41 | id == 41
41 | category_id == 9
41 | category_order == 6
41 | category_name == Longevity
41 | category_color == #C47AC0
41 | slug == longevity-PON1
41 | title == Can This Gene Help You Live Longer? (PON1)
41 | meta_description == The PON1 gene may help you live longer, but only if you carry a certain variant. Find out where your genes stand.
41 | summary == <p><strong>What&rsquo;s the secret to a long life? Who better to study than those who live to be over 100 years old?&nbsp;Researchers did just that and found that centenarians have something in common: they tend to have a specific variant of the PON1 gene. Find out how your genes compare and what you can do to live a longer life.</strong></p>
41 | overall_score_text == Longevity Score (based on PON1 Gene)
41 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PON1_Longevity.webp
41 | author_id == 8
41 | author_name == Mathew Eng
41 | author_title == PharmD
41 | author_order == 40
41 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Mathew.jpg
41 | author_intro == <p><strong>Mathew received his PharmD from the University of Hawaii and an undergraduate degree in Biology from the University of Washington.</strong></p>    <p>Mathew is a licensed pharmacist with clinical experience in oncology, infectious disease, and diabetes management. He has a passion for personalized patient care and believes that education is essential to living a healthy life. His goal is to motivate individuals to find ways to manage their chronic conditions.</p>
41 | reviewer_id == 1
41 | reviewer_name == Jasmine Foster
41 | reviewer_title == BSc, BEd
41 | medical_reviewer_id == 11
41 | medical_reviewer_name == Puya Yazdi
41 | medical_reviewer_title == MD
41 | publish_date == 2019
41 | publish_date == 9
41 | publish_date == 12
41 | avg_rating == 5.0
41 | tags_id == 119
41 | tags_name == Detox
41 | tags_id == 134
41 | tags_name == Heart Disease
41 | tags_id == 24
41 | tags_name == Inflammation
41 | tags_id == 101
41 | tags_name == Longevity
41 | tags_id == 39
41 | tags_name == Oxidative Stress
41 | tags_id == 118
41 | tags_name == Pon1 Gene
41 | permissions_favorite == False
41 | permissions_rate == False
41 | content_article == <p><span style="font-weight: 400;"><strong>Note:</strong> PON1 is mentioned in the <a href="https://get.selfdecode.com/gene-reports/introductory/">Introductory Gene Report</a>, along with many other genes. If you're looking for a comprehensive report about your genes, check it out.</span></p> <h2><span style="font-weight: 400;">What Is The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Gene?</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene encodes a protein that is also called </span><a href="https://selfhacked.com/blog/about-pon1-and-natural-ways-to-increase-it/"><span style="font-weight: 400;">PON1</span></a><span style="font-weight: 400;">. The protein PON1, which is short for paraoxonase 1, is an enzyme that hydrolyzes (breaks apart) many different types of chemical bonds [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This ability to break down various molecules is useful for when the body needs to remove certain harmful compounds. For example, PON1 breaks apart oxidized fats that could otherwise lead to heart disease, and it can also </span><a href="https://selfhacked.com/blog/the-science-of-detoxification/"><span style="font-weight: 400;">detoxify</span></a><span style="font-weight: 400;"> toxic compounds called organophosphates [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene encodes the protein PON1, which protects the body by breaking down harmful compounds.</span></span></p> <h3><span style="font-weight: 400;">PON1&rsquo;s Effect On Lifespan</span></h3> <p><span style="font-weight: 400;">Preliminary research has revealed that certain variations in the </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene may be associated with human </span><a href="https://selfhacked.com/blog/lifestyle-diet-increase-longevity/"><span style="font-weight: 400;">longevity</span></a><span style="font-weight: 400;">. More specifically, the &ldquo;C&rdquo; allele in rs662 (also sometimes referred to as &ldquo;G&rdquo; or &ldquo;R&rdquo;) is more common in people who live extremely long compared to the other &ldquo;T&rdquo; allele [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19376276"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For example, a large analysis of 11 studies including almost 6,000 people found that </span>people over 65 years old are 16% more likely to carry the &ldquo;C&rdquo; allele. This increases to 44-69% when looking at individuals who are over 100 years old<span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19376276"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The evidence isn&rsquo;t always clear cut, however. There are other large studies that have found no connection between rs662 and longevity, so more research is needed to say for sure [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25962362"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20362697"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Some studies have found the &ldquo;C&rdquo; allele in rs662 is more common in those who live very long lives, which suggests that PON1 may influence lifespan. Other studies have found no connection, so more research is needed.&nbsp;</span></p> <h2><span style="font-weight: 400;">How Could the </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Gene Boost Longevity?</span></h2> <p><span style="font-weight: 400;">Human longevity is complex, with many factors at play, so the relationship between genes and lifespan is not always clear. Additionally, the studies are not conclusive. But if future studies did find a link between this gene and longevity, are there any good ideas on how it may boost longevity? The short answer is yes.&nbsp;</span></p> <h3><span style="font-weight: 400;">Preventing Heart Disease</span></h3> <p><span style="font-weight: 400;">The PON1 protein is able to break down oxidized fats, preventing plaque buildup in the blood vessels (also known as atherosclerosis). This means PON1 may help protect against several heart disorders such as heart failure, heart attack, and coronary artery disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A recently published, comprehensive analysis of 64 studies including over 53,000 people found that people with the &ldquo;C&rdquo; allele have lower rates of heart attacks and coronary artery disease compared to those without it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The &ldquo;C&rdquo; allele in rs662 is associated with lower rates of heart disease, which may explain how this allele could help you live longer.</span></p> <h3><span style="font-weight: 400;">Detoxing Harmful Toxins</span></h3> <p><span style="font-weight: 400;">Another important function of PON1 is eliminating toxins from the body. More specifically, PON1 breaks down organophosphates, a toxic compound commonly found in pesticides [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23590198"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Variations in rs662 can also alter the </span><a href="../article/detox-pesticides-pon1-37"><span style="font-weight: 400;">detox activity of PON1</span></a><span style="font-weight: 400;">. An analysis of 9 studies including over 2,000 people found that people who carry the &ldquo;T&rdquo; allele have higher rates of organophosphate toxicity compared to people who carry the &ldquo;C&rdquo; allele [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23590198"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This detox ability is important because those who do not properly eliminate organophosphates from their body may be at a higher risk for cancer and several neurodegenerative disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26687930"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The &ldquo;C&rdquo; allele in rs662 is linked to a lower rates of organophosphate toxicity, which may also contribute to longevity.