394 | id == 394
394 | category_id == 24
394 | category_order == 21
394 | category_name == Acne
394 | category_color == #C47AC0
394 | slug == il17-acne
394 | title == What role does this cytokine family play in acne? (IL-17A and IL-17F)
394 | meta_description == Variants of IL-17A and IL-17F are associated with acne. Click here for some diet and gene-based tips!
394 | summary == <p style="text-align:justify">The genes IL-17A and IL-17F play similar roles in inflammation, are produced by Th17 cells and are associated with acne. Read on to find out how we can target Th17 cells in order to help improve acne symptoms.</p>
394 | overall_score_text == Your Acne Score (based on IL-17A and IL-17F genes)
394 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL-17-Acne.jpg
394 | author_id == 15
394 | author_name == John Williams
394 | author_title == B.Sc
394 | author_order == 3987
394 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/sinan_pic.png
394 | author_intro == <p>John received his BSc from the University of Toronto.&nbsp;John has spent the last several years teaching high school science and math to English-language learners, which has forced him to learn how to simplify difficult concepts as much as possible. He has also worked in two different research labs and has experience as a student intern working and studying under doctors in hospitals and clinics to help diagnose and treat patients, interpret lab results and fill out mountains of paperwork.</p>
394 | reviewer == None
394 | medical_reviewer_id == 11
394 | medical_reviewer_name == Puya Yazdi
394 | medical_reviewer_title == MD
394 | publish_date == 2020
394 | publish_date == 10
394 | publish_date == 9
394 | avg_rating == 5.0
394 | tags_id == 774
394 | tags_name == Acne
394 | tags_id == 349
394 | tags_name == IL17A gene
394 | tags_id == 24
394 | tags_name == Inflammation
394 | tags_id == 440
394 | tags_name == Th17 Cells
394 | permissions_favorite == False
394 | permissions_rate == False
394 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">IL-17A</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">IL-17F</span></em><span style="font-weight: 400;"> encode proteins that play a role in inflammation.</span> <span style="font-weight: 400;">Variants of these genes</span> <span style="font-weight: 400;">may play a role in acne by producing more </span><em><span style="font-weight: 400;">IL-17A</span></em><span style="font-weight: 400;"> or </span><em><span style="font-weight: 400;">IL-17F</span></em><span style="font-weight: 400;">, leading to affected areas appearing bigger, redder and hotter. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by preventing Th-17 cells from making IL-17A and IL-17F in the first place.</span></span></p> <h2 style="text-align: justify;"><strong><em>IL-17</em> and Acne</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">IL-17 is a family of immune cells called &ldquo;cytokines&rdquo; that play a role in inflammation and cause skin cells to multiply. This article will focus on two members of this family: IL-17A and IL-17F. While they function in a similar manner, IL-17F produces less inflammation than IL-17A. This is because IL-17A recruits many other cells that will increase inflammation whereas IL-17F only recruits a few such cells [</span><a href="https://www.mdpi.com/1420-3049/25/9/2154/htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663007/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.cell.com/immunity/pdf/S1074-7613(08)00557-8.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Th-17 cells make both IL-17A and IL-17F as well as other cytokines that cause inflammation. The bacteria responsible for causing acne activates this process. As a result, high IL-17 levels are associated with acne and result in affected areas feeling bigger, redder and hotter than the surrounding skin [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23924903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30070012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your <em>IL-17</em> Results for Acne</strong></h2> <p style="text-align: justify;">*3525773191292791*&nbsp;</p> <p style="text-align: justify;"><strong>Primary SNP: </strong><strong><em>IL17A </em></strong><a href="https://selfdecode.com/snp/rs2275913/"><strong>rs2275913</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with increased IL-17A levels; associated with increased inflammation</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = no association with IL-17A levels</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Inflammation, one of the symptoms of acne, is higher in &lsquo;A&rsquo; variants because they produce more IL-17A. While the &lsquo;AA&rsquo; variant only occurs in 12% of the general population, it is particularly uncommon in populations from Africa with only 0.3% of people having that genotype [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30233234/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><strong>Other Important SNPs: </strong><strong><em>IL17F </em></strong><a href="https://selfdecode.com/snp/rs763780/"><strong>rs763780</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with