372 | id == 372
372 | category_id == 22
372 | category_order == 19
372 | category_name == Trauma
372 | category_color == #C47AC0
372 | slug == CRP-inflammation-PTSD
372 | title == A Gene That Links Inflammation With PTSD (CRP)
372 | meta_description == The CRP gene encodes a crucial inflammatory molecule. Click to learn about its link with PTSD.
372 | summary == <p style="text-align:justify"><strong>Did you know that inflammation can affect mental health? This post reveals a unique genetic link between inflammation, CRP levels, and PTSD &mdash; read on to learn the details and get gene-based tips!</strong></p>
372 | overall_score_text == Your PTSD Score (Based on CRP Gene)
372 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CRP-PTSD.jpg
372 | author_id == 9
372 | author_name == Aleksa Ristic
372 | author_title == MS (Pharmacy)
372 | author_order == 45
372 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
372 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
372 | reviewer == None
372 | medical_reviewer_id == 11
372 | medical_reviewer_name == Puya Yazdi
372 | medical_reviewer_title == MD
372 | publish_date == 2020
372 | publish_date == 10
372 | publish_date == 1
372 | avg_rating == 5.0
372 | tags_id == 258
372 | tags_name == CRP Gene
372 | tags_id == 24
372 | tags_name == Inflammation
372 | tags_id == 6
372 | tags_name == PTSD
372 | tags_id == 50
372 | tags_name == Stress
372 | tags_id == 756
372 | tags_name == Trauma
372 | permissions_favorite == False
372 | permissions_rate == False
372 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>CRP is a crucial inflammatory protein. In excess amounts, it may impair mental health and contribute to PTSD.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Gene variants that increase CRP levels correlate with higher rates and severity of PTSD.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Follow our gene-based recommendations to reduce CRP and improve stress resistance.</strong></span></p> <h2><strong>The Role of CRP and Inflammation in PTSD</strong></h2> <p><span style="font-weight: 400;">Research points to a robust link between </span><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><span style="font-weight: 400;">inflammation</span></a><span style="font-weight: 400;"> and PTSD. People with </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;"> tend to have high levels of inflammatory markers [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26544749/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/c-reactive-protein/"><span style="font-weight: 400;">C-reactive protein</span></a><span style="font-weight: 400;"> or CRP is a primary marker of inflammation, encoded by the </span><a href="../../../gene/crp/"><em><span style="font-weight: 400;">CRP</span></em></a><span style="font-weight: 400;"> gene. It may affect the brain and mental health by disrupting the blood-brain barrier [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26265215/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27810376/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Most studies have observed a positive correlation between blood CRP levels and PTSD, but there&rsquo;s conflicting evidence [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26544749/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24576974/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440454/#R15"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">PTSD is associated with inflammation and increased CRP levels.</span></p> <h2><strong>Your </strong><strong><em>CRP</em></strong><strong> Results for PTSD</strong></h2> <p>*4693271913404744*</p> <p><a href="../../../snp/rs1130864/"><strong>rs1130864</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440454/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher rates and severity of PTSD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with PTSD</span></li> </ul> <p><a href="../../../snp/rs3091244/"><strong>rs3091244</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696006/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18971492/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with a stronger impact of trauma exposure on PTSD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G, A&rsquo; - not associated with PTSD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele also correlates with higher CRP levels</span></li> </ul> <p><a href="../../../snp/rs2794520/"><strong>rs2794520</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696006/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - may be associated with PTSD via increased CRP levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with PTSD</span></li> </ul> <p>*3321325871162362*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Prevent &amp; Improve PTSD</strong></h2> <p>*2456966532430846*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">According to robust clinical evidence, regular </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> can reduce chronic inflammation and CRP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873310/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People who exercise regularly experience less neuroticism, anxiety, and </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-015-1843-x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Both aerobic exercise and resistance training improved PTSD in multiple trials. While aerobic exercise was more effective at improving general anxiety, resistance training helped with specific PTSD symptoms and </span><a href="https://selfhacked.com/blog/sleep-neurophysiology/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> quality [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29049901/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29076530/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29145076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15869081/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24911173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25443996/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31743507/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Strenuous exercise increases the blood levels of </span><a href="https://selfhacked.com/blog/npy/"><span style="font-weight: 400;">NPY</span></a><span style="font-weight: 400;">, a molecule that helps prevent PTSD caused by </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> hormones such as CRH and cortisol [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10807963"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10818263"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise may reduce the impact of your gene variants on PTSD.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Avoid Junk Food</strong></h4> <p><span style="font-weight: 400;">A large study has demonstrated the inverse relationship between diet quality and CRP blood levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833870/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research has associated PTSD with poor diet quality and fewer healthy dietary changes over time [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609606/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24326148/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31769371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In animal studies, consuming a Western-like, </span><a href="http://selfhacked.com/blog/low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">high-fat diet</span></a><span style="font-weight: 400;"> during adolescence increased susceptibility to traumatic stress by altering brain development [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099604/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29428401/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338851/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590222/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">A balanced, high-quality diet may help prevent PTSD by targeting your CRP variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Omega-3</strong></h4> <p><span style="font-weight: 400;">Omega-3 fatty acids from </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> (EPA and DHA) have potent anti-inflammatory effects and may reduce CRP levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155980/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646223/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One study associated PTSD with low blood DHA levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27567082/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Conversely, high blood levels of EPA from omega-3 supplementation correlated with reduced PTSD severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27552592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Omega-3 supplementation prevented </span><a href="https://www.selfhacked.com/blog/resting-heart-rate/"><span style="font-weight: 400;">heart rate</span></a><span style="font-weight: 400;"> spikes in accident survivors with PTSD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27287561/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Omega-3 fatty acids from fish oil may reduce the impact of your gene variants on PTSD.</span></p>
372 | content_snp_table_4693271913404744_key == 4693271913404744
372 | content_snp_table_4693271913404744_blur == True
372 | content_snp_table_4693271913404744_hidden == False
372 | content_learn_more_3321325871162362_key == 3321325871162362
372 | content_learn_more_3321325871162362_blur == True
372 | content_learn_more_3321325871162362_hidden == False
372 | content_learn_more_3321325871162362_text == Based on the variants we looked at, your CRP gene is associated with slightly higher PTSD rates & severity. However, this doesn't necessarily reflect your overall risk of PTSD, just one gene related to it. Regular exercise and a healthy, balanced diet may help with PTSD by targeting your gene variants. Keep reading to learn more.
372 | content_recommendation_2456966532430846_key == 2456966532430846
372 | content_recommendation_2456966532430846_blur == True
372 | content_recommendation_2456966532430846_hidden == False
rsIDs = rs3091244,rs2794520,rs1130864
rsStatus = rs3091244,CRP,chr1,159714875,G,A,T,,20,14,HET
rsStatus = rs2794520,,chr1,159709026,C,A,T,,43,0,Normal
rsStatus = rs1130864,CRP,chr1,159713301,G,A,,,27,17,HET
