378 | id == 378
378 | category_id == 23
378 | category_order == 20
378 | category_name == Depression
378 | category_color == #C47AC0
378 | slug == ATF6B-depression
378 | title == Can Protein Accumulation Influence Depression? (ATF6B)
378 | meta_description == ATF6B can regulate cell death. Variants of ATF6B have been associated with depression. Read more here.
378 | summary == <p style="text-align:justify"><strong>ATF6&beta; can limit cell death by regulating the activity of the unfolded protein response: a process necessary for getting rid of accumulated proteins. Variants of <em>ATF6B</em> have been associated with depression. Read more to learn about this association, and to learn about recommendations that may mitigate the negative effects of these variants.</strong><br />  &nbsp;</p>
378 | overall_score_text == Your Depression Score (based on ATF6B gene)
378 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TNXB-Depression.jpg
378 | author_id == 14
378 | author_name == Shany Lahan
378 | author_title == MS (Neuroscience)
378 | author_order == 5
378 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
378 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
378 | reviewer == None
378 | medical_reviewer_id == 11
378 | medical_reviewer_name == Puya Yazdi
378 | medical_reviewer_title == MD
378 | publish_date == 2020
378 | publish_date == 10
378 | publish_date == 2
378 | avg_rating == 5.0
378 | tags_id == 216
378 | tags_name == Apoptosis
378 | tags_id == 765
378 | tags_name == ATF6B Gene
378 | tags_id == 769
378 | tags_name == ATF6α
378 | tags_id == 770
378 | tags_name == ATF6β
378 | tags_id == 768
378 | tags_name == Cell Death
378 | tags_id == 475
378 | tags_name == Endoplasmic Reticulum
378 | tags_id == 766
378 | tags_name == Endoplasmic Reticulum Stress
378 | tags_id == 767
378 | tags_name == Unfolded Protein Response
378 | permissions_favorite == False
378 | permissions_rate == False
378 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">ATF6&beta; can limit cell death by regulating the unfolded protein response: a process necessary for getting rid of proteins that have accumulated and caused &ldquo;stress&rdquo; within a region of the cell called the endoplasmic reticulum. Variants of </span><em><span style="font-weight: 400;">ATF6B </span></em><span style="font-weight: 400;">may play a role in depression by lowering production of ATF6&beta; and dysregulating the unfolded protein response, which can ultimately result in excess cell death. Diet and supplement modifications may counteract the effects of these variants by suppressing endoplasmic reticulum stress.</span></span></p> <h2 style="text-align: justify;"><strong><em>ATF6B</em> and Depression</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">Proteins play important roles in a wide array of bodily processes. It&rsquo;s therefore no surprise that they&rsquo;re constantly being made within our cells.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In order for proteins to function properly, they need to be folded into accurate 3D structures within a part of the cell called the endoplasmic reticulum. If proteins are misfolded during this process, cells are usually able to refold them or break them down [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">If misfolded proteins begin to accumulate within the endoplasmic reticulum and cannot be refolded or broken down, the endoplasmic reticulum experiences &ldquo;stress&rdquo; (saturation with proteins), and cells may be targeted for death [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The</span> <span style="font-weight: 400;">unfolded protein response is a system that attempts to get rid of accumulated proteins within the endoplasmic reticulum; if the attempt fails or is prolonged, cells are targeted for death. Players involved in this response can be stimulated by protein ATF6&alpha; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The actions of ATF6&alpha; have been shown to be inhibited by protein ATF6&beta;. By inhibiting ATF6&alpha;, ATF6&beta; may prevent prolonged activation of the unfolded protein response and consequent excess cell death from occurring [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14973138/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666557/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Persistent activation of the unfolded protein response has been implicated in the development of </span><a href="https://selfhacked.com/blog/depression-treatment/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> and other mental disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854536/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, variants of </span><a href="../../../gene/atf6b/"><em><span style="font-weight: 400;">ATF6B</span></em></a> <span style="font-weight: 400;">have been associated with depression. It&rsquo;s possible that these variants may decrease the production of ATF6&beta;, which may prolong the activation of the unfolded protein response and promote cell death in regions of the brain implicated in depression. This can ultimately result in abnormal functioning of these brain regions and amplified depressive symptoms [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your <em>ATF6B</em> Results for Depression</strong></h2> <p style="text-align: justify;">*9388808519282257*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>ATF6B </em></strong><a href="../../../snp/rs2269426/"><strong>rs2269426</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of depression</span><span style="font-weight: 400;">&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>ATF6B </em></strong><a href="../../../snp/rs1150757/"><strong>rs1150757</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression&nbsp;</span></li> </ul> <p style="text-align: justify;"><strong><em>ATF6B </em></strong><a href="../../../snp/rs41316748/"><strong>rs41316748</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;">*8288490283756289*</p> <h2 style="text-align: left;"><strong>Recommendations for Reducing Symptoms of Depression</strong></h2> <p style="text-align: justify;">*6615456510301665*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Luteolin&nbsp;</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/luteolin-benefits/"><span style="font-weight: 400;">Luteolin</span></a><span style="font-weight: 400;"> is a flavonoid found in fruits and vegetables such as apples (skins), celery, broccoli, carrots, and peppers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although the effects of luteolin on depression have not been studied in humans, multiple studies in animals have demonstrated its benefits on depressive symptoms [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23844686/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23925560/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In mice and cell experiments, luteolin was suggested to reduce symptoms of depression by suppressing endoplasmic reticulum stress and consequent cell death [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21881237/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Luteolin may reduce symptoms of depression by suppressing endoplasmic reticulum stress.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Asian Ginseng&nbsp;</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">Ginseng</span></a><span style="font-weight: 400;"> may have anti-inflammatory, antioxidant, anti-stress, and antidepressant effects, according to a few human and animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In two clinical trials focused on postmenopausal women, ginseng was observed to reduce depressive symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10761538"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24088416/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">There are many types of ginseng. Asian ginseng (</span><em><span style="font-weight: 400;">Panax ginseng</span></em><span style="font-weight: 400;">) in particular has been suggested to alleviate symptoms of depression by decreasing the production of proteins involved in endoplasmic reticulum stress [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854536/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Asian ginseng may reduce symptoms of depression by suppressing endoplasmic reticulum stress.</span></p>
378 | content_snp_table_9388808519282257_key == 9388808519282257
378 | content_snp_table_9388808519282257_blur == True
378 | content_snp_table_9388808519282257_hidden == False
378 | content_learn_more_8288490283756289_key == 8288490283756289
378 | content_learn_more_8288490283756289_blur == True
378 | content_learn_more_8288490283756289_hidden == False
378 | content_learn_more_8288490283756289_text == Based on the variants we looked at, your ATF6B gene makes you somewhat more likely to develop depression. However, this doesn't necessarily reflect your overall risk of depression; it’s just one gene related to it. Luteolin and Asian ginseng may help. Keep scrolling to find out more.
378 | content_recommendation_6615456510301665_key == 6615456510301665
378 | content_recommendation_6615456510301665_blur == True
378 | content_recommendation_6615456510301665_hidden == False
rsIDs = rs1150757,rs2269426,rs41316748
rsStatus = rs1150757,TNXB,chr6,32061428,G,A,C,,12,0,Normal
rsStatus = rs2269426,TNXB,chr6,32108722,G,A,,,11,0,Normal
rsStatus = rs41316748,TNXB,chr6,32051735,T,C,,,5,0,Normal