increased IL-17F levels; associated with increased inflammation&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = no association with IL-17F levels</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Inflammation, one of the symptoms of acne, is higher in &lsquo;T&rsquo; variants because they produce more IL-17F. The &lsquo;C&rsquo; variant is quite uncommon, occurring in only 9% of the population [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22312940/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;">*7993639239465415*&nbsp;</p> <h2 style="text-align: justify;"><strong>Recommendations for Improving Acne</strong></h2> <p style="text-align: justify;">*6467185381542919*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Get more sunlight (Vitamin D)</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The sebaceous glands, which are plugged in acne vulgaris, have a large number of </span><a href="https://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> receptors. Vitamin D levels seem to be inversely related to acne; that is, if your Vitamin D levels are low, you are more likely to have acne and the opposite is true for high Vitamin D levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30070012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Vitamin D3, which can be obtained from sunlight or animal products, reduces the activity of the IL17 pathway by preventing the bacteria </span><em><span style="font-weight: 400;">P. acnes</span></em><span style="font-weight: 400;"> from activating Th17 cells. This prevents IL-17A and IL-17F from being released and results in reduced inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23924903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A study found that taking Vitamin D for acne saw a 75 to 80 percent improvement in acne symptoms. That same study also found that, once Vitamin D was stopped, the acne returned within 10 days only 10% of the time [</span><a href="https://jamanetwork.com/journals/jamadermatology/article-abstract/519478"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Vitamin D found in sunlight may help with acne.</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Increase Vitamin A</strong></h4> <p style="text-align: justify;"><a href="https://selfhack.com/blog/importance-real-vitamin-retinol/"><span style="font-weight: 400;">Vitamin A</span></a><span style="font-weight: 400;"> works on acne by preventing </span><em><span style="font-weight: 400;">P. acnes</span></em><span style="font-weight: 400;"> from activating Th17 cells, thus reducing the inflammation caused by IL-17A and IL-17F [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23924903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Dietary Vitamin A comes in two forms: preformed and provitamin A. Preformed Vitamin A comes from sources like liver and can actually cause harm if you ingest too much of it. That's why we suggest adding more provitamin A to your diet. Provitamin A is turned into Vitamin A inside of your body and can be obtained by eating green leafy vegetables, carrots and sweet potatoes [</span><a href="https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Add more Vitamin A to your diet by eating green leafy vegetables, carrots or sweet potatoes.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Zinc</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">The IGF-1 pathway causes certain kinds of skin cells to increase in number in acne. </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">Zinc</span></a><span style="font-weight: 400;"> is able to counteract the IGF-1 pathway in order to reduce production of these cells. Zinc has also been found to reduce IL-17 levels in other inflammatory diseases, such as hepatitis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20927124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26504859/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Applying zinc ointment to your skin has been found to be helpful in mild to moderate cases of acne [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19082228/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">When taken together, this information suggests a possible role for zinc in improving acne symptoms by reducing IL-17 related inflammation.</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Consider supplementing with zinc as it may help reduce acne-related symptoms.</span></p>
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394 | content_learn_more_7993639239465415_text == Based on the variants we looked at, your IL-17 genes make you somewhat more likely to develop acne. However, this doesn't necessarily reflect your overall risk of acne; it’s just one gene related to it. Vitamin A, Vitamin D, and zinc may help. Keep scrolling to find out more.
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394 | content_recommendation_6467185381542919_blur == True
394 | content_recommendation_6467185381542919_hidden == False
rsIDs = rs763780,rs2275913
rsStatus = rs763780,IL17F,chr6,52236941,T,C,,,30,0,Normal
rsStatus = rs2275913,IL17A,chr6,52186235,G,A,C,,31,0,Normal
