367 | id == 367
367 | category_id == 22
367 | category_order == 19
367 | category_name == Trauma
367 | category_color == #C47AC0
367 | slug == FKBP5-stress-PTSD
367 | title == The Role of Stress Response in PTSD (FKBP5)
367 | meta_description == The FKBP5 gene controls the stress response. Click to learn about its link with PTSD.
367 | summary == <p style="text-align:justify"><strong>Did you know that genes can determine how well someone handles stress and trauma? This post reveals a crucial role of one gene, FKBP5, in stress response and PTSD.</strong></p>
367 | overall_score_text == Your PTSD Score (based on FKBP5 gene)
367 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FKBP5-PTSD.jpg
367 | author_id == 9
367 | author_name == Aleksa Ristic
367 | author_title == MS (Pharmacy)
367 | author_order == 45
367 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
367 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
367 | reviewer == None
367 | medical_reviewer_id == 11
367 | medical_reviewer_name == Puya Yazdi
367 | medical_reviewer_title == MD
367 | publish_date == 2020
367 | publish_date == 9
367 | publish_date == 30
367 | avg_rating == 5.0
367 | tags_id == 688
367 | tags_name == FKBP5 Gene
367 | tags_id == 716
367 | tags_name == Mental Health
367 | tags_id == 6
367 | tags_name == PTSD
367 | tags_id == 50
367 | tags_name == Stress
367 | tags_id == 756
367 | tags_name == Trauma
367 | permissions_favorite == False
367 | permissions_rate == False
367 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The FKBP5 gene controls the stress response. Excess FKBP5 can contribute to stress-related conditions such as PTSD.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific gene variants can increase FKBP5 activity. They can hinder recovery from early life traumas and increase PTSD severity.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Follow our gene-based recommendations to reduce FKBP5 activity and improve stress response.</strong></span></p> <h2><strong>FKBP5, Stress Response &amp; PTSD</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/fkbp5/"><em><span style="font-weight: 400;">FKBP5</span></em></a> <span style="font-weight: 400;">gene regulates different functions in our body, including stress response [</span><a href="https://ghr.nlm.nih.gov/gene/FKBP5"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Excess FKBP5 activity may reduce your ability to recover from stressful events [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27078785/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. It&rsquo;s been associated with stress-related psychiatric disorders like [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19560279/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">Depression</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Bipolar disorder</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a></li> </ul> <h2><strong>Your FKBP5 Results for PTSD</strong></h2> <p>*1231131118841499*</p> <p><a href="../../../snp/rs3800373/"><span style="font-weight: 400;">rs3800373</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27078785/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with PTSD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This variant also correlates with chronic post-traumatic pain</span></li> </ul> <p><a href="../../../snp/rs1360780/"><span style="font-weight: 400;">rs1360780</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27078785/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with PTSD</span></li> </ul> <p><a href="../../../snp/rs9470080/"><span style="font-weight: 400;">rs9470080</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27078785/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with PTSD</span></li> </ul> <p><span style="font-weight: 400;">These variants increase FKBP5 expression and impair stress response. People carrying the risk alleles have a harder time recovering from childhood or early life traumas [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27078785/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136922/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p>*1801350150989902*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Stress &amp; Improve PTSD</strong></h2> <p>*5709644860815417*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Cognitive-Behavioral Therapy</strong></h4> <p><span style="font-weight: 400;">People with FKBP5 variants respond better to cognitive-behavioral therapy for anxiety and stress reduction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26647360/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cognitive-behavioral therapy can improve stress-related disorders such as PTSD, alone or in combination with standard treatment [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26439674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Different therapy forms, such as cognitive processing therapy and narrative exposure therapy, are a part of standard care for PTSD&mdash; consult with a healthcare professional about your options [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345529/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cognitive-behavioral therapy can help with PTSD by targeting your gene variants.</span></p> <h4><strong>Sunlight Exposure</strong></h4> <p><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">Sunlight</span></a><span style="font-weight: 400;"> is your primary source of </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><em><span style="font-weight: 400;">, </span></em><span style="font-weight: 400;">which can reduce</span><em><span style="font-weight: 400;"> FKBP5</span></em><span style="font-weight: 400;"> expression in human cells [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27220430/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research has linked vitamin D deficiency with an increased risk of PTSD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31518608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24604440/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Vitamin D</strong></h4> <p><span style="font-weight: 400;">As mentioned, vitamin D can lessen the impact of your FKBP5 variants on stress &amp; PTSD. If you can&rsquo;t maintain optimal vitamin D levels with sun exposure levels and a balanced diet, consider taking a supplement [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27220430/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31518608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24604440/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
367 | content_snp_table_1231131118841499_key == 1231131118841499
367 | content_snp_table_1231131118841499_blur == True
367 | content_snp_table_1231131118841499_hidden == False
367 | content_learn_more_1801350150989902_key == 1801350150989902
367 | content_learn_more_1801350150989902_blur == True
367 | content_learn_more_1801350150989902_hidden == False
367 | content_learn_more_1801350150989902_text == Based on the variants we looked at, your FKBP5 gene is associated with impaired stress response & slightly higher PTSD severity. However, this doesn't necessarily reflect your overall risk of PTSD, just one gene related to it. Sunlight exposure may help with PTSD by targeting your gene variants. Keep reading to learn more.
367 | content_recommendation_5709644860815417_key == 5709644860815417
367 | content_recommendation_5709644860815417_blur == True
367 | content_recommendation_5709644860815417_hidden == False
rsIDs = rs9470080,rs3800373,rs1360780
rsStatus = rs9470080,FKBP5,chr6,35678658,T,A,C,,33,0,Normal
rsStatus = rs3800373,FKBP5,chr6,35574699,C,A,G,,16,11,HET
rsStatus = rs1360780,FKBP5,chr6,35639794,T,A,C,,28,0,Normal
