380 | id == 380
380 | category_id == 22
380 | category_order == 19
380 | category_name == Trauma
380 | category_color == #C47AC0
380 | slug == nos1-nos1ap-ptsd
380 | title == Nitric Oxide Genes That Can Cause Your Brain Cells To Die From Excitement (NOS1/NOS1AP)
380 | meta_description == Variants of NOS1 and NOS1AP are associated with PTSD. Click here for some diet and gene-based tips!
380 | summary == <p style="text-align:justify">NOS1 and NOS1AP are genes that affect the level of nitric oxide in the brain. When more nitric oxide is produced, your brain becomes over-excited. How does this relate to PTSD? Read on to find out more.</p>
380 | overall_score_text == Your PTSD Score (based on NOS1 and NOS1AP)
380 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NOS1-NOS1AP-PTSD.jpg
380 | author_id == 15
380 | author_name == John Williams
380 | author_title == B.Sc
380 | author_order == 3987
380 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/sinan_pic.png
380 | author_intro == <p>John received his BSc from the University of Toronto.&nbsp;John has spent the last several years teaching high school science and math to English-language learners, which has forced him to learn how to simplify difficult concepts as much as possible. He has also worked in two different research labs and has experience as a student intern working and studying under doctors in hospitals and clinics to help diagnose and treat patients, interpret lab results and fill out mountains of paperwork.</p>
380 | reviewer == None
380 | medical_reviewer_id == 11
380 | medical_reviewer_name == Puya Yazdi
380 | medical_reviewer_title == MD
380 | publish_date == 2020
380 | publish_date == 10
380 | publish_date == 5
380 | avg_rating == 5.0
380 | tags_id == 711
380 | tags_name == GABA
380 | tags_id == 658
380 | tags_name == glutamate
380 | tags_id == 556
380 | tags_name == Nitric Oxide
380 | tags_id == 751
380 | tags_name == NOS1AP Gene
380 | tags_id == 406
380 | tags_name == NOS1 gene
380 | tags_id == 6
380 | tags_name == PTSD
380 | permissions_favorite == False
380 | permissions_rate == False
380 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">NOS1</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> both encode proteins that change the level of nitric oxide in the brain. Variants of these genes</span> <span style="font-weight: 400;">may play a role in PTSD since higher nitric oxide production will increase levels of glutamate, causing brain cells related to memory to die because they are being stimulated too much. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing glutamate levels or by increasing GABA levels, both of which should be able to reduce overall brain cell stimulation.</span></span></p> <h2 style="text-align: justify;"><strong><em>NOS1 </em>and <em>NOS1AP</em> and PTSD</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">NOS1</span></em><span style="font-weight: 400;"> gene encodes nitric oxide synthase 1, a protein responsible for making the gas nitric oxide (NO). The </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> gene encodes the adaptor protein for NOS1, which appears to interact with NOS1 and reduce its effectiveness </span><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/29625171/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28465168/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23146198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Nitric oxide causes glutamate levels to go up and GABA levels to go down. Glutamate is 'excitatory' and is responsible for making your brain active but too much glutamate can overwhelm cells and cause them to die; this is especially a risk for </span><em><span style="font-weight: 400;">NOS1</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> variants that produce higher levels of nitric oxide [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28465168/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23146198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The hippocampus is the part of the brain responsible for memory. The hippocampus will shrink in size when overwhelmed by glutamate; there will be fewer cells and the connections won&rsquo;t be as strong. A small hippocampus is associated with both reduced synaptic plasticity (the ability of your brain to &lsquo;change&rsquo;) as well as a higher risk of PTSD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28465168/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23146198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your <em>NOS1</em> and <em>NOS1AP</em> Results for PTSD</strong></h2> <p style="text-align: justify;"><strong>*4155285500437333*</strong></p> <p style="text-align: justify;"><strong>Primary SNP: [</strong><strong><em>NOS1AP</em></strong><strong>] </strong><a href="https://selfdecode.com/snp/rs386231"><strong>rs386231</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with increased risk of PTSD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with PTSD</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">&lsquo;CC&rsquo; variants are at 3.2 times higher risk of getting PTSD than &lsquo;TT&rsquo; variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23146198/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><strong>Other Important SNPs: [</strong><strong><em>NOS1AP</em></strong><strong>] </strong><a href="https://selfdecode.com/snp/rs10918936"><strong>rs10918936</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with increased PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with PTSD severity</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs: [</strong><strong><em>NOS1AP</em></strong><strong>] </strong><a href="https://selfdecode.com/snp/rs12027674"><strong>rs12027674</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with increased PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = not associated with PTSD severity</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs: [</strong><strong><em>NOS1AP</em></strong><strong>] </strong><a href="https://selfdecode.com/snp/rs10157390"><strong>rs10157390</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with increased PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with PTSD severity</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs: [</strong><strong><em>NOS1AP</em></strong><strong>]</strong> <a href="https://selfdecode.com/snp/rs12725553"><strong>rs12725553</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with increased PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = not associated with PTSD severity</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">All four of the above </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> SNPs are associated with increased PTSD severity.