389 | id == 389
389 | category_id == 24
389 | category_order == 21
389 | category_name == Acne
389 | category_color == #C47AC0
389 | slug == PPARG-acne
389 | title == How a Metabolic Gene Contributes to Acne (PPARG)
389 | meta_description == The PPARG gene encodes PPAR-gamma, which may contribute to acne. Click to check your risk.
389 | summary == <p style="text-align:justify"><strong>PPAR-gamma has crucial roles in glucose and fat metabolism, but did you know it can contribute to acne? Read this post to check your PPARG gene and get personalized tips to reduce acne!</strong></p>
389 | overall_score_text == Your Acne Score (based on PPARG gene)
389 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PPARG-Acne.jpg
389 | author_id == 9
389 | author_name == Aleksa Ristic
389 | author_title == MS (Pharmacy)
389 | author_order == 45
389 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
389 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
389 | reviewer == None
389 | medical_reviewer_id == 11
389 | medical_reviewer_name == Puya Yazdi
389 | medical_reviewer_title == MD
389 | publish_date == 2020
389 | publish_date == 10
389 | publish_date == 8
389 | avg_rating == 5.0
389 | tags_id == 774
389 | tags_name == Acne
389 | tags_id == 570
389 | tags_name == Fat Metabolism
389 | tags_id == 466
389 | tags_name == PPAR-gamma
389 | tags_id == 304
389 | tags_name == PPARG gene
389 | tags_id == 776
389 | tags_name == Skin health
389 | tags_id == 793
389 | tags_name == Vitamin A
389 | permissions_favorite == False
389 | permissions_rate == False
389 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The PPARG gene helps make PPAR-gamma, which may contribute to acne development by increasing sebum production.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>One PPARG variant is associated with relatively higher PPAR-gamma activity and higher odds of developing acne.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>This post reveals a simple way to prevent and reduce acne by targeting the PPARG gene.</strong></span></p> <p>&nbsp;</p> <h2><strong>The PPARG Gene in Acne Development</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/pparg/"><span style="font-weight: 400;">PPARG</span></a><span style="font-weight: 400;"> gene helps make </span><a href="http://selfhacked.com/blog/ppargamma-role-weight-gain-inflammation-natural-activators/"><span style="font-weight: 400;">PPAR-gamma</span></a><span style="font-weight: 400;">, a protein with crucial roles in fat and </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> metabolism. When it comes to skin health, PPAR-g may contribute to acne development by increasing sebum production [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16675962/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18427822/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists are developing new treatment options for acne targeting PPAR-g, but the research in this area is still young [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28461124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your PPARG Results for Acne</strong></h2> <p>*2985074443724278*</p> <p><a href="https://selfdecode.com/snp/rs1801282/"><strong>rs1801282</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24984871/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/9806549"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with lower rates and severity of acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher rates and severity of acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele reduces PPAR-gamma activity&nbsp;</span></li> </ul> <p>*2853516550871178*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Acne</strong></h2> <p>*2458326909877288*</p> <h3><strong>Topical Vitamin A</strong></h3> <p><a href="http://selfhacked.com/blog/importance-real-vitamin-retinol/"><span style="font-weight: 400;">Vitamin A</span></a><span style="font-weight: 400;"> and its metabolites can inhibit PPAR-gamma [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18068127/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.hindawi.com/journals/ppar/2012/318613/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin A enhances skin repair and reduces inflammation and sebum production. Synthetic derivatives of vitamin A (retinoids), both oral and topical, have a central place in acne treatment [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15675886/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.aad.org/practicecenter/quality/clinical-guidelines/acne/topical-therapies"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;"><em>Synthetic retinoids are drugs, so you should not use them before consulting a healthcare professional.</em> However, topical vitamin A (retinol) is available in its pure form or as a cosmetic product ingredient.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical vitamin A may improve your skin health and reduce acne by targeting the PPARG gene.</span></p>
389 | content_snp_table_2985074443724278_key == 2985074443724278
389 | content_snp_table_2985074443724278_blur == True
389 | content_snp_table_2985074443724278_hidden == False
389 | content_learn_more_2853516550871178_key == 2853516550871178
389 | content_learn_more_2853516550871178_blur == True
389 | content_learn_more_2853516550871178_hidden == False
389 | content_learn_more_2853516550871178_text == Based on the variant we looked at, your PPARG gene is associated with relatively higher acne rates and acne severity. However, this doesn't necessarily reflect your overall risk of acne; it’s just a genetic factor related to it. Cosmetic products with vitamin A may improve acne by targeting your gene variant. Keep scrolling to find out more.
389 | content_recommendation_2458326909877288_key == 2458326909877288
389 | content_recommendation_2458326909877288_blur == True
389 | content_recommendation_2458326909877288_hidden == False
rsIDs = rs1801282
rsStatus = rs1801282,PPARG,chr3,12351626,C,G,T,,32,0,Normal
