39 | id == 39
39 | category_id == 9
39 | category_order == 6
39 | category_name == Longevity
39 | category_color == #C47AC0
39 | slug == longevity-FOXO1
39 | title == Are You Destined to Live Longer? (FOXO1)
39 | meta_description == FOXO1 repairs DNA and fights oxidative stress, but may increase diabetes risk. Should you focus on FOXO1? Find out here.
39 | summary == <p dir="ltr"><strong>FOXO1 is a double-edged sword that can repair your DNA and fight oxidative stress, but may increase your risk of diabetes. Fortunately, you may be able to keep it in balance by activating AMPK. Should you focus on FOXO1? Get personalized recommendations here.</strong></p>
39 | overall_score_text == Longevity Score (based on FOXO1)
39 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Are-You-Destined-to-Live-Longer-FOXO1_JPG.jpg
39 | author_id == 1
39 | author_name == Jasmine Foster
39 | author_title == BSc, BEd
39 | author_order == 36
39 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
39 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
39 | reviewer_id == 2
39 | reviewer_name == Joe Cohen
39 | reviewer_title == BS
39 | medical_reviewer_id == 11
39 | medical_reviewer_name == Puya Yazdi
39 | medical_reviewer_title == MD
39 | publish_date == 2019
39 | publish_date == 9
39 | publish_date == 9
39 | avg_rating == 5.0
39 | tags_id == 126
39 | tags_name == AMPK
39 | tags_id == 105
39 | tags_name == Autophagy
39 | tags_id == 127
39 | tags_name == Diabetes Type 2
39 | tags_id == 103
39 | tags_name == Forkhead Box
39 | tags_id == 125
39 | tags_name == FOXO1 Gene
39 | tags_id == 24
39 | tags_name == Inflammation
39 | tags_id == 116
39 | tags_name == Insulin Resistance
39 | tags_id == 101
39 | tags_name == Longevity
39 | tags_id == 39
39 | tags_name == Oxidative Stress
39 | permissions_favorite == False
39 | permissions_rate == False
39 | content_article == <h2><span style="font-weight: 400;">Forkhead Box O1</span></h2> <p><span style="font-weight: 400;">FOXO1 is a strange, doubled-edged little protein. It is a transcription factor, meaning that it binds to DNA and regulates the activity of other genes. More specifically, it regulates insulin production, DNA repair, cell suicide (apoptosis) and parts of the human body&rsquo;s antioxidant response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24452601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">High FOXO1 activity can be good or bad, depending on the circumstance. On the bright side, this protein [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24452601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Protects many cells from </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Suppresses the growth and metastasis of cancer cells</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Promotes DNA repair</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Improves wound healing</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Stimulates cellular recycling (</span><a href="https://selfhacked.com/blog/autophagy-benefits-and-how-to-harness/"><span style="font-weight: 400;">autophagy</span></a><span style="font-weight: 400;">) to destroy and replace damaged proteins</span></li> </ul> <p><span style="font-weight: 400;">On the other hand, FOXO1 enhances the inflammatory response and reduces </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;"> sensitivity. In fact, FOXO1 tends to be highly expressed in atherosclerotic plaques (fatty buildup in blood vessels), and mice with overactive FOXO1 tend to develop diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24452601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://cardiab.biomedcentral.com/articles/10.1186/s12933-016-0361-1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">With such a broad and complex role, it&rsquo;s not surprising that FOXO1 mutations may significantly change a person&rsquo;s health outcomes and even lifespan.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">FOXO1 protects cells from oxidative stress and promotes DNA repair, making it an important cancer suppressor gene. It also stimulates autophagy and improves wound healing, but too much FOXO1 activity may increase risk of diabetes and atherosclerosis.</span></p> <h2><span style="font-weight: 400;">Does FOXO1 Impact Longevity?</span></h2> <p><span style="font-weight: 400;">The link between FOXO1 and lifespan is controversial so far. Some studies have found that certain alleles are more common in people who live to be 100 years old or older; other studies have found no correlation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1474-9726.2011.00698.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995604/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXO1 may have more of an impact on longevity in some populations than others. In a Chinese study, for example, people with the &lsquo;C&rsquo; allele at rs2755209 and the &lsquo;T&rsquo; allele at rs2755213 were more likely to live over a century. In German and Italian studies, by contrast, there was no such link [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1474-9726.2011.00698.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some of the variation and apparent contradiction in these studies may be due in part to FOXO1&rsquo;s double-edged effects. It is possible that people with moderate FOXO1 activity (neither very high nor very low) benefit the most; no studies have yet investigated this possibility.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Some studies have found that certain FOXO1 variants are more common in people who live a very long time, but the link is controversial. People with balanced FOXO1 activity may have the most benefits.</span></p> <h2><span style="font-weight: 400;">How Might FOXO1 Make You Live Longer?</span></h2> <p><span style="font-weight: 400;">Many of FOXO1&rsquo;s core functions make it seem likely to promote longevity, while others are counter-intuitive.