381 | id == 381
381 | category_id == 23
381 | category_order == 20
381 | category_name == Depression
381 | category_color == #C47AC0
381 | slug == TCF4-depression
381 | title == A Brain Regulator Gene’s Link to Depression (TCF4)
381 | meta_description == The TCF4 gene regulates the growth, development & function of the brain. Could variants of TCF4 cause depression?
381 | summary == <p><strong>The <em>TCF4 </em>gene regulates the growth, development &amp; function of the brain. Could variants of TCF4 cause depression? Read on to learn more.</strong></p>
381 | overall_score_text == Your Depression Score (based on TCF5)
381 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TCF4-Depression.jpg
381 | author_id == 1
381 | author_name == Jasmine Foster
381 | author_title == BSc, BEd
381 | author_order == 36
381 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
381 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
381 | reviewer == None
381 | medical_reviewer_id == 11
381 | medical_reviewer_name == Puya Yazdi
381 | medical_reviewer_title == MD
381 | publish_date == 2020
381 | publish_date == 10
381 | publish_date == 6
381 | avg_rating == 5.0
381 | tags_id == 460
381 | tags_name == Brain Development
381 | tags_id == 763
381 | tags_name == Depression
381 | tags_id == 618
381 | tags_name == Major Depression
381 | tags_id == 716
381 | tags_name == Mental Health
381 | tags_id == 12
381 | tags_name == Mood
381 | tags_id == 773
381 | tags_name == TCF4 Gene
381 | permissions_favorite == False
381 | permissions_rate == False
381 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <p><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> encodes a protein that regulates the growth, development, and everyday function of the brain. Variants of </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> may play a role in depression by reducing the expression of other genes controlled by the TCF4 protein. Diet modifications may counteract the effects of these variants by increasing </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> expression.</span></p> <h2><em><span style="font-weight: 400;">TCF4 </span></em><span style="font-weight: 400;">and Depression</span></h2> <p><em><span style="font-weight: 400;">TCF4 </span></em><span style="font-weight: 400;">encodes a protein called transcription factor 4, which helps control the expression of other genes [</span><a href="https://medlineplus.gov/genetics/gene/tcf4/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many of the genes regulated by TCF4 appear to help with the growth, development, and everyday function of the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28341444/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://jhu.pure.elsevier.com/en/publications/disruption-of-tcf4-regulatory-networks-leads-to-abnormal-cortical"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some mutations in the </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> gene can cause Pitt-Hopkins syndrome. This genetic disorder is characterized by intellectual disability, developmental delay, breathing problems, and seizures [</span><a href="https://medlineplus.gov/genetics/condition/pitt-hopkins-syndrome/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, many variants of </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> have much less obvious or severe effects. Several, for example, have been associated with </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> in otherwise cognitively normal people [</span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some researchers believe that any disruption of normal TCF4 function could lead to problems in the brain, ranging from depression to mental disability. In one study, patients with depression had significantly lower levels of </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> gene expression than their healthy counterparts did [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28341444/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://jhu.pure.elsevier.com/en/publications/disruption-of-tcf4-regulatory-networks-leads-to-abnormal-cortical"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> regulates genes that help with the growth, development, and everyday function of the brain. Genetic variants that reduce </span><em><span style="font-weight: 400;">TCF4 </span></em><span style="font-weight: 400;">expression have been associated with depression.</span></span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">TCF4 </span></em><span style="font-weight: 400;">Results for Depression</span></h2> <p>*6678271922774093*</p> <p><strong>TCF4 </strong><a href="../../../snp/rs1452787/"><strong>rs1452787</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs9951150/"><strong>rs9951150</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs4800995/"><strong>rs4800995</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs11152363/"><strong>rs11152363</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs12958048/"><strong>rs12958048</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs56403421/"><strong>rs56403421</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs1452788/"><strong>rs1452788</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29662059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs12457157/"><strong>rs12457157</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs12963463/"><strong>rs12963463</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs1261070/"><strong>rs1261070</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TCF4 </strong><a href="../../../snp/rs2958162/"><strong>rs2958162</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">[</span><a href="https://europepmc.org/abstract/med/29942085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p>*7688664364414561*</p> <h2><span style="font-weight: 400;">Recommendations for Improving Depressive Symptoms</span></h2> <p>*6547002018109249*</p> <h3><span style="font-weight: 400;">Olive Oil</span></h3> <p><span style="font-weight: 400;">In a cell study, </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">extra-virgin olive oil</span></a><span style="font-weight: 400;"> increased the expression of the </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> gene. The authors of the study attribute the increase in </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> to the active plant compounds in the oil, so it&rsquo;s important to seek out a high-quality extra-virgin olive oil [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283896/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A few human studies have associated </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> consumption with a reduced overall risk of depression and improved depressive symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21298116"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18952225"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Consumption of olive oil and </span><a href="https://selfhacked.com/blog/oleic-acid-benefits/"><span style="font-weight: 400;">oleic acid</span></a><span style="font-weight: 400;"> &mdash; the primary fatty acid in olive oil &mdash; reduced depression risk in a large-scale clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19427349"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Early evidence suggests that olive oil may act by increasing the release and turnover of </span><a href="https://selfhacked.com/blog/dopamine/"><span style="font-weight: 400;">dopamine</span></a><span style="font-weight: 400;">. Moreover, the oleic acid byproduct oleamide may increase neurotransmitter binding to </span><a href="https://www.selfhacked.com/blog/how-to-increase-serotonin"><span style="font-weight: 400;">serotonin</span></a><span style="font-weight: 400;"> receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19239627"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The Mediterranean diet is rich in olive oil and has been associated with lower rates of depression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23720230/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29031185/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The active plant compounds in olive oil may increase </span><em><span style="font-weight: 400;">TCF4</span></em><span style="font-weight: 400;"> and reduce depressive symptoms.</span></span></p>
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381 | content_learn_more_7688664364414561_text == Based on the variants we looked at, your TCF4 gene is somewhat associated with depression. However, this doesn't necessarily reflect your overall risk of depression; it’s just one gene related to it. A diet rich in olive oil may help. Keep scrolling to find out more.
381 | content_recommendation_6547002018109249_key == 6547002018109249
381 | content_recommendation_6547002018109249_blur == True
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rsStatus = rs4800995,LOC105372130,chr18,55748146,G,A,C,,6,29,HET
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