405 | id == 405
405 | category_id == 25
405 | category_order == 22
405 | category_name == Blood Sugar
405 | category_color == #C47AC0
405 | slug == CDKN2B-blood-sugar
405 | title == A Gene That Controls Insulin-Producing Cells (CDKN2B)
405 | meta_description == CDKN2B controls the growth of beta cells in the pancreas. How is it connected to insulin resistance and diabetes?
405 | summary == <p><strong><em>CDKN2B </em>controls the growth of beta cells in the pancreas. How is it connected to insulin resistance and diabetes? Read on to find out.</strong></p>
405 | overall_score_text == Your Blood Sugar Score (based on CDKN2B)
405 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CDKN2B-Blood-Sugar-Diabetes.jpg
405 | author_id == 1
405 | author_name == Jasmine Foster
405 | author_title == BSc, BEd
405 | author_order == 36
405 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
405 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
405 | reviewer == None
405 | medical_reviewer_id == 11
405 | medical_reviewer_name == Puya Yazdi
405 | medical_reviewer_title == MD
405 | publish_date == 2020
405 | publish_date == 10
405 | publish_date == 13
405 | avg_rating == 5.0
405 | tags_id == 801
405 | tags_name == Blood Sugar
405 | tags_id == 192
405 | tags_name == Cardiovascular Disease
405 | tags_id == 815
405 | tags_name == CDKN2B Gene
405 | tags_id == 127
405 | tags_name == Diabetes Type 2
405 | tags_id == 139
405 | tags_name == Insulin
405 | tags_id == 116
405 | tags_name == Insulin Resistance
405 | permissions_favorite == False
405 | permissions_rate == False
405 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <p><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> encodes a protein that stops runaway cell growth and division. Variants of </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> may play a role in high blood sugar by regulating the growth of cells that produce insulin. Lifestyle and supplement modifications may counteract the effects of these variants by increasing </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> and preventing insulin levels from getting too high.</span></p> <h2><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> and Blood Sugar</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">CDKN2B </span></em><span style="font-weight: 400;">gene encodes cyclin-dependent kinase 4 inhibitor B, also known as multiple tumor suppressor 2 (MTS-2). Mutations in and around this gene are very common in multiple types of tumors [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1030"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> gene expression is dramatically increased by </span><a href="http://selfhacked.com/blog/tgf/"><span style="font-weight: 400;">TGF-beta</span></a><span style="font-weight: 400;"> (transforming growth factor beta), which has a wide variety of functions including to block the growth and development of some types of cells [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1030"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene/7040"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://medlineplus.gov/genetics/gene/tgfbr1/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the pancreas, </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> appears to influence the growth and development of beta cells, the type of cell responsible for making </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;">. Some researchers believe that this beta cell activity is directly responsible for </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;">&rsquo;s association with type 2 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More specifically, </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> puts the brakes on beta cell growth, meaning that this gene&rsquo;s function is to reduce insulin production. When insulin is too high, the body can become resistant to its effects, eventually leading to diabetes. Thus, high expression of </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> is generally preferable to low expression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, the link between </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> and diabetes may only exist in certain populations. For example, a study of ethnic Arabs living in Saudi Arabia found no association between </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> variants and type 2 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257888/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have found far-reaching associations of </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> variants with related conditions, including [</span><a href="https://europepmc.org/abstract/med/21378990"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29212778"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/28887542"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Heart attacks</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Heart disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Atherosclerosis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Coronary artery disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">High cholesterol</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> helps keep the growth of insulin-producing beta cells from getting out of control. Variants in this gene may lead to overproduction of insulin and high blood sugar.