377 | id == 377
377 | category_id == 23
377 | category_order == 20
377 | category_name == Depression
377 | category_color == #C47AC0
377 | slug == NEGR1-depression
377 | title == Connecting Nerve Cell Growth & Depression (NEGR1)
377 | meta_description == NEGR1 helps brain cells grow, develop, and form connections with one another. How is it connected to mental health & depression?
377 | summary == <p><strong><em>NEGR1 </em>helps brain cells grow, develop, and form connections with one another. How is it connected to mental health &amp; depression? Find out here.</strong></p>
377 | overall_score_text == Your Depression Score (based on NEGR1)
377 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NEGR1-Depression.jpg
377 | author_id == 1
377 | author_name == Jasmine Foster
377 | author_title == BSc, BEd
377 | author_order == 36
377 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
377 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
377 | reviewer == None
377 | medical_reviewer_id == 11
377 | medical_reviewer_name == Puya Yazdi
377 | medical_reviewer_title == MD
377 | publish_date == 2020
377 | publish_date == 10
377 | publish_date == 2
377 | avg_rating == 5.0
377 | tags_id == 460
377 | tags_name == Brain Development
377 | tags_id == 763
377 | tags_name == Depression
377 | tags_id == 618
377 | tags_name == Major Depression
377 | tags_id == 716
377 | tags_name == Mental Health
377 | tags_id == 459
377 | tags_name == NEGR1 Gene
377 | tags_id == 26
377 | tags_name == Neurogenesis
377 | permissions_favorite == False
377 | permissions_rate == False
377 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <p><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> helps brain cells grow, develop, and form connections with each other. Variants of </span><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> may play a role in depression by reducing the connectivity between brain cells. Diet modifications may help counteract the effects of these variants by increasing NEGR1.</span></p> <h2><em><span style="font-weight: 400;">NEGR1 </span></em><span style="font-weight: 400;">and Depression</span></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/negr1/"><em><span style="font-weight: 400;">NEGR1</span></em></a> <span style="font-weight: 400;">gene encodes the NEGR1 protein (short for &lsquo;neuronal growth regulator 1&rsquo;), also known as kilon or neurotractin. NEGR1 is found in many brain areas such as the hippocampus, olfactory bulb, and cortex, and most abundantly in the </span><a href="https://selfhacked.com/blog/hypothalamus-101/"><span style="font-weight: 400;">hypothalamus</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10330412/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10075727/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12617969/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398851/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As can be guessed from its name, NEGR1 is involved in the growth of brain cells. More specifically, it stimulates the outgrowth of neurons in the developing brain and helps establish connections between these cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15946856/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> has also been implicated in </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">. Animals bred to lack the </span><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> gene displayed depressive symptoms, and some variants in the gene may increase or decrease susceptibility to depression [</span><a href="https://www.nature.com/articles/s41380-018-0347-3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29700475/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">These results suggest that lower than normal NEGR1 activity may lead to depression by reducing connections between neurons [</span><a href="https://www.nature.com/articles/s41380-018-0347-3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many SNPs in the </span><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> gene have been associated with depression. Remember that any one of these variants on its own will likely have a very tiny effect, so it&rsquo;s important to look at the big picture of all of your variants.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> helps brain cells grow, develop, and form connections with one another. Genetic variants that reduce </span><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> have been associated with depression.</span></span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">NEGR1 </span></em><span style="font-weight: 400;">Results for Depression</span></h2> <p>*4593327526746205*</p> <p><strong>NEGR1 </strong><a href="../../../snp/rs2568958/"><strong>rs2568958</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'G' allele may increase NEGR1 expression [</span><a href="https://www.ebi.ac.uk/gwas/publications/30718901"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ebi.ac.uk/gwas/publications/30643256"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs2815752/"><strong>rs2815752</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'G' allele may increase NEGR1 expression [</span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs3101336/"><strong>rs3101336</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'T' allele may increase NEGR1 expression [</span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs7531118/"><strong>rs7531118</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'C' allele may decrease NEGR1 expression [</span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs1993709/"><strong>rs1993709</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'A' allele may increase NEGR1 expression [</span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs990871/"><strong>rs990871</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'C' allele may increase NEGR1 expression [</span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs10789336/"><strong>rs10789336</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'G' allele