&nbsp;</span></p> <h3><span style="font-weight: 400;">The Bright Side: Antioxidants, DNA Repair &amp; Healing</span></h3> <p><span style="font-weight: 400;">FOXO1 activates in response to oxidative stress, promoting the expression of antioxidant genes like MnSOD (</span><a href="http://selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/"><span style="font-weight: 400;">superoxide dismutase</span></a><span style="font-weight: 400;">). Accumulated oxidative stress over time can cause progressive tissue damage and is one of the hallmarks of aging. Naturally, then, reducing oxidative stress is important for increasing lifespan [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819984/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">An improved antioxidant response is also good for wound healing. FOXO1 helps new skin cells grow and move into a wound [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXO1 promotes DNA repair and prevents cancer cells from growing and migrating throughout the body. This function&rsquo;s benefit to lifespan is clear: in 2018, 21% of all deaths in the United States were caused by cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.cdc.gov/nchs/fastats/deaths.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXO1 also stimulates autophagy, the process by which your cells recycle old and damaged proteins and re-use their parts. In animal models, increasing autophagy almost universally increases lifespan; meanwhile, people who live to be over a hundred years old are more likely to have genes that turn on or increase autophagy [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792715/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, FOXO1 has a role in maintaining stem cells, which your body uses to produce new tissues and repair damaged ones [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">The Dark Side: Inflammation &amp; Insulin Response</span></h3> <p><span style="font-weight: 400;">All of the above sounds great, so you&rsquo;d think that more FOXO1 function is better&mdash;but that&rsquo;s not necessarily the case.</span></p> <p><span style="font-weight: 400;">FOXO1 is highly expressed in atherosclerotic plaques, the fatty buildup that hardens arteries and can cause dangerous clots, heart attacks, and strokes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXO1 is also involved in the inflammatory response. </span><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-&alpha;</span></a><span style="font-weight: 400;"> stimulates FOXO1, which in turn increases the expression of inflammatory cytokines like </span><a href="http://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">. If FOXO1 remains active for a long period of time, chronic inflammation (and a serious decline in health) may result [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK493173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, in animal models, overexpressed FOXO1 in the pancreas leads to </span><a href="https://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;"> and type 2 diabetes; people with diabetes have a life expectancy 5-6 years lower than those without [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787852/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">FOXO1 is a double-edged sword that stimulates many longevity-promoting processes, but may increase inflammation, insulin resistance, and atherosclerosis.</span></p> <h3><span style="font-weight: 400;">Interactions with Other Genes</span></h3> <p><span style="font-weight: 400;">FOXO1 has many vital functions on its own, but it may only really shine in combination with other important longevity genes. For example, FOXO1 and </span><a href="http://selfhacked.com/blog/nad-and-sirt1-their-role-in-chronic-health-issues/"><span style="font-weight: 400;">SIRT1</span></a><span style="font-weight: 400;"> form a positive feedback loop: they stimulate each other&rsquo;s expression. Thus, people with naturally high FOXO1 and SIRT1 function may live longer than others [</span><a href="http://www.jbc.org/content/286/7/5289.full"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">The Big Picture: Balancing FOXO1</span></h3> <p><span style="font-weight: 400;">Ultimately, FOXO1 may do its best work when its activity is balanced: not too high and not too low. For example, FOXO1 as expressed in healthy people is beneficial to wound healing; in people with diabetes, it is destructive and may increase lesions, ulcers, and inflammatory complications [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FOXO1 can be both stimulated and suppressed by the master energy regulator, AMPK. </span><a href="http://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">AMPK</span></a><span style="font-weight: 400;"> has been shown to induce FOXO1 in healthy animals and to suppress it in animals with diabetes; thus, AMPK activity may be the key to balancing and optimizing FOXO1 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25065674"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29093682"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">AMPK, the master energy regulator, can either increase or decrease FOXO1. It may be the key to balancing FOXO1: harnessing its benefits without amplifying its drawbacks.</span></p> <h2><span style="font-weight: 400;">Your FOXO1 Results for Longevity</span></h2> <p><span style="font-weight: 400;">*9025484757619155*</span></p> <p><strong>Primary SNP: FOXO1 rs10507486</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = More common in longer-lived people (higher FOXO1 activity)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Less common in longer-lived people, decreased risk of heart disease and organ failure</span></li> </ul> <p><strong>Population frequency:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">71% of people have 'GG'</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><strong>FOXO1 rs2755209</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = More common in longer-lived people (higher FOXO1 activity)&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Less common in longer-lived people</span></li> </ul> <p><strong>Population frequency:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">34% of people have &lsquo;CC&rsquo;</span></li> </ul> <p><strong>FOXO1 rs2755213</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = More common in longer-lived people (higher FOXO1 activity)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Less common in longer-lived people</span></li> </ul> <p><strong>Population frequency:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">60% of people have 'TT'</span></li> </ul> <p>*9905705916904459*</p> <h2><span style="font-weight: 400;">Recommendations to Promote Longevity</span></h2> <p><span style="font-weight: 400;">The field of longevity research is complex and somewhat controversial. It's important to discuss any changes to your diet, exercise regime, or supplements with your doctor before you start them.