37 | id == 37
37 | category_id == 10
37 | category_order == 7
37 | category_name == Detox
37 | category_color == #C47AC0
37 | slug == detox-pesticides-PON1
37 | title == Is This Detox Gene Protecting You From Pesticides? (PON1)
37 | meta_description == PON1 detoxifies pesticides from your body, but not everyone is protected. Find out if you’re at risk and get recommendations.
37 | summary == <p><strong>Pesticides are a growing health concern in many parts of the world. Luckily, the PON1 gene helps protect you by detoxifying a common type of pesticide called organophosphate. But some people may be unprotected. Find out if your genes are limiting your ability to detox and what you can do about it.</strong></p>
37 | overall_score_text == Detox Score (Based on PON1 Gene)
37 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Is-This-Detox-Gene-Protecting-Your-From-Pesticides-PON1_JPG.jpg
37 | author_id == 8
37 | author_name == Mathew Eng
37 | author_title == PharmD
37 | author_order == 40
37 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Mathew.jpg
37 | author_intro == <p><strong>Mathew received his PharmD from the University of Hawaii and an undergraduate degree in Biology from the University of Washington.</strong></p>    <p>Mathew is a licensed pharmacist with clinical experience in oncology, infectious disease, and diabetes management. He has a passion for personalized patient care and believes that education is essential to living a healthy life. His goal is to motivate individuals to find ways to manage their chronic conditions.</p>
37 | reviewer_id == 1
37 | reviewer_name == Jasmine Foster
37 | reviewer_title == BSc, BEd
37 | medical_reviewer_id == 11
37 | medical_reviewer_name == Puya Yazdi
37 | medical_reviewer_title == MD
37 | publish_date == 2019
37 | publish_date == 9
37 | publish_date == 4
37 | avg_rating == 5.0
37 | tags_id == 119
37 | tags_name == Detox
37 | tags_id == 121
37 | tags_name == Organophosphates
37 | tags_id == 39
37 | tags_name == Oxidative Stress
37 | tags_id == 120
37 | tags_name == Pesticides
37 | tags_id == 118
37 | tags_name == Pon1 Gene
37 | tags_id == 122
37 | tags_name == Toxins
37 | permissions_favorite == False
37 | permissions_rate == False
37 | content_article == <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong><span style="font-weight: 400;"> The PON1 gene is mentioned in the <a href="https://get.selfdecode.com/gene-reports/introductory/">Introductory Gene Report</a>, along with many other genes. If you're looking for a comprehensive report about your genes, check it out.</span></td> </tr> </tbody> </table> <p style="text-align: justify;">&nbsp;</p> <h2><span style="font-weight: 400;">What Does The </span><em><span style="font-weight: 400;">PON1 </span></em><span style="font-weight: 400;">Gene Do?</span></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/pon1/"><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> is responsible for encoding a protein with the same name, </span><a href="https://selfhacked.com/blog/about-pon1-and-natural-ways-to-increase-it/"><span style="font-weight: 400;">PON1</span></a><span style="font-weight: 400;">. The protein PON1, short for paraoxonase 1, is an enzyme that hydrolyzes (breaks apart) several different types of chemical bonds [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This ability to break down various molecules makes PON1 vital to your health. It can break apart oxidized fats that could otherwise lead to heart disease, and it can destroy certain parts of harmful bacteria. Perhaps most importantly, PON1 proteins can hydrolyze and therefore </span><a href="https://selfhacked.com/blog/the-science-of-detoxification/"><span style="font-weight: 400;">detoxify</span></a> <strong>organophosphates</strong><span style="font-weight: 400;">, toxic compounds found in pesticides and biological weapons [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene encodes the PON1 protein, which protects you from toxic compounds called organophosphates.</span></span></p> <h3><span style="font-weight: 400;">Organophosphate Toxicity: Are You At Risk?</span></h3> <p><span style="font-weight: 400;">In the U.S., organophosphates are the most commonly used pesticides in farming. Although these pesticides are supposed to degrade when exposed to air and light, there is evidence that organophosphate residue remains on many of the fruits and vegetables we eat [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26687930"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29037495"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The widespread use of pesticides in schools, parks, and other public spaces also puts many people at risk of low-level exposure. Farm workers and military members who have been exposed to nerve agents have an even greater risk of toxicity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200179/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Organophosphates are one of the most commonly used pesticides worldwide and many people are at risk for at least low-level exposure.</span></p> <h3><span style="font-weight: 400;">Health Risks of Organophosphate Toxicity</span></h3> <p><span style="font-weight: 400;">What happens when you&rsquo;re exposed to organophosphates? The symptoms of acute organophosphate poisoning include </span><a href="https://selfhacked.com/blog/people-get-tired-even-enough-sleep/"><span style="font-weight: 400;">fatigue</span></a><span style="font-weight: 400;">, muscle weakness, and paralysis; untreated, it can eventually lead to death [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, if your body isn&rsquo;t properly detoxing organophosphates, even low levels of pesticide exposure can cause harmful effects, including [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26687930"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Infertility</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cancer</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Birth defects</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased risk of Alzheimer&rsquo;s</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased risk of Parkinson&rsquo;s</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased risk of ALS</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exposure to low levels of organophosphates may cause infertility, cancer, birth defects, and neurodegenerative disorders.