help. Keep scrolling to find out more.
364 | content_recommendation_2166800616816957_key == 2166800616816957
364 | content_recommendation_2166800616816957_blur == True
364 | content_recommendation_2166800616816957_hidden == False
rsIDs = rs1143643,rs1143633,rs16944
rsStatus = rs1143643,IL1B,chr2,112830725,C,A,T,,30,0,Normal
rsStatus = rs1143633,IL1B,chr2,112832890,C,A,G,T,40,0,Normal
rsStatus = rs16944,IL1B,chr2,112837290,A,G,,,28,11,HET