</span></p> <p><span style="font-weight: 400;">*8528361557950923*</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> induces FOXO1 and its closely related cousin </span><a href="../article/longevity-foxo3-32"><span style="font-weight: 400;">FOXO3</span></a><span style="font-weight: 400;">, another transcription factor important for insulin signalling and reducing fat storage. This helps explain why people who are physically active tend to live longer! To increase FOXO1, commit to a fitness plan and focus on some forms of endurance training [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303382/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="http://selfhacked.com/blog/intermittent-fasting/"><span style="font-weight: 400;">Intermittent fasting</span></a><span style="font-weight: 400;"> and calorie restriction may also activate FOXO1 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17972158"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><a href="http://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">Substances that increase AMPK</span></a><span style="font-weight: 400;"> may be the best options for balancing FOXO1 and keeping its activity within the beneficial range. AMPK has been shown to induce FOXO1 in healthy animals and to suppress it in animals with diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25065674"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29093682"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many plant polyphenols activate AMPK; eating foods that contain them may help you balance FOXO1 and live a longer life, including:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> (red grapes, peanuts, Japanese knotweed) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;"> (leafy greens, broccoli, red onions, tea&hellip;) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;"> (</span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/top-11-science-based-health-benefits-apigenin/"><span style="font-weight: 400;">Apigenin</span></a><span style="font-weight: 400;"> (parsley, onions, oranges, tea&hellip;) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21538580"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><a href="http://selfhacked.com/blog/top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">Carnitine</span></a><span style="font-weight: 400;">, a compound found in meat and dairy, also activates AMPK and prevents insulin resistance. Fresh beef is by far the best dietary source of carnitine [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19121314"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">In cell studies, resveratrol has been shown to increase FOXO1 and the antioxidant enzyme </span><a href="http://selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/"><span style="font-weight: 400;">MnSOD</span></a><span style="font-weight: 400;"> through </span><a href="http://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">AMPK activation</span></a><span style="font-weight: 400;">. AMPK is broadly recognized as a longevity-promoting enzyme; resveratrol itself is controversial as a longevity supplement [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25065674"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27812983"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820197/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One review study found that resveratrol supplements extended the lives of about 60% of animal models; however, results varied widely from one species to another. Researchers don&rsquo;t currently agree on whether resveratrol significantly affects human lifespan. However, as it induces FOXO1 and AMPK, it may be worth a try [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27781945"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Salidroside (the active compound in </span><em><span style="font-weight: 400;">Rhodiola rosea</span></em><span style="font-weight: 400;">) also activates AMPK and down-regulates FOXO1 in diabetic mice. Thus, </span><a href="http://selfhacked.com/blog/rhodiola/"><span style="font-weight: 400;">rhodiola</span></a><span style="font-weight: 400;"> may be an especially good option for people with diabetes or prediabetic insulin resistance [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29093682"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other strong AMPK activators include bioavailable </span><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">curcumin</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For a complete list of natural AMPK activators, </span><a href="https://selfhacked.com/blog/natural-ampk-activators/"><span style="font-weight: 400;">check out this post</span></a><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Most lifestyle, diet, and supplement choices that strongly activate AMPK will be good choices to balance FOXO1 and increase lifespan. The best include exercise, fasting, resveratrol, and rhodiola.</span></p>
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39 | content_learn_more_9025484757619155_text == Based on the variants we looked at, your FOXO1 gene makes you somewhat more susceptible to age-related diseases and oxidative stress. You’ll need to activate AMPK to keep FOXO1. Keep scrolling to find out how.
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rsStatus = rs10507486,FOXO1,chr13,40612364,G,A,,,30,0,Normal
rsStatus = rs2755213,FOXO1,chr13,40572164,T,A,C,,26,0,Normal