</span></span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> Results for Blood Sugar</span></h2> <p>*3571857005125356*</p> <p><strong>CDKN2B </strong><a href="https://selfdecode.com/snp/rs1063192/"><strong>rs1063192</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively higher blood sugar and incidence of diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively lower blood sugar and incidence of diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele may increase </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> expression, leading to reduced insulin production</span></li> </ul> <p><strong>CDKN2B </strong><a href="https://selfdecode.com/snp/rs10811661/"><strong>rs10811661</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with higher blood sugar in physically fit people</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with higher blood sugar in physically inactive people and lower blood sugar in physically fit people</span></li> </ul> <p>*9257371624909371*</p> <h2><span style="font-weight: 400;">Recommendations for Controlling Blood Sugar</span></h2> <p>*6654283456186460*</p> <h3><span style="font-weight: 400;">Exercise</span></h3> <p><span style="font-weight: 400;">People with the &lsquo;C&rsquo; allele at rs10811661 experienced a far greater benefit to blood sugar when they exercised than people without the &lsquo;C&rsquo; allele. In fact, in people who are physically fit, the &lsquo;C&rsquo; allele may be mildly protective against diabetes, compared to the &lsquo;T&rsquo; allele [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682680/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Exercise is beneficial for blood sugar control regardless of your DNA, but people with the &lsquo;C&rsquo; allele of rs10811661 should take special care to stay fit.</span></p> <p><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Physical activity</span></a><span style="font-weight: 400;"> is a great way to manage blood </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> levels, being its effectiveness higher with increased intensity and duration. Muscle activity burns glucose for energy and makes cells more sensitive to insulin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781559/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587394/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26853238/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510106/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30553010/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise is especially beneficial for blood sugar control in people with the &lsquo;C&rsquo; allele of rs10811661.</span></p> <h3><span style="font-weight: 400;">Curcumin</span></h3> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;">, an active compound found in turmeric, may trigger programmed cell death in damaged cells by increasing </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> expression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509453/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple animal studies and preliminary clinical research have found that curcumin can lower blood sugar levels, decrease </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">, improve the function of pancreatic cells, suppress the death of these cells, and ultimately prevent the development of diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857752/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723242/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Curcumin may increase </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> expression, lower blood sugar, and improve the function of the pancreas.</span></span></p> <h3><span style="font-weight: 400;">Ginseng</span></h3> <p><span style="font-weight: 400;">Active compounds from Korean ginseng have been found to increase the expression of the </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> gene as well as many other genes responsible for tumor prevention [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126342/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A review of 16 studies determined that </span><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginseng</span></a><span style="font-weight: 400;"> slightly reduced </span><a href="http://selfhacked.com/blog/intermittent-fasting/"><span style="font-weight: 400;">fasting</span></a><span style="font-weight: 400;"> blood </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> but pointed out that the different ginseng types may differ in their effectiveness, making it necessary to conduct more clinical studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180277/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781779/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In healthy people, both American and Korean ginseng lowered blood glucose levels. However, a review of 2 studies determined that consistent ginseng consumption had no effect on blood sugar control in healthy individuals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11194526/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21619921"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15982990"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19017419"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In people with type 2 diabetes, Korean red ginseng also had mixed results: it lowered blood sugar, insulin resistance, and glycated </span><a href="https://selfhacked.com/blog/hemoglobin-good-bad-lab-tests-normal-values-reference-ranges/"><span style="font-weight: 400;">hemoglobin</span></a><span style="font-weight: 400;"> in some studies while being ineffective in others [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8721940"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227112/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114517/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418337/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Ginseng extracts have been found to increase </span><em><span style="font-weight: 400;">CDKN2B</span></em><span style="font-weight: 400;"> and reduce blood sugar in some people.</span></span></p>
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405 | content_learn_more_9257371624909371_text == Based on the variants we looked at, your CDKN2B gene is somewhat associated with high blood sugar. However, this doesn't necessarily reflect your overall risk of diabetes; it’s just one gene related to it. Exercise, curcumin, and ginseng may help. Keep scrolling to find out more.
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rsIDs = rs10811661,rs1063192
rsStatus = rs10811661,,chr9,22134095,T,A,C,,30,1,HET
rsStatus = rs1063192,CDKN2B,chr9,22003368,G,A,T,,15,6,HET