</span></p> <h2><span style="font-weight: 400;">How The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Gene Can Help (Or Hurt) You</span></h2> <p><span style="font-weight: 400;">Not all PON1 protein is made equal; variations in your </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene can alter the concentration and activity level of the protein. This means that some people are better protected against the toxic effects of organophosphates than others [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More specifically, research has identified two SNPs of the </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene that influence how well your PON1 proteins protect you: rs662 and rs854560 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">*1498957549334489*</span></p> <h3><span style="font-weight: 400;">Enzyme Activity</span></h3> <p><span style="font-weight: 400;">The SNP at </span><a href="../../snp/rs662/"><span style="font-weight: 400;">rs662</span></a><span style="font-weight: 400;"> influences how active the PON1 enzyme is. The normal allele &ldquo;C&rdquo; is associated with normal protein activity and therefore provides the best protection from toxicity. The risk allele &ldquo;T&rdquo; in rs662 reduces the activity of the protein, resulting in less breakdown (and more potential buildup) of toxins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A large analysis of 9 studies including over 2,000 people found that people with the risk allele in rs662 have a 74% higher risk of organophosphate toxicity compared to people without it [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23590198"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Interestingly enough, Caucasians may be at an even higher risk. According to the same study, the risk allele increases the likelihood of toxicity by up to 96% when only looking at Caucasians. On the other hand, the risk allele does not appear to affect Asian populations at all [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23590198"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">In rs662, people with the risk allele &ldquo;T&rdquo; have a 74% greater risk of organophosphate toxicity compared to those without it. The harmful effect of the risk allele is even greater in Caucasians but absent in Asians.</span></p> <h3><span style="font-weight: 400;">Enzyme Concentration</span></h3> <p><span style="font-weight: 400;">The concentration of PON1 protein in the blood is controlled, in part, by rs854560. In this case, the normal allele is &ldquo;T&rdquo; and is associated with normal PON1 levels. The risk allele &ldquo;A&rdquo; is associated with lower blood levels of PON1; if you have less PON1, you have a reduced ability to detox [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The previously mentioned analysis found that people with the risk allele &ldquo;A&rdquo; in rs854560 have an 82% higher risk of organophosphate toxicity compared to people without it [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23590198"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Once again, this effect is amplified in Caucasians; their risk of toxicity jumps up by148% if they have the risk allele. Asians remain unaffected by this risk variant as well. It&rsquo;s not entirely clear why risk alleles affect these two populations differently, but researchers think it may be due to environmental factors [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23590198"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The risk allele &ldquo;A&rdquo; in rs854560 increases the risk of organophosphate toxicity by 82% compared to the normal &ldquo;T&rdquo; allele. This harmful effect is magnified in Caucasians but absent in Asians.</span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Genotype For Organophosphate Toxicity</span></h2> <p>*1498957549334489*</p> <p><strong>Primary SNPs:&nbsp;</strong></p> <p><strong>PON1 rs662</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; allele doesn&rsquo;t increase your risk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; allele increases your risk of toxicity</span></li> </ul> <p>Population Frequency</p> <ul> <li>24% of the world population have "TT"</li> <li>50% of people with European ancestry have "TT"</li> </ul> <p><strong>PON1 rs854560</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; allele doesn&rsquo;t increase your risk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; allele increases your risk of toxicity</span></li> </ul> <p><span style="font-weight: 400;">Population Frequency</span></p> <ul> <li><span style="font-weight: 400;">68% of the world population have "AA"</span></li> <li><span style="font-weight: 400;">41% of people with European ancestry have "AA"</span></li> </ul> <p><span style="font-weight: 400;">Note: </span></p> <ul> <li><span style="font-weight: 400;">Caucasians with a risk allele have an even greater risk for toxicity compared to other groups</span></li> <li><span style="font-weight: 400;">Asians do not appear to be affected by the risk allele</span></li> </ul> <p>*6444229989073564*</p> <h2><span style="font-weight: 400;">How Can You Improve Your </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Genotype?</span></h2> <p><span style="font-weight: 400;">Before trying any of the strategies below, discuss them with your doctor&mdash;and bring along your genetic data! Together, you can figure out if any of these recommendations are right for you.</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">If you&rsquo;re a smoker, quitting may significantly improve your PON1 function. One study of 300 people found that smokers are over 3 times more likely to have low PON1 activity compared to non-smokers. The exact mechanism behind smoking&rsquo;s effects on PON1 is not clear but likely has to do with the many oxidant compounds in cigarettes, which can inhibit PON1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390564/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, exercise is known to activate </span><a href="http://selfhacked.com/blog/ppargamma-role-weight-gain-inflammation-natural-activators/"><span style="font-weight: 400;">PPAR-gamma</span></a><span style="font-weight: 400;">, a receptor responsible for activating the </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene. Studies show that both low- and high-intensity exercise increase the expression and activity of PON1, but the best improvement was seen in those who regularly exercise [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214038/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25735253"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25180827"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It&rsquo;s also important to try to fix any </span><a href="https://selfhacked.com/blog/can-you-boost-your-immune-system-and-lower-inflammation-at-the-same-time/"><span style="font-weight: 400;">inflammation</span></a><span style="font-weight: 400;"> issues you may have. Research has found that compounds that are released during inflammation, such as </span><a href="https://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1b</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;">, can reduce the expression of </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;">. Certain fatty acids like linoleic acid can also lower the activity of PON1 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14511766"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22222492"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Research shows that exercising, quitting cigarettes, and reducing inflammation can significantly improve your PON1 function.