&nbsp;&nbsp;</span></p> <p style="text-align: justify;"><strong>Other Important SNPs: [</strong><strong><em>NOS1</em></strong><strong>]</strong> <a href="https://selfdecode.com/snp/rs10744891"><strong>rs10744891</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with PTSD severity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with decreased PTSD severity</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Unlike the others, this SNP is found in the </span><em><span style="font-weight: 400;">NOS1</span></em><span style="font-weight: 400;"> gene and not the </span><em><span style="font-weight: 400;">NOS1AP</span></em><span style="font-weight: 400;"> gene.&nbsp;</span></p> <p style="text-align: justify;"><strong>*1673477841943249*</strong></p> <h2 style="text-align: justify;"><strong>Recommendations for Improving PTSD</strong></h2> <p style="text-align: justify;"><strong>*6867839422967508*</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">Since too much nitric oxide causes your brain cells to become overexcited and die, the recommendations in this section will focus on decreasing nerve cell stimulation by either decreasing glutamate levels or by increasing GABA [</span><a href="https://www.intechopen.com/books/gaba-and-glutamate-new-developments-in-neurotransmission-research/gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Yoga</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Yoga has been associated with improvements in PTSD symptoms. Yoga has also been found to reduce GABA levels. Since GABA is the main chemical responsible for reducing brain activity, the increase in GABA levels may counteract the brain&rsquo;s hyperactive state in PTSD and therefore prevent the cells of the hippocampus from dying [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22365651/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Yoga may help with PTSD symptoms by decreasing brain cell activity.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Low-Glutamate Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Reducing glutamate intake in your diet may help reduce the hyperactive state of the brain in PTSD. One study of patients with Gulf War Syndrome found that one month of a low glutamate diet seemed to improve both PTSD and anxiety symptoms [</span><a href="https://academic.oup.com/cdn/article/3/Supplement_1/nzz031.FS15-08-19/5518124"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The low glutamate diet requires a bit of research to figure out what is safe to eat. In general, you will want to avoid tomatoes, strong cheeses, certain sauces, anything with MSG, plums, grapes, spinach, mushrooms and most canned foods [</span><a href="https://www.aci.health.nsw.gov.au/__data/assets/pdf_file/0019/286111/Diet-Glutamate-low.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">If you have PTSD, changing to a low-glutamate diet may provide some benefit.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>N-acetylcysteine</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Administration of N-acetylcysteine was found to decrease levels of glutamate in the hippocampus of rats. Human studies have also found that N-acetylcysteine was able to lower glutamate levels in other parts of the brain. Finally, a group of veterans with PTSD who were given N-acetylcysteine appeared to show improvements in their PTSD symptoms. When taken together, these studies suggest that N-acetylcysteine may be able to provide relief for those affected by PTSD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29045497/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30296554/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30141055/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226873/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplementing with N-acetylcysteine may help with PTSD by reducing glutamate levels.</span></p>
380 | content_snp_table_4155285500437333_key == 4155285500437333
380 | content_snp_table_4155285500437333_blur == True
380 | content_snp_table_4155285500437333_hidden == False
380 | content_learn_more_1673477841943249_key == 1673477841943249
380 | content_learn_more_1673477841943249_blur == True
380 | content_learn_more_1673477841943249_hidden == False
380 | content_learn_more_1673477841943249_text == Based on the variants we looked at, your NOS1AP/NOS1 genes makes you somewhat more likely to develop PTSD. However, this doesn't necessarily reflect your overall risk of PTSD; it’s just two genes related to it. Yoga, N-acetylcysteine, and a low glutamate diet may help. Keep scrolling to find out more.
380 | content_recommendation_6867839422967508_key == 6867839422967508
380 | content_recommendation_6867839422967508_blur == True
380 | content_recommendation_6867839422967508_hidden == False
rsIDs = rs10918936,rs10157390,rs12027674,rs10744891,rs386231,rs12725553
rsStatus = rs10918936,NOS1AP,chr1,162232698,A,G,,,16,15,HET
rsStatus = rs10157390,NOS1AP,chr1,162277506,T,C,G,,39,0,Normal
rsStatus = rs12027674,NOS1AP,chr1,162282624,A,C,G,T,28,0,Normal
rsStatus = rs10744891,NOS1,chr12,117284536,G,C,T,,37,0,Normal
rsStatus = rs386231,NOS1AP,chr1,162356033,C,A,T,,37,0,Normal
rsStatus = rs12725553,NOS1AP,chr1,162198326,G,A,T,,17,12,HET
