391 | id == 391
391 | category_id == 24
391 | category_order == 21
391 | category_name == Acne
391 | category_color == #C47AC0
391 | slug == SELL-acne
391 | title == Can Skin Inflammation Cause Acne? (SELL)
391 | meta_description == The SELL gene encodes L-selectin, which helps white blood cells migrate toward the site of inflammation. Can it cause acne?
391 | summary == <p><strong>The <em>SELL </em>gene encodes L-selectin, which helps white blood cells migrate toward the site of inflammation. Can it cause acne? Find out here.</strong></p>
391 | overall_score_text == Your Acne Score (based on SELL)
391 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SELL-Acne.jpg
391 | author_id == 1
391 | author_name == Jasmine Foster
391 | author_title == BSc, BEd
391 | author_order == 36
391 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
391 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
391 | reviewer == None
391 | medical_reviewer_id == 11
391 | medical_reviewer_name == Puya Yazdi
391 | medical_reviewer_title == MD
391 | publish_date == 2020
391 | publish_date == 10
391 | publish_date == 8
391 | avg_rating == 5.0
391 | tags_id == 774
391 | tags_name == Acne
391 | tags_id == 95
391 | tags_name == Immune System
391 | tags_id == 24
391 | tags_name == Inflammation
391 | tags_id == 796
391 | tags_name == Selectins
391 | tags_id == 795
391 | tags_name == SELL Gene
391 | tags_id == 797
391 | tags_name == Skin Inflammation
391 | permissions_favorite == False
391 | permissions_rate == False
391 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <p><em><span style="font-weight: 400;">SELL</span></em><span style="font-weight: 400;"> encodes L-selectin, which helps </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;"> move around the body. Variants of </span><em><span style="font-weight: 400;">SELL</span></em><span style="font-weight: 400;"> may play a role in acne by increasing inflammation in the skin. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by decreasing L-selectin and preventing white blood cells from migrating into the skin.</span></p> <h2><em><span style="font-weight: 400;">SELL</span></em><span style="font-weight: 400;"> and Acne</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;"><a href="https://selfdecode.com/gene/sell/" target="_blank" rel="noopener">SELL</a> </span></em><span style="font-weight: 400;">gene </span><span style="font-weight: 400;">encodes L-selectin, a protein that helps white blood cells stick to surfaces and move toward a site of inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24399259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1661630/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">White blood cells are essential for a healthy immune response, but high numbers can cause pathological inflammation. Acne, meanwhile, typically involves excessive inflammation of the skin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1661630/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810524/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17595378/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Compounds that block L-selectins are currently being tested for their potential to treat inflammatory skin conditions like psoriasis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1661630/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">L-selectin acts as a kind of &ldquo;homing beacon&rdquo; for white blood cells to enter skin tissue. Researchers suspect that&rsquo;s why one variant in the </span><em><span style="font-weight: 400;">SELL</span></em><span style="font-weight: 400;"> gene has been associated with acne [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810524/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24399259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">SELL</span></em><span style="font-weight: 400;"> gene helps white blood cells migrate into the skin, which can cause excessive inflammation and contribute to acne.</span></span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">SELL</span></em><span style="font-weight: 400;"> Results for Acne</span></h2> <p>*9586241006990936*</p> <p><strong>SELL </strong><a href="https://selfdecode.com/snp/rs7531806/"><strong>rs7531806</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = More common in people with severe acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Possibly protective against acne</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may reduce the production or activity of L-selectin, thereby decreasing the migration of white blood cells into the skin and reducing skin inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24399259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p>*1278977953517590*</p> <h2><span style="font-weight: 400;">Recommendations for Reducing Skin Inflammation</span></h2> <p>*1918509673758364*</p> <h3><span style="font-weight: 400;">Stress Management</span></h3> <p><span style="font-weight: 400;">Psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> may increase the production of L-selectin and, therefore, increase </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cell</span></a><span style="font-weight: 400;"> migration into the skin [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12715014/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Studies in adolescents and young adults have associated </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> with increased acne severity, especially in males [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17340019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12873885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a small clinical trial, a relaxation therapy combining biofeedback and cognitive imagery helped improve acne [</span><a href="https://pubmed.ncbi.nlm.nih.gov/6224928/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The hormones released during stress are believed to increase both fat production and inflammation in the skin. Stress may also slow the repair of acne wounds [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9828880/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124543/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10232300/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">We recommend addressing sources of stress in your life, either by taking up a stress-busting hobby (such as </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> or </span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;">meditation</span></a><span style="font-weight: 400;">) or seeking professional help.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Psychological stress may increase L-selectin and promote the development of acne.</span></p> <h3><span style="font-weight: 400;">Fish Oil</span></h3> <p><span style="font-weight: 400;">DHA</span><span style="font-weight: 400;">, an </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acid abundant in fatty fish, appears to reduce L-selectins and prevents white blood cell migration [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8970622/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781310/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The omega-3 fatty acids in </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> (</span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">DHA</span></a><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;"> and </span></a><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">EPA</span></a><span style="font-weight: 400;">) are well-studied anti-inflammatory compounds, and they may help with acne-associated skin inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10617994/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Several studies have associated higher dietary intake of fish and seafood, both rich in </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acids, with lower incidence and severity of acne [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20822969/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22386050/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037798/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fatty fish such as mackerel, salmon, sardines, and herrings are especially rich in omega-3 fatty acids [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22122770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fish oil supplementation improved overall acne severity in two clinical trials and a few case studies, especially for those with moderate-to-severe acne [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543297/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24553997/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577647/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">DHA from fish oil may reduce L-selectin activity, decrease inflammation, and improve acne.</span></p>
391 | content_snp_table_9586241006990936_key == 9586241006990936
391 | content_snp_table_9586241006990936_blur == True
391 | content_snp_table_9586241006990936_hidden == False
391 | content_learn_more_1278977953517590_key == 1278977953517590
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391 | content_learn_more_1278977953517590_text == Based on the variants we looked at, your SELL gene is somewhat associated with acne. However, this doesn't necessarily reflect your overall risk of acne; it’s just one gene related to it. Stress management and fish oil may help. Keep scrolling to find out more.
391 | content_recommendation_1918509673758364_key == 1918509673758364
391 | content_recommendation_1918509673758364_blur == True
391 | content_recommendation_1918509673758364_hidden == False
rsIDs = rs7531806
rsStatus = rs7531806,LOC107985745,chr1,169681903,G,A,,,5,21,HET