</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">According to research, many different types of foods can increase PON1 activity. These foods primarily work as antioxidants, which stop </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidants</span></a><span style="font-weight: 400;"> from inhibiting PON1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Foods and diets that have been shown to increase expression and activity of PON1 include:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Mediterranean Diet [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488773/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">Extra virgin olive oil</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18585720"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">Green tea</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/blueberries-health-benefits/"><span style="font-weight: 400;">Blueberries</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/pomegranate/"><span style="font-weight: 400;">Pomegranate</span></a><span style="font-weight: 400;"> juice [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Dates (Hallawi variety) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Fish oil (DHA)</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120510/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22222492"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/panacea-benefits-broccoli-sprouts-sulforaphane/"><span style="font-weight: 400;">Broccoli sprouts</span></a><span style="font-weight: 400;"> (in cell studies) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22131196"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Mustard and wasabi (in cell studies) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22131196"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">However, it&rsquo;s important to note that some of these findings are based on animal or cell studies. It&rsquo;s not always clear what effect may be seen in humans [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In addition, a polyphenol called </span><a href="https://selfhacked.com/blog/quercetin-23-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">quercetin</span></a><span style="font-weight: 400;"> has been shown to increase PON1 activity by as much as 200%! Foods rich in quercetin include leafy greens, broccoli, red onions, apples, grapes, and tea [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214562/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Foods rich in antioxidants like green tea, blueberries, and pomegranate juice can increase the activity of PON1.</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Similar to the dietary recommendations, several antioxidant supplements can also increase the expression and activity of PON1 and help you detox organophosphates. These include:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/need-know-vitamin-c-32-science-based-health-benefits/"><span style="font-weight: 400;">Vitamin C</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/vitamin-e-can-help-fertility-pregnancy/"><span style="font-weight: 400;">Vitamin E</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/everything-need-know-grapeseed-extract-references/"><span style="font-weight: 400;">Grape seed extract</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28192240"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/berberine-19-health-benefits-of-berberine-with-references/"><span style="font-weight: 400;">Berberine</span></a><span style="font-weight: 400;"> (in cell studies) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21044622"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> (in cell studies) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903941/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15458977"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">Again, some of these supplements were only studied in animal or cell studies; they may not have the same effect in humans [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplements that contain antioxidants like vitamin C &amp; E, curcumin, and grape seed extract may increase PON1 activity.</span></p> <p><span style="font-weight: 400;">*3430097212122063*</span></p> <h3><span style="font-weight: 400;">About the SelfDecode Blog</span></h3> <p><span style="font-weight: 400;">The SelfDecode blog is the first personalized genetics blog in the world, where our content and recommendations change based on </span><em><span style="font-weight: 400;">your</span></em><span style="font-weight: 400;"> genetic data!</span></p> <p><span style="font-weight: 400;">Therefore, to get the full value out of this blog, you should sign up and upload your genetic data.</span></p> <p><span style="font-weight: 400;">If you haven&rsquo;t had your genes tested, then you can order one of our specialized testing kits </span><a href="../../#!#analyze-my-genes"><span style="font-weight: 400;">here</span></a><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">If you're curious, here's</span><a href="https://www.loom.com/share/ec670d4097654467aa55b9e599bc6fda"> <span style="font-weight: 400;">a video of the view when you're logged in.</span></a><span style="font-weight: 400;"> This allows you to see your overall trait score, and how your gene is working in relation to the trait. You'll also see your SNP genotypes relevant to the trait, and -- most importantly -- your personalized lifestyle and supplement recommendations.</span></p>
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37 | content_learn_more_1498957549334489_text == Based on the variants we looked at, your PON1 gene somewhat reduces your ability to detox from organophosphates. Exercise and antioxidant foods/supplements can help. Keep scrolling to find out more.
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rsIDs = rs662,rs854560
rsStatus = rs662,PON1,chr7,95308134,T,A,C,G,28,0,Normal
rsStatus = rs854560,PON1,chr7,95316772,A,C,G,N,25,0,Normal
