398 | id == 398
398 | category_id == 25
398 | category_order == 22
398 | category_name == Blood Sugar
398 | category_color == #C47AC0
398 | slug == ADCY5-blood-sugar
398 | title == An Enzyme Linking Insulin Release and Elevated Blood Sugar (ADCY5)
398 | meta_description == ADCY5 is involved in insulin release. Variants of ADCY5 have been associated with elevated blood sugar. Read more here.
398 | summary == <p style="text-align:justify"><strong>The <em>ADCY5</em> gene codes for adenylate cyclase 5, an enzyme that converts the energy-carrying compound ATP to the energy-independent compound cAMP. cAMP is required for energy-independent processes involved in the release of insulin, a hormone that regulates blood sugar levels. Variants of <em>ADCY5</em> have been associated with elevated blood sugar while fasting. Read more to learn about this association, and to learn about recommendations you may follow to mitigate the negative effects of these variants.</strong></p>
398 | overall_score_text == Your Blood Sugar Score (based on ADCY5 gene)
398 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ADCY5-Blood-Sugar-Diabetes.jpg
398 | author_id == 14
398 | author_name == Shany Lahan
398 | author_title == MS (Neuroscience)
398 | author_order == 5
398 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
398 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
398 | reviewer == None
398 | medical_reviewer_id == 11
398 | medical_reviewer_name == Puya Yazdi
398 | medical_reviewer_title == MD
398 | publish_date == 2020
398 | publish_date == 10
398 | publish_date == 9
398 | avg_rating == 5.0
398 | tags_id == 802
398 | tags_name == ADCY5 Gene
398 | tags_id == 804
398 | tags_name == Adenylate Cyclase
398 | tags_id == 803
398 | tags_name == ATP
398 | tags_id == 801
398 | tags_name == Blood Sugar
398 | tags_id == 45
398 | tags_name == cAMP
398 | tags_id == 139
398 | tags_name == Insulin
398 | tags_id == 805
398 | tags_name == Pancreas
398 | permissions_favorite == False
398 | permissions_rate == False
398 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ADCY5 </span></em><span style="font-weight: 400;">gene codes for adenylate cyclase 5, an enzyme involved in the release of a hormone that regulates blood sugar levels. Variants of </span><em><span style="font-weight: 400;">ADCY5 </span></em><span style="font-weight: 400;">may play a role in elevated blood sugar levels by lowering production of adenylate cyclase 5. Diet and supplement modifications may counteract the effects of these variants by increasing the activity of adenylate cyclase 5.</span></span></p> <h2 style="text-align: justify;"><strong><em>ADCY5</em> and Blood Sugar</strong></h2> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">Insulin</span></a><span style="font-weight: 400;"> is a hormone that promotes the storage of </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">blood sugar</span></a><span style="font-weight: 400;"> in muscle, fat, and the liver, thereby lowering levels of this sugar in the blood. Insulin is usually released from cells of the pancreas in response to elevated blood sugar levels; for example, after consumption of a meal [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The release of insulin from pancreatic cells is both energy-dependent and -independent. ATP is a compound that enables the energy-dependent processes of insulin release to occur within pancreatic cells. Interestingly, blood sugar can increase ATP production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In order for the energy-independent processes to occur, ATP must be converted to a compound called cAMP. The </span><a href="https://selfdecode.com/gene/adcy5/"><em><span style="font-weight: 400;">ADCY5 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for adenylate cyclase 5, an enzyme that converts ATP to cAMP. Adenylate cyclase 5 is therefore essential to the release of insulin and further, to the reduction of blood sugar levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://medlineplus.gov/genetics/gene/adcy5/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">ADCY5 </span></em><span style="font-weight: 400;">have been associated with </span><a href="https://selfhacked.com/blog/fasting-blood-glucose-test/"><span style="font-weight: 400;">elevated blood sugar during periods of fasting</span></a><span style="font-weight: 400;"> (i.e., no consumption of food or drinks). Not surprisingly, these variants have also been associated with an increased risk of </span><a href="https://selfhacked.com/blog/glucose/#What_Is_Diabetes"><span style="font-weight: 400;">type 2 diabetes</span></a><span style="font-weight: 400;">. Studies have shown that these variants may lower production of adenylate cyclase 5, leading to decreased insulin release and elevated blood sugar levels while fasting [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28684635/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2 style="text-align: justify;"><strong>Your <em>ADCY5</em> Results for Blood Sugar</strong></h2> <p style="text-align: justify;">*8808814610020357*</p> <p style="text-align: justify;"><strong>Primary SNP: </strong><strong><em>ADCY5 </em></strong><a href="https://selfdecode.com/snp/rs11708067/"><strong>rs11708067</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of elevated blood sugar while fasting</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with blood sugar</span></li> </ul> <p style="text-align: justify;"><strong>Other Important SNPs: </strong><strong><em>ADCY5 </em></strong><a href="https://selfdecode.com/snp/rs11717195/"><strong>rs11717195</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of elevated blood sugar while fasting</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with blood sugar</span></li> </ul> <p style="text-align: justify;">*6811667847894407*</p> <h2 style="text-align: left;"><strong>Recommendations for Lowering Blood Sugar</strong></h2> <p style="text-align: justify;">*4219457026423365*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Magnesium-Rich Foods</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">Magnesium</span></a><span style="font-weight: 400;"> is a mineral required for the activity of various forms of adenylate cyclase, including adenylate cyclase 5 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/6259515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple studies of diabetic and non-diabetic individuals have shown that magnesium can increase the release of insulin and in turn, decrease levels of blood sugar while fasting [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21205110/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219896/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28526383/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, low magnesium intake has previously been associated with an increased risk of type 2 diabetes, while high magnesium intake has been associated with a decreased risk [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23217601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336527/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Indeed, increased consumption of magnesium-rich foods, such as pumpkin seeds, almonds, and spinach, has been suggested to lower the risk of type 2 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17645588"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://my.clevelandclinic.org/health/articles/15650-magnesium-rich-food"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">A magnesium-rich diet may decrease fasting blood sugar levels and reduce the risk of type 2 diabetes by increasing the activity of adenylate cyclase 5 and stimulating the release of insulin.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Forskolin&nbsp;</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/health-benefits-of-forskolin/"><span style="font-weight: 400;">Forskolin</span></a><span style="font-weight: 400;"> is a compound obtained from the dried root of </span><em><span style="font-weight: 400;">Coleus barbatus</span></em><span style="font-weight: 400;">, a perennial in the mint family.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Forskolin is commonly used by researchers to increase the activity of adenylate cyclase 5 (as well as other forms of adenylate cyclase), suggesting that it can stimulate insulin release [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC319568/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a study of healthy and diabetic rats, treatment with forskolin was observed to significantly decrease levels of blood sugar while fasting [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970096/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Forskolin supplements may decrease fasting blood sugar levels by increasing the activity of adenylate cyclase 5 and stimulating the release of insulin.</span></p>
398 | content_snp_table_8808814610020357_key == 8808814610020357
398 | content_snp_table_8808814610020357_blur == True
398 | content_snp_table_8808814610020357_hidden == False
398 | content_learn_more_6811667847894407_key == 6811667847894407
398 | content_learn_more_6811667847894407_blur == True
398 | content_learn_more_6811667847894407_hidden == False
398 | content_learn_more_6811667847894407_text == Based on the variants we looked at, your ADCY5 gene may somewhat increase your risk of elevated blood sugar while fasting. However, this doesn't necessarily reflect your overall risk of elevated fasting blood sugar; it’s just one gene related to it. A magnesium-rich diet and forskolin supplements may help. Keep scrolling to find out more.
398 | content_recommendation_4219457026423365_key == 4219457026423365
398 | content_recommendation_4219457026423365_blur == True
398 | content_recommendation_4219457026423365_hidden == False
rsIDs = rs11708067,rs11717195
rsStatus = rs11708067,ADCY5,chr3,123346931,A,G,,,42,0,Normal
rsStatus = rs11717195,ADCY5,chr3,123363551,T,C,,,27,0,Normal
