382 | id == 382
382 | category_id == 24
382 | category_order == 21
382 | category_name == Acne
382 | category_color == #C47AC0
382 | slug == TNF-inflammation-acne
382 | title == Genetic Link Between Acne and Inflammation (TNF)
382 | meta_description == TNF-alpha and inflammation play a key role in acne development. Here’s how your genes are involved.
382 | summary == <p style="text-align:justify"><strong>By controlling inflammation, your genes can have a major impact on acne development. Read this post to learn about the link between TNF-alpha and acne.</strong></p>
382 | overall_score_text == Your Acne Score (based on TNF genes)
382 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TNF-Acne.jpg
382 | author_id == 9
382 | author_name == Aleksa Ristic
382 | author_title == MS (Pharmacy)
382 | author_order == 45
382 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
382 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
382 | reviewer == None
382 | medical_reviewer_id == 11
382 | medical_reviewer_name == Puya Yazdi
382 | medical_reviewer_title == MD
382 | publish_date == 2020
382 | publish_date == 10
382 | publish_date == 6
382 | avg_rating == 5.0
382 | tags_id == 774
382 | tags_name == Acne
382 | tags_id == 24
382 | tags_name == Inflammation
382 | tags_id == 776
382 | tags_name == Skin health
382 | tags_id == 235
382 | tags_name == TNF-alpha
382 | tags_id == 234
382 | tags_name == TNF gene
382 | tags_id == 775
382 | tags_name == TNFRSF1B gene
382 | permissions_favorite == False
382 | permissions_rate == False
382 | content_article == <p>&nbsp;</p> <table style="height: 56px; width: 100%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong> <em>TNF</em> is one of the genes analyzed in our <strong><a href="https://get.selfdecode.com/gene-reports/inflammation/"><em>Inflammation DNA Wellness Report</em></a></strong>, along with many other genes. If you're looking for a comprehensive report on inflammation-related genes, check it out!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Skin inflammation and increased TNF-alpha play a crucial role in acne development.<br /><br /></strong><strong>Different gene variants can affect acne development by changing the levels of TNF-alpha.<br /><br /></strong><strong>Follow our gene-based recommendations to combat acne and improve skin health.</strong></span></p> <p>&nbsp;</p> <h2><strong>TNF Genes, Inflammation &amp; Acne</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/tnf/"><span style="font-weight: 400;">TNF</span></a><span style="font-weight: 400;"> gene helps produce </span><a href="https://selfhack.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;">, a crucial inflammatory protein. The </span><a href="https://selfdecode.com/gene/tnfrsf1b/"><span style="font-weight: 400;">TNFRSF1B</span></a><span style="font-weight: 400;"> gene helps make a receptor for TNF-alpha, enabling its biological functions [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7124"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ghr.nlm.nih.gov/gene/TNFRSF1B"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Inflammation plays a central role in the development of </span><a href="https://selfhacked.com/blog/everything-need-know-acne/"><span style="font-weight: 400;">acne</span></a><span style="font-weight: 400;">. People with acne have increased TNF gene expression in the skin, which stimulates other cytokines and drives inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12592074"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15679586"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your TNF Results for Acne</strong></h2> <p>*9756242939693893*</p> <p><strong>Primary SNP:&nbsp;</strong></p> <p><strong>TNF </strong><a href="https://selfdecode.com/snp/rs1800629/"><strong>rs1800629</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912133/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele increases TNF-a levels</span></li> </ul> <p><strong>Other important SNPs:</strong></p> <p><strong>TNF </strong><a href="https://selfdecode.com/snp/rs1799724/"><strong>rs1799724</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20386917/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher odds of acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely increases TNF-a levels</span></li> </ul> <p><strong>TNFRSF1B</strong> <a href="https://selfdecode.com/snp/rs1061622/"><span style="font-weight: 400;">rs1061622</span></a><span style="font-weight: 400;"> [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/20861605"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele increases TNF-a receptor activity</span></li> </ul> <p><span style="font-weight: 400;">TNF gene variants modify the link between inflammation and many other health conditions, such as:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/tnf-chronic-pain-313/"><span style="font-weight: 400;">Chronic pain</span></a></li> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/tnf-ards-137/"><span style="font-weight: 400;">Lung failure</span></a></li> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/tnf-inflammation-ibd-170/"><span style="font-weight: 400;">IBD</span></a></li> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/tnf-thyroid-health-89/"><span style="font-weight: 400;">Thyroid Autoimmunity</span></a></li> <li style="font-weight: 400;"><a href="https://selfdecode.com/blog/article/tnf-inflammation-obesity-208/"><span style="font-weight: 400;">Obesity</span></a></li> </ul> <p>*6421222663305248*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Acne</strong></h2> <p>*3633819521241614*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Reduce Stress</strong></h4> <p><span style="font-weight: 400;">Psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> is associated with higher TNF gene expression and TNF-alpha blood levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553449/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595533/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TNF-alpha and other substances released during stress increase fat production and inflammation in the skin, paving the way for acne [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9828880/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124543/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Studies in adolescents and young adults have associated </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> with increased acne severity, especially in males [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17340019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12873885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Stress may also slow the repair of acne wounds [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10232300/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a small clinical trial, a relaxation therapy helped improve acne [</span><a href="https://pubmed.ncbi.nlm.nih.gov/6224928/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoid stress and practice your favorite relaxation techniques to lower the impact of your TNF genes on acne development.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Fatty Fish (Omega-3)</strong></h4> <p><span style="font-weight: 400;">Omega-3 fatty acids from </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> (DHA and EPA) can reduce TNF gene expression and blood levels. Their anti-inflammatory effects are crucial for people with acne, especially for those with TNF variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28478481/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10617994/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several studies have associated low dietary intake of fish and seafood (omega-3 sources) with increased acne incidence and severity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20822969/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22386050/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037798/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fatty sea fish such as mackerel, salmon, sardines, and herrings are especially rich in EPA and DHA [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22122770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increased intake of fatty sea fish can prevent acne by targeting your TNF genes.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Omega-3</strong></h4> <p><span style="font-weight: 400;">If you don&rsquo;t eat at least two servings of fatty sea fish per week, consider taking an omega-3 supplement to counteract your TNF genes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12438303/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fish oil supplementation reduced acne severity in two clinical trials and a few case studies, especially for those with moderate-to-severe acne [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543297/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24553997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577647/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
382 | content_snp_table_9756242939693893_key == 9756242939693893
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382 | content_learn_more_6421222663305248_text == Based on the variants we looked at, your TNF genes are associated with slightly higher odds of developing acne. However, this doesn't necessarily reflect your overall risk of acne; it’s just a genetic factor related to it. Try to avoid stress and eat more fatty fish to reduce the impact of your genes. Keep scrolling to find out more.
382 | content_recommendation_3633819521241614_key == 3633819521241614
382 | content_recommendation_3633819521241614_blur == True
382 | content_recommendation_3633819521241614_hidden == False
rsIDs = rs1061622,rs1799724,rs1800629
rsStatus = rs1061622,TNFRSF1B,chr1,12192898,T,G,,,27,16,HET
rsStatus = rs1799724,LTA,chr6,31574705,C,T,,,4,0,Normal
rsStatus = rs1800629,TNF,chr6,31575254,G,A,,,9,0,Normal
