386 | id == 386
386 | category_id == 24
386 | category_order == 21
386 | category_name == Acne
386 | category_color == #C47AC0
386 | slug == FST-acne-TGF
386 | title == A Surprising Genetic Factor for Acne (FST)
386 | meta_description == The FST gene helps produce follistatin, which inhibits TGF-beta. Learn how that’s all related to acne.
386 | summary == <p style="text-align:justify"><strong>Follistatin is popular among bodybuilders, but its role in skin health and acne development is less known. This post reveals the link between the FST gene, TGF-beta &amp; acne.</strong></p>
386 | overall_score_text == Your Acne Score (Based on FST Gene)
386 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FST-Acne.jpg
386 | author_id == 9
386 | author_name == Aleksa Ristic
386 | author_title == MS (Pharmacy)
386 | author_order == 45
386 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
386 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
386 | reviewer == None
386 | medical_reviewer_id == 11
386 | medical_reviewer_name == Puya Yazdi
386 | medical_reviewer_title == MD
386 | publish_date == 2020
386 | publish_date == 10
386 | publish_date == 7
386 | avg_rating == 5.0
386 | tags_id == 774
386 | tags_name == Acne
386 | tags_id == 787
386 | tags_name == follistatin
386 | tags_id == 786
386 | tags_name == FST gene
386 | tags_id == 24
386 | tags_name == Inflammation
386 | tags_id == 785
386 | tags_name == TGF-beta
386 | permissions_favorite == False
386 | permissions_rate == False
386 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The FST gene helps produce follistatin, which may contribute to acne development by inhibiting TGF-beta.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>One FST variant has been associated with higher odds of developing acne.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>There are simple ways to prevent and improve acne by targeting the FST gene.</strong></span></p> <p>&nbsp;</p> <h2><strong>The Role of FST in Acne Development</strong></h2> <p><span style="font-weight: 400;">The <em><a href="https://selfdecode.com/gene/fst/" target="_blank" rel="noopener">FST</a></em> gene helps produce </span><a href="https://www.selfhacked.com/blog/follistatin/"><span style="font-weight: 400;">follistatin</span></a><span style="font-weight: 400;">, which inhibits </span><a href="http://selfhacked.com/blog/tgf/"><span style="font-weight: 400;">TGF-beta</span></a><span style="font-weight: 400;"> and other similar proteins, such as activin. It&rsquo;s primarily active in the ovaries but also controls skin growth and repair [</span><a href="https://www.ncbi.nlm.nih.gov/gene/10468"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087116/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18922734/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TGF-beta is a crucial protein for skin health and acne prevention. It helps prevent pore clogging &amp; excess fat production and combats acne-causing bacteria. Scientists have found lower TGF-beta activity in acne-affected skin samples [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8288915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-13-2"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24927181/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The FST gene helps produce follistatin. More follistatin = less TGF-beta = acne-prone skin.<span style="font-weight: 400;">&nbsp;</span></span></p> <p>&nbsp;</p> <h2><strong>Your FST Results for Acne</strong></h2> <p>*8169989760882708*</p> <p><a href="https://selfdecode.com/snp/rs38055/"><strong>rs38055</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.nature.com/articles/ncomms5020"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of developing acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The 'A' allele likely reduces TGF-beta activity</span></li> </ul> <p>*5567898340874211*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Acne</strong></h2> <p>*6769076368201201*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Light Therapy</strong></h4> <p><span style="font-weight: 400;">Light therapy applies light of specific wavelengths through the skin to elicit certain effects in the underlying tissue. In acne-affected skin, light therapy can reduce inflammation by boosting TGF-beta [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23992161/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16965424/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/red-light-therapy-benefits/"><span style="font-weight: 400;">Red light</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/blue-light-therapy-benefits/"><span style="font-weight: 400;">blue light</span></a><span style="font-weight: 400;">, and their combination may all help improve acne. In one study, the combination was more effective than the FDA-approved medication benzoyl peroxide [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28338214/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19239470/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6846280/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10809858/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Light therapy may improve acne by targeting your gene variant.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Limiting Dairy Intake</strong></h4> <p><span style="font-weight: 400;">Hormones and bioactive molecules found in milk can inhibit TGF-beta and contribute to skin inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507494/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Acne is absent in populations not consuming milk or dairy products [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22419445/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Two studies on adolescents have associated high intake of milk and dairy products with acne [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15692464/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391699/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Reduce your dairy intake to counteract the effects of your FST gene on acne.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Aloe Vera</strong></h4> <p><span style="font-weight: 400;">Both oral and topical application of </span><a href="https://selfhacked.com/blog/aloe-vera-benefits/"><span style="font-weight: 400;">aloe vera</span></a><span style="font-weight: 400;"> may support skin health by boosting TGF-beta [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27660884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21396624/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aloe vera helps fight bacteria, reduce inflammation, and promote wound healing when applied on the skin, making it a popular treatment for a variety of skin conditions [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2810076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19218914/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aloe components such as lupeol, salicylic acid, </span><a href="http://selfhacked.com/blog/causes-of-high-or-low-blood-urea-nitrogen-bun/"><span style="font-weight: 400;">urea</span></a><span style="font-weight: 400;">, cinnamic acid, and sulfur can all fight acne-causing bacteria [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011368/full"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A topical gel with aloe vera combined with tretinoin cream was more effective for acne than the cream alone in a clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23336746?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. </span><span style="font-weight: 400;">In another study, a topical lotion with aloe vera and clove-</span><a href="https://www.selfhacked.com/blog/basil-oil/"><span style="font-weight: 400;">basil oil</span></a><span style="font-weight: 400;"> improved acne [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S0962456203001413"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical aloe vera may improve acne by targeting your FST variant.</span></p>
386 | content_snp_table_8169989760882708_key == 8169989760882708
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386 | content_learn_more_5567898340874211_text == Based on the variant we looked at, your FST gene is associated with slightly higher odds of developing acne. However, this doesn't necessarily reflect your overall risk of acne; it’s just a genetic factor related to it. Limit your dairy intake and use aloe vera to reduce the impact of your variant. Keep scrolling to find out more.
386 | content_recommendation_6769076368201201_key == 6769076368201201
386 | content_recommendation_6769076368201201_blur == True
386 | content_recommendation_6769076368201201_hidden == False
rsIDs = rs38055
rsStatus = rs38055,,chr5,53264814,A,G,,,7,24,HET
