379 | id == 379
379 | category_id == 23
379 | category_order == 20
379 | category_name == Depression
379 | category_color == #C47AC0
379 | slug == PAX-genes-depression
379 | title == Genes That Link Nerve Growth With Depression (PAX)
379 | meta_description == PAX genes are critical for nerve growth. Click to learn about their link with depression.
379 | summary == <p style="text-align:justify"><strong>One family of genes controlling nerve growth can be your friend or foe when it comes to mental health. Read this post to learn the link between PAX genes and depression &mdash; personalized tips included!</strong></p>
379 | overall_score_text == Your Depression Score (Based on PAX Genes)
379 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PAX5-PAX6-Depression.jpg
379 | author_id == 9
379 | author_name == Aleksa Ristic
379 | author_title == MS (Pharmacy)
379 | author_order == 45
379 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
379 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
379 | reviewer == None
379 | medical_reviewer_id == 11
379 | medical_reviewer_name == Puya Yazdi
379 | medical_reviewer_title == MD
379 | publish_date == 2020
379 | publish_date == 10
379 | publish_date == 3
379 | avg_rating == 5.0
379 | tags_id == 460
379 | tags_name == Brain Development
379 | tags_id == 763
379 | tags_name == Depression
379 | tags_id == 716
379 | tags_name == Mental Health
379 | tags_id == 26
379 | tags_name == Neurogenesis
379 | tags_id == 771
379 | tags_name == PAX5 gene
379 | tags_id == 772
379 | tags_name == PAX6 gene
379 | permissions_favorite == False
379 | permissions_rate == False
379 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The PAX5 and PAX6 genes are crucial for nerve growth and brain development. Impairments in their function have been associated with different mental health disorders.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific PAX variants correlate with higher odds of depression, likely due to their adverse effects on nerve growth.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>There are simple measures you could take to prevent and reduce depression by targeting your PAX variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>How PAX Genes Influence Mental Health</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/pax5/"><span style="font-weight: 400;">PAX5</span></a><span style="font-weight: 400;"> and </span><a href="../../../gene/pax6/"><span style="font-weight: 400;">PAX6</span></a><span style="font-weight: 400;"> genes help make proteins from the PAX family. These proteins control the activity of different genes involved in developing eyes, skin, immune cells, nervous system, and more [</span><a href="https://ghr.nlm.nih.gov/gene/PAX5"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ghr.nlm.nih.gov/gene/PAX6"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists are still investigating the exact role of PAX genes in mental health. Variants in these genes correlate with depression, while more severe mutations can result in mental retardation. The negative effects likely stem from suppressed growth and development of brain cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719768/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740952/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">PAX genes are crucial for brain development and nerve growth. Variants in these genes correlate with depression and other mental health disorders.</span></p> <p>&nbsp;</p> <h2><strong>Your PAX Results for Depression</strong></h2> <p>*4549592732521705*</p> <p><strong>Primary SNPs:</strong></p> <p><strong>PAX5 </strong><a href="../../../snp/rs3824344/"><strong>rs3824344</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ebi.ac.uk/gwas/publications/30643256"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with depression</span></li> </ul> <p><strong>PAX6 </strong><a href="../../../snp/rs1806153/"><strong>rs1806153</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with depression</span></li> </ul> <p><strong>Another important SNP:</strong></p> <p><strong>PAX6 </strong><a href="../../../snp/rs2071754/"><strong>rs2071754</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/abstract/med/27089181"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with depression</span></li> </ul> <p><span style="font-weight: 400;">Most PAX variants also correlate with neuroticism, a tendency toward different negative and disruptive feelings [</span><a href="https://europepmc.org/abstract/med/29255261"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p>*6438574460427207*</p> <h2><strong>Recommendations to Relieve Depression</strong></h2> <p>*4427090570901146*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Sunlight Exposure</strong></h4> <p><span style="font-weight: 400;">Mood issues appear to follow a strong seasonal pattern, being the worst during winter [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23695951"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">Sunlight</span></a><span style="font-weight: 400;"> exposure helps reduce anxiety and depression. It boosts beneficial neurotransmitters and stimulates the growth and development of brain cells thus reducing the impact of your PAX variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC113771/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1687151"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819153/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10816643?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145925/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Insufficient sun exposure is the primary risk factor for </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> deficiency, which correlates with depression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23377209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increased sunlight exposure may prevent depression by targeting your PAX variants.</span></p> <h4><strong>Exercise</strong></h4> <p><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> is one of the best ways to boost nerve growth or neurogenesis naturally</span><span style="font-weight: 400;">, making it an ideal choice for people with PAX variants [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24818140"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425252/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.lww.com/acsm-essr/Fulltext/2002/04000/Exercise_Enhances_and_Protects_Brain_Function.6.aspx"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.neurology.org/content/86/20/1897"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People who exercise regularly have lower rates of </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">. Those with a history of depression are at a lower risk of relapse if they maintain physical fitness [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16439008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20174982"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16639173"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aerobic exercise and resistance training have potent benefits for mental health and depression [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22786489"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26978184"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Regular exercise can lessen the negative impact of your PAX gene on mental health.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Omega-3</strong></h4> <p><span style="font-weight: 400;">Omega-3 fatty acids from </span><a href="https://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">, EPA and DHA, are critical for brain growth and protection. They can help form new connections in the brain regions responsible for mood and emotions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18789910/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140951/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The potential of omega-3s to stimulate nerve growth may be responsible for their beneficial effects on mood and mental health [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045887/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK11853/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Omega-3 supplementation may help both people with clinical depression and non-diagnosed individuals with depressive symptoms. It may also enhance the effectiveness of drug treatment [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24805797"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20586692"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22198441"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">EPA seems to be the most beneficial type of omega-3 for depression-related symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Omega-3 fatty acids from fish oil may reduce depressive symptoms by targeting your PAX variants.</span></p>
379 | content_snp_table_4549592732521705_key == 4549592732521705
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379 | content_learn_more_6438574460427207_text == Based on the variants we looked at, your PAX genes are associated with slightly higher odds of depression. However, this doesn't necessarily reflect your overall risk of depression, just one gene related to it. Regular exercise and sunlight exposure may prevent and reduce depression by targeting your gene variants. Keep reading to learn more.
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rsIDs = rs1806153,rs3824344,rs2071754
rsStatus = rs1806153,PAX6-AS1,chr11,31828558,G,A,C,T,35,0,Normal
rsStatus = rs3824344,PAX5,chr9,37000690,C,G,T,,33,0,Normal
rsStatus = rs2071754,PAX6,chr11,31791034,C,G,T,,31,0,Normal
