383 | id == 383
383 | category_id == 23
383 | category_order == 20
383 | category_name == Depression
383 | category_color == #C47AC0
383 | slug == CRHR1-depression
383 | title == A Genetic Link Between Emotional Memories & Depression (CRHR1)
383 | meta_description == CRHR1 is involved in fear-based memory consolidation. Variants of CRHR1 have been associated with depression. Read more here.
383 | summary == <p style="text-align:justify"><strong>The <em>CRHR1 </em>gene codes for a receptor that is involved in fear-based memory consolidation. Variants of <em>CRHR1 </em>have been associated with depression. Read more to learn about this association, and to learn about recommendations you may follow to mitigate the negative effects of these variants.</strong></p>
383 | overall_score_text == Your Depression Score (based on CRHR1 gene)
383 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CRHR1-MAPT-Depression.jpg
383 | author_id == 14
383 | author_name == Shany Lahan
383 | author_title == MS (Neuroscience)
383 | author_order == 5
383 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
383 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
383 | reviewer == None
383 | medical_reviewer_id == 11
383 | medical_reviewer_name == Puya Yazdi
383 | medical_reviewer_title == MD
383 | publish_date == 2020
383 | publish_date == 10
383 | publish_date == 6
383 | avg_rating == 5.0
383 | tags_id == 479
383 | tags_name == ACTH
383 | tags_id == 742
383 | tags_name == Amygdala
383 | tags_id == 777
383 | tags_name == Corticotropin-Releasing Hormone
383 | tags_id == 416
383 | tags_name == Cortisol
383 | tags_id == 417
383 | tags_name == CRH
383 | tags_id == 418
383 | tags_name == CRHR1 gene
383 | tags_id == 415
383 | tags_name == HPA axis
383 | permissions_favorite == False
383 | permissions_rate == False
383 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">CRHR1 </span></em><span style="font-weight: 400;">codes for a receptor that binds CRH. CRH is a hormone that influences the consolidation of fear-based memories by acting on a region of the brain called the amygdala. Variants of </span><em><span style="font-weight: 400;">CRHR1 </span></em><span style="font-weight: 400;">may play a role in depression by altering the activity of the CRH receptor, thus promoting abnormal consolidation of fear-based memories. Lifestyle modifications may counteract the effects of these variants by altering maladaptive thinking patterns and regulating fear-based memory consolidation.&nbsp;</span></span></p> <h2 style="text-align: justify;"><strong><em>CRHR1</em> and Depression</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/crhr1/"><em><span style="font-weight: 400;">CRHR1 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for a receptor that binds </span><a href="https://selfhacked.com/blog/why-your-health-problems-worsen-after-stress-the-role-of-crh/"><span style="font-weight: 400;">corticotropin-releasing hormone</span></a><span style="font-weight: 400;"> (CRH).&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">CRH plays a major role in the </span><a href="https://selfhacked.com/blog/reasons-cortisol-low-high/"><span style="font-weight: 400;">HPA axis</span></a><span style="font-weight: 400;">, where it is released from a region of the brain called the hypothalamus and subsequently binds to its receptors in the pituitary gland to stimulate the release of </span><a href="https://selfhacked.com/blog/acth/"><span style="font-weight: 400;">ACTH</span></a><span style="font-weight: 400;">. ACTH, in turn, mediates the release of the stress-related hormone </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;"> from the adrenal glands [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Both overactivity and underactivity of the HPA axis have been linked to different subtypes of major depressive disorder. With overactivity of the HPA axis, elevated levels of CRH, ACTH, and cortisol can be observed (and vice versa) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11920153/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Apart from its receptors within the pituitary gland, CRH receptors can be found in the amygdala, a region of the brain implicated in emotional memory consolidation. Interestingly, excess CRH acting on the amygdala has been suggested to enhance the consolidation of fear-based memories, which may precede trauma-induced depression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15129783/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20957648"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22748421"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">CRHR1 </span></em><span style="font-weight: 400;">have been associated with depression. These variants may increase or decrease the activity of CRH receptors in the amygdala, resulting in abnormal consolidation of emotional memories and consequent symptoms of depression.