384 | id == 384
384 | category_id == 24
384 | category_order == 21
384 | category_name == Acne
384 | category_color == #C47AC0
384 | slug == TGFB2-acne
384 | title == Is Your Skin Prone to Trapping Acne Bacteria? (TGFB2)
384 | meta_description == TGFB2 coordinates the growth & healing of skin & prevents bacterial growth in the pores. Which variants are linked to acne?
384 | summary == <p><strong><em>TGFB2 </em>coordinates the growth and healing of skin &amp; prevents bacterial growth in the pores. Which variants are linked to acne? Find out here.</strong></p>
384 | overall_score_text == Your Acne Score (based on TGFB2)
384 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TGFB2-NXNP1-RRP15-Acne.jpg
384 | author_id == 1
384 | author_name == Jasmine Foster
384 | author_title == BSc, BEd
384 | author_order == 36
384 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
384 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
384 | reviewer == None
384 | medical_reviewer_id == 11
384 | medical_reviewer_name == Puya Yazdi
384 | medical_reviewer_title == MD
384 | publish_date == 2020
384 | publish_date == 10
384 | publish_date == 6
384 | avg_rating == 5.0
384 | tags_id == 774
384 | tags_name == Acne
384 | tags_id == 779
384 | tags_name == Exfoliation
384 | tags_id == 378
384 | tags_name == Growth
384 | tags_id == 776
384 | tags_name == Skin health
384 | tags_id == 778
384 | tags_name == TGFB2 Gene
384 | tags_id == 780
384 | tags_name == Wound Healing
384 | permissions_favorite == False
384 | permissions_rate == False
384 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <p><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> encodes transforming growth factor-beta2, a signalling protein that coordinates the growth and healing of the skin. Variants of </span><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> may play a role in acne by failing to regulate keratinocytes, leading to clogged pores. Lifestyle and supplement modifications may counteract the effects of these variants by increasing TGF-&beta;2 and opening clogged pores.</span></p> <h2><em><span style="font-weight: 400;">TGFB2 </span></em><span style="font-weight: 400;">and Acne</span></h2> <p><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> encodes transforming growth factor-beta2, a signalling protein that coordinates the growth, development, and movement of some types of cells [</span><a href="https://medlineplus.gov/genetics/gene/tgfb2/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TGF-&beta; proteins are heavily involved in the growth and healing of the skin. More specifically, TGFB2 slows down the reproduction of a type of skin cells called keratinocytes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857353/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507494/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms5020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some amount of keratinocytes are required in healthy skin, but if there are too many, they can clog up hair follicles, providing a place for bacteria to grow and potentially causing acne [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857353/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507494/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/ncomms5020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One study found that people with acne tended to have reduced </span><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> gene activity in their skin, compared to people with clear skin. Researchers also identified one variant in the </span><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> gene, rs1159268, which was associated with acne [</span><a href="https://www.nature.com/articles/ncomms5020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">TGFB2 </span></em><span style="font-weight: 400;">regulates the growth and healing of skin. If </span><em><span style="font-weight: 400;">TGFB2 </span></em><span style="font-weight: 400;">is reduced, keratinocytes may reproduce out of control, clogging up hair follicles and allowing the growth of acne bacteria.</span></span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">TGFB2 </span></em><span style="font-weight: 400;">Results for Acne</span></h2> <p>*5147440338796478*</p> <p><strong>TGFB2 </strong><a href="https://selfdecode.com/snp/rs1159268/"><strong>rs1159268</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with increased likelihood of acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;AA&rsquo; genotype may reduce </span><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> gene expression and is significantly more common in people with severe acne [</span><a href="https://www.nature.com/articles/ncomms5020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*5390387107722943*</p> <h2><span style="font-weight: 400;">Recommendations for Improving Acne</span></h2> <p>*3047621393533875*</p> <h3><span style="font-weight: 400;">Light Therapy</span></h3> <p><span style="font-weight: 400;">In acne-affected skin, light therapy may reduce inflammation by boosting TGF-beta. <a href="https://selfhacked.com/blog/red-light-therapy-benefits/">Red light</a>, <a href="https://selfhacked.com/blog/blue-light-therapy-benefits/">blue light</a>, or a combination of the two may help improve acne [<a href="https://pubmed.ncbi.nlm.nih.gov/23992161/">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/16965424/">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/19239470/">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/10809858/">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/28338214/">R</a>].</span></p> <h3><span style="font-weight: 400;">Exfoliation</span></h3> <p><span style="font-weight: 400;">Exfoliation is the removal of dead skin cells by using a brush/scrub or applying an acid that dissolves them. Exfoliation is believed to help with acne by removing the skin cells that clog pores and allowing anti-acne treatments to penetrate deeper. This process is especially important for people with low-expression </span><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> variants, who may be more prone to clogged pores [</span><a href="https://www.nature.com/articles/ncomms5020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A number of studies support the use of exfoliation with chemicals such as salicylic acid, </span><a href="http://selfhacked.com/blog/the-brains-secret-backup-generator/"><span style="font-weight: 400;">lactic acid</span></a><span style="font-weight: 400;">, Jessner&rsquo;s solution, and phenol as an adjuvant therapy for acne [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053170/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another method of exfoliation (microdermabrasion) improved acne and scarring in two small trials [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11442587/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11298700/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Because people with low-expression </span><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> variants may be more prone to clogged pores, it is especially important to exfoliate dead skin cells.</span></span></p> <h3><span style="font-weight: 400;">Aloe Vera</span></h3> <p><span style="font-weight: 400;">Some cell-based research suggests that aloe may increase the expression of </span><em><span style="font-weight: 400;">TGFB2 </span></em><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911224/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/aloe-vera-benefits/"><span style="font-weight: 400;">Aloe vera</span></a><span style="font-weight: 400;"> helps fight bacteria, reduce inflammation, and promote wound healing when applied on the skin, making it a popular treatment for a variety of skin conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2810076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19218914/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aloe components such as lupeol, salicylic acid, </span><a href="http://selfhacked.com/blog/causes-of-high-or-low-blood-urea-nitrogen-bun/"><span style="font-weight: 400;">urea</span></a><span style="font-weight: 400;"> nitrogen, cinnamic acid, phenols, and sulfur can all fight acne-causing bacteria [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011368/full"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A topical gel with aloe vera combined with tretinoin cream was more effective for acne than either treatment alone in a clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23336746?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In another study, a topical lotion with aloe vera and clove-</span><a href="https://www.selfhacked.com/blog/basil-oil/"><span style="font-weight: 400;">basil oil</span></a><span style="font-weight: 400;"> improved acne. The higher the concentration of aloe vera in the preparation, the more effective it was [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S0962456203001413"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Limited evidence suggests that aloe vera may increase the expression of </span><em><span style="font-weight: 400;">TGFB2</span></em><span style="font-weight: 400;"> and help clear acne bacteria if applied to the skin.</span></span></p>
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384 | content_learn_more_5390387107722943_key == 5390387107722943
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384 | content_learn_more_5390387107722943_text == Based on the variants we looked at, your TGFB2 gene is somewhat associated with acne. However, this doesn't necessarily reflect your overall risk of acne; it’s just one gene related to it. Exfoliation and aloe vera gel may help. Keep scrolling to find out more.
384 | content_recommendation_3047621393533875_key == 3047621393533875
384 | content_recommendation_3047621393533875_blur == True
384 | content_recommendation_3047621393533875_hidden == False
rsIDs = rs1159268
rsStatus = rs1159268,,chr1,218671564,G,A,,,36,0,Normal
