401 | id == 401
401 | category_id == 25
401 | category_order == 22
401 | category_name == Blood Sugar
401 | category_color == #C47AC0
401 | slug == CDKAL1-blood-sugar
401 | title == Does This Insulin Control Gene Protect Against Diabetes? (CDKAL1)
401 | meta_description == CDKAL1 encodes a protein that controls insulin release. Do you have variants that may lead to insulin resistance & diabetes?
401 | summary == <p><strong><em>CDKAL1 </em>encodes a protein that controls insulin release. Do you have the variants that may lead to insulin resistance &amp; diabetes? Find out here.</strong></p>
401 | overall_score_text == Your Blood Sugar Score (based on CDKAL1)
401 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CDKAL1-Blood-Sugar-Diabetes.jpg
401 | author_id == 1
401 | author_name == Jasmine Foster
401 | author_title == BSc, BEd
401 | author_order == 36
401 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
401 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
401 | reviewer == None
401 | medical_reviewer_id == 11
401 | medical_reviewer_name == Puya Yazdi
401 | medical_reviewer_title == MD
401 | publish_date == 2020
401 | publish_date == 10
401 | publish_date == 12
401 | avg_rating == 5.0
401 | tags_id == 801
401 | tags_name == Blood Sugar
401 | tags_id == 811
401 | tags_name == CDKAL1 Gene
401 | tags_id == 127
401 | tags_name == Diabetes Type 2
401 | tags_id == 139
401 | tags_name == Insulin
401 | tags_id == 116
401 | tags_name == Insulin Resistance
401 | permissions_favorite == False
401 | permissions_rate == False
401 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <p><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> encodes Cdk5, a protein that controls insulin secretion. Variants of </span><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> may play a role in diabetes by promoting insulin resistance. Lifestyle, diet, and supplement modifications may counteract the effect of these variants by increasing insulin sensitivity.</span></p> <h2><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> and Blood Sugar</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> gene encodes Cdk5, a protein that is fairly well-studied for its association with type 2 diabetes [</span><a href="https://www.nature.com/articles/srep03131"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.sciencedirect.com/science/article/pii/S2212877817304532"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cdk5 is a messenger protein with multiple functions, including the inhibition of </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;"> production in the pancreas [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16155576"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16887799/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11882646/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to one study, when Cdk5 is blocked, insulin secretion is increased in cells exposed to high glucose. That is to say, Cdk5 may keep insulin levels from getting too high in response to sugars [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16155576/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cdk5 is highly expressed in the muscles, brain, and pancreas. The Cdk5 protein activates the expression of the proinsulin gene and mice lacking Cdk5 had reduced insulin production and secretion in response to </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;">. In line with this, Cdk5 variants have been associated with reduced pancreatic function and higher diabetes risk [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067665/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516729/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000340/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21908934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17804762/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20568056/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Based on the general mechanism of the protein, we can speculate that variants associated with diabetes have reduced Cdk5 activity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18264689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26119585/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> encodes a messenger protein that blocks insulin production. Variants that reduce the expression of this gene are associated with insulin resistance and diabetes.</span></span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> Results for Blood Sugar</span></h2> <p>*1060954494901684*</p> <p><strong>CDKAL1 </strong><a href="https://selfdecode.com/snp/rs7756992/"><strong>rs7756992</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with abnormal blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with high blood sugar and type 2 diabetes risk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may reduce Cdk5, allowing uncontrolled insulin production and leading to insulin resistance, reduced pancreatic function, and diabetes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/22885922"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29358691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This SNP has also been associated with decreased overall metabolic rate and high blood pressure [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/22885922"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29358691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>CDKAL1 </strong><a href="https://selfdecode.com/snp/rs10440833/"><strong>rs10440833</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with abnormal blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with high blood sugar and type 2 diabetes risk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele may reduce Cdk5, allowing uncontrolled insulin production and leading to insulin resistance, reduced pancreatic function, and diabetes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30718926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>CDKAL1 </strong><a href="https://selfdecode.com/snp/rs7754840/"><strong>rs7754840</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with abnormal blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with high blood sugar and type 2 diabetes risk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may reduce Cdk5, allowing uncontrolled insulin production and leading to insulin resistance, reduced pancreatic function, and diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18477659"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*4203060634610751*</p> <h2><span style="font-weight: 400;">Recommendations for Controlling Blood Sugar</span></h2> <p>*9294616548094308*</p> <h3><span style="font-weight: 400;">Caffeine</span></h3> <p><span style="font-weight: 400;">Caffeine has been found to interact with the </span><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> gene in determining susceptibility to diabetes. However, one study only found a benefit for caffeine in people with at least one &lsquo;G&rsquo; allele at rs7754840, so caffeine may only help if you&rsquo;re heterozygous (the &lsquo;CG&rsquo; genotype) for the harmful allele [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25755232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Moderate coffee consumption has been associated with a reduced incidence of type 2 diabetes in multiple studies, especially in younger and middle-aged women. Both chlorogenic acids and </span><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">caffeine</span></a><span style="font-weight: 400;"> seem to account for this protective effect [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16443894/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24150256/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27026242/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30352712/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28826374/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Studies show that long-term coffee consumption reduces sugar spikes and increases insulin sensitivity, leading to better blood glucose control [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Caffeine may work with the </span><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> gene to determine susceptibility to diabetes. People who are heterozygous for (i.e. only have one copy of) certain risk alleles may benefit the most from caffeine.</span></span></p> <h3><span style="font-weight: 400;">Healthy Weight</span></h3> <p><span style="font-weight: 400;">Detrimental </span><em><span style="font-weight: 400;">CDKAL1 </span></em><span style="font-weight: 400;">variants are believed to contribute to diabetes through the development of insulin resistance. </span><em><span style="font-weight: 400;">CDKAL1 </span></em><span style="font-weight: 400;">variants also have a complex relationship with body weight and may increase belly fat in some populations, so it&rsquo;s especially important to keep your weight within the ideal range [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16155576/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796390/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Being overweight or obese is the number one risk factor for high blood sugar levels, </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">, and type 2 diabetes. Even a slight weight reduction can be beneficial [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857968/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829255/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The single most important thing that can help you </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">lose weight</span></a><span style="font-weight: 400;"> is to consume fewer calories. Multiple studies show the effectiveness of calorie restriction in lowering blood glucose and insulin resistance [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10102702/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686951/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">To learn about the best ways to reach and maintain a healthy weight based on your DNA, check out our </span><a href="https://get.selfdecode.com/weight/"><span style="font-weight: 400;">Body Weight DNA Wellness Report</span></a><span style="font-weight: 400;">.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">CDKAL1</span></em><span style="font-weight: 400;"> variants are believed to contribute to diabetes through insulin resistance, and the best way to increase insulin sensitivity is to maintain a healthy weight.</span></span></p>
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401 | content_learn_more_4203060634610751_text == Based on the variants we looked at, your CDKAL1 gene is somewhat associated with diabetes. However, this doesn't necessarily reflect your overall risk of diabetes; it’s just one gene related to it. Caffeine and weight management may help. Keep scrolling to find out more.
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rsIDs = rs7756992,rs7754840,rs10440833
rsStatus = rs7756992,CDKAL1,chr6,20679478,A,G,T,,10,12,HET
rsStatus = rs7754840,CDKAL1,chr6,20661019,G,A,C,T,23,0,Normal
rsStatus = rs10440833,CDKAL1,chr6,20687890,T,A,G,,18,13,HET