&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your <em>CRHR1</em> Results for Depression</strong></h2> <p style="text-align: justify;">*8356909416290934*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>CRHR1 </em></strong><a href="https://selfdecode.com/snp/rs17689882/"><strong>rs17689882</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of depression&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>CRHR1 </em></strong><a href="https://selfdecode.com/snp/rs1724422/"><strong>rs1724422</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;"><strong><em>CRHR1 </em></strong><a href="https://selfdecode.com/snp/rs110402/"><strong>rs110402</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;"><strong><em>CRHR1 </em></strong><a href="https://selfdecode.com/snp/rs9303521/"><strong>rs9303521</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;"><strong><em>CRHR1 </em></strong><a href="https://selfdecode.com/snp/rs2435200/"><strong>rs2435200</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of depression</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;"><strong><em>CRHR1 </em></strong><a href="https://selfdecode.com/snp/rs12938031/"><strong>rs12938031</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of depression&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with depression</span></li> </ul> <p style="text-align: justify;">*3789304189699121*</p> <h2 style="text-align: left;"><strong>Recommendations for Reducing Symptoms of Depression</strong></h2> <p style="text-align: justify;">*4140593089471811*</p> <p style="text-align: justify;"><span style="font-weight: 400;">Since overactive and underactive CRH receptors have both been associated with different subtypes of depression, individuals carrying </span><em><span style="font-weight: 400;">CRHR1 </span></em><span style="font-weight: 400;">risk variants should focus on altering their maladaptive thinking patterns in an effort to regulate their consolidation of fear-based memories.</span></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Cognitive-Behavioral Therapy (CBT)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Cognitive-behavioral therapy is a technique that aims to reduce symptoms of depression in individuals by promoting awareness of their maladaptive thinking patterns and behaviors [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9635215"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Cognitive-behavioral therapy has been shown to improve symptoms of mood disorders such as major depression, seasonal affective disorder, and postpartum depression as effectively as other psychotherapies and antidepressant medications [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933381/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26539881"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9099116"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cognitive-behavioral therapy may reduce symptoms of depression by modifying maladaptive thinking patterns.&nbsp;</span></p> <h4 style="text-align: justify;"><strong>Psychodynamic Therapy</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Psychodynamic therapy focuses on unconscious thoughts and feelings related to past experiences. Similar to cognitive-behavioral therapy, this is done in order to promote awareness of unconscious thoughts and feelings, and change current behavior.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The effectiveness of psychodynamic therapy for symptoms of depression is well-supported. In some cases, this therapy was as effective as prescription antidepressants [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26281018"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a clinical trial, psychodynamic therapy delivered for 10 weeks via the internet reduced symptoms of mood and anxiety disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23862104"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Psychodynamic therapy may reduce symptoms of depression by modifying unconscious maladaptive thinking patterns.</span></p>
383 | content_snp_table_8356909416290934_key == 8356909416290934
383 | content_snp_table_8356909416290934_blur == True
383 | content_snp_table_8356909416290934_hidden == False
383 | content_learn_more_3789304189699121_key == 3789304189699121
383 | content_learn_more_3789304189699121_blur == True
383 | content_learn_more_3789304189699121_hidden == False
383 | content_learn_more_3789304189699121_text == Based on the variants we looked at, your CRHR1 gene makes you somewhat more likely to develop depression. However, this doesn't necessarily reflect your overall risk of depression; it’s just one gene related to it. Cognitive-behavioral therapy and psychodynamic therapy may help. Keep scrolling to find out more.
383 | content_recommendation_4140593089471811_key == 4140593089471811
383 | content_recommendation_4140593089471811_blur == True
383 | content_recommendation_4140593089471811_hidden == False
rsIDs = rs2435200,rs9303521,rs1724422,rs17689882,rs110402,rs12938031
rsStatus = rs2435200,MAPT,chr17,45994485,G,A,,,16,0,Normal
rsStatus = rs9303521,LINC02210-CRHR1,chr17,45727828,T,C,G,,5,0,Normal
rsStatus = rs1724422,LINC02210-CRHR1,chr17,45699947,A,G,,,10,0,Normal
rsStatus = rs17689882,CRHR1,chr17,45829462,G,A,,,14,0,Normal
rsStatus = rs110402,CRHR1,chr17,45802681,G,A,C,,8,4,HET
rsStatus = rs12938031,LINC02210-CRHR1,chr17,45777136,A,G,,,17,0,Normal