may increase NEGR1 expression [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/32090785"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs1432639/"><strong>rs1432639</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'C' allele may increase NEGR1 expression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29700475/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3623.html"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>NEGR1 </strong><a href="../../../snp/rs12141660/"><strong>rs12141660</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Less common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = More common in people with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'T' allele may decrease NEGR1 expression [</span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30643256/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p>*8875557119885702*</p> <h2><span style="font-weight: 400;">Recommendations for Improving Depression Symptoms</span></h2> <p>*3265043543622961*</p> <h3><span style="font-weight: 400;">Calorie Restriction</span></h3> <p><span style="font-weight: 400;">In rats, limiting feeding to a 2-hour time window between 1 and 3 PM increased </span><em><span style="font-weight: 400;">NEGR1 </span></em><span style="font-weight: 400;">expression in two brain regions associated with feeding behavior (ventro-medial hypothalamus and substantia nigra) when compared to unrestricted feeding [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22627920"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Calorie restriction and the resulting </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> improved </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and mood in several trials on aging and overweight people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24097021/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627283/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25001959/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A calorie-restricted, low-fat diet showed more favorable effects on mood and anxiety than a low carbohydrate diet without calorie restriction in a weight-loss study followed up for one year [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19901139/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Eating less food and consuming fewer calories may increase </span><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> expression and help with depression symptoms.</span></span></p> <h3><span style="font-weight: 400;">Mediterranean Diet</span></h3> <p><span style="font-weight: 400;">In mice, a Western-style diet rich in fats and refined carbohydrates decreased </span><em><span style="font-weight: 400;">NEGR1 </span></em><span style="font-weight: 400;">expression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18042831/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606106/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The Mediterranean diet is rich in fruits and vegetables, and includes regional foods such as olive oil, nuts, whole grains, fish, and wine. It contains more fiber and polyunsaturated fatty acids (&lsquo;healthy fat&rsquo;) than a standard Western-style diet.</span></p> <p><span style="font-weight: 400;">Adherence to a Mediterranean diet has been associated with lower rates of depression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23720230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29031185/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A Mediterranean-diet intervention supplemented with </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> improved mental health in people with major depression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29215971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A few human studies have associated </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> consumption with a reduced overall risk of depression and improved depressive symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21298116"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18952225"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Consumption of olive oil and </span><a href="https://selfhacked.com/blog/oleic-acid-benefits/"><span style="font-weight: 400;">oleic acid</span></a><span style="font-weight: 400;"> &mdash; the primary fatty acid in olive oil &mdash; reduced depression risk in a large-scale clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19427349"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Western style diets may decrease </span><em><span style="font-weight: 400;">NEGR1</span></em><span style="font-weight: 400;"> compared to Mediterranean style diets, which have also reduced depressive symptoms in clinical trials.</span></span></p>
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377 | content_learn_more_8875557119885702_text == Based on the variants we looked at, your NEGR1 gene is somewhat associated with depression. However, this doesn't necessarily reflect your overall risk of depression; it’s just one gene related to it. Calorie restriction and a Mediterranean diet may help. Keep scrolling to find out more.
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377 | content_recommendation_3265043543622961_blur == True
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rsIDs = rs2568958,rs990871,rs1432639,rs2815752,rs7531118,rs10789336,rs12141660,rs1993709,rs3101336
rsStatus = rs2568958,LOC105378797,chr1,72299433,G,A,C,,9,7,HET
rsStatus = rs990871,LOC105378797,chr1,72358030,C,G,T,,22,0,Normal
rsStatus = rs1432639,LOC105378797,chr1,72347535,C,A,G,T,12,6,HET
rsStatus = rs2815752,LOC105378797,chr1,72346757,G,A,C,,12,7,HET
rsStatus = rs7531118,LOC105378797,chr1,72371556,T,C,,,6,5,HET
rsStatus = rs10789336,LOC105378797,chr1,72372723,G,A,C,,8,3,HET
rsStatus = rs12141660,LOC105378798,chr1,72729877,C,T,,,17,0,Normal
rsStatus = rs1993709,LOC105378797,chr1,72372846,A,C,G,T,10,0,Normal
rsStatus = rs3101336,LOC105378797,chr1,72285502,T,C,,,20,6,HET