</span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Results for Longevity</span></h2> <p>*3790645653168778*</p> <p><strong>Primary SNPs:</strong></p> <p><strong>PON1 rs662</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; = Longer than average lifespan, more likely to live past 100</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; = Less likely to live past 100</span></li> </ul> <p><span style="font-weight: 400;">Population Frequency:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">33% of the world population have &ldquo;CC&rdquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Only 7.6% of people with European ancestry have &ldquo;CC&rdquo;</span></li> </ul> <p>*6745008155795746*</p> <h2><span style="font-weight: 400;">How Can You Improve Your </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Genotype?</span></h2> <p><span style="font-weight: 400;">Longevity research is a complex and controversial field. Before trying the strategies below, talk to your doctor to find the right ones for you.</span></p> <p><span style="font-weight: 400;">*9555230067894767*</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">There are several lifestyle changes you can make to significantly boost your PON1 activity and longevity. You should try to:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Quit smoking: the oxidant compounds in cigarettes can inhibit PON1, and smoking is well-known to shorten your lifespan [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390564/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447499/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Exercise more: it activates </span><a href="http://selfhacked.com/blog/ppargamma-role-weight-gain-inflammation-natural-activators/"><span style="font-weight: 400;">PPAR-gamma</span></a><span style="font-weight: 400;">, a receptor that increases </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> expression; regular exercise by itself is also shown to decrease the risk of death [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214038/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25735253"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25180827"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23063021"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fix any inflammation issues: inflammatory compounds like </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1b</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;"> can reduce the expression of PON1 while also reducing life expectancy [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14511766"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22222492"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15915584"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26658771"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Research shows that exercising, quitting cigarettes, and reducing inflammation can significantly improve your PON1 function and possibly increase your lifespan.</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">According to research, many different types of foods can increase PON1 activity. These foods primarily work as antioxidants, which stop </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidants</span></a><span style="font-weight: 400;"> from inhibiting PON1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982418/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Foods and diets that have been shown to increase PON1 expression and possibly lifespan include:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The Mediterranean Diet potentially reduces the risk of death from any cause by 7-47% [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488773/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902736/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">Extra virgin olive oil</span></a><span style="font-weight: 400;"> has many longevity-enhancing effects, such as protecting against DNA damage, reducing the risk of heart disease, and promoting tissue regeneration [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18585720"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17879997"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">Green tea</span></a><span style="font-weight: 400;">, when consumed regularly, may reduce the risk of death from any cause [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24071782"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/blueberries-health-benefits/"><span style="font-weight: 400;">Blueberries</span></a><span style="font-weight: 400;"> were able to extend lifespan in animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413581/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/pomegranate/"><span style="font-weight: 400;">Pomegranate</span></a><span style="font-weight: 400;"> juice also extended lifespan in animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267107/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25829775"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/quercetin-23-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;">, a polyphenol found in fruits and vegetables, increases average lifespan by up to 15% in animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214562/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945814/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18692520"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">It&rsquo;s important to note that some of these findings are based on animal or cell studies. The same effect may not be seen in humans [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Foods rich in antioxidants extra virgin olive oil, green tea, and blueberries can increase the activity of PON1 and may potentially extend your lifespan.</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Antioxidant supplements can also increase the expression of PON1 and potentially enhance longevity. These include:</span></p> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/need-know-vitamin-c-32-science-based-health-benefits/"><span style="font-weight: 400;">Vitamin C</span></a><span style="font-weight: 400;"> has been shown to increase average lifespan in animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23643700"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/everything-need-know-grapeseed-extract-references/"><span style="font-weight: 400;">Grape seed extract</span></a><span style="font-weight: 400;"> reduces the risk of heart disease and cancer, potentially giving it life-enhancing effects [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21802563"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21802563"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> increases average lifespan in animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28192240"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429134/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/19-health-benefits-of-berberine-with-references/"><span style="font-weight: 400;">Berberine</span></a><span style="font-weight: 400;"> also increases average lifespan in animal studies while also having anti-aging effects on the skin [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21044622"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">Once again, many of these results are based on animal or cell studies; their effects on humans is not entirely clear [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982418/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplements that contain antioxidants like vitamin C, curcumin, and, grape seed extract may increase PON1 activity and improve longevity.</span></p>
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41 | content_learn_more_3790645653168778_text == Based on the variants we looked at, your PON1 gene makes you somewhat likely to have a longer lifespan. Exercise and antioxidant foods/supplements may help extend it even more. Keep scrolling to find out more.
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rsIDs = rs662
rsStatus = rs662,PON1,chr7,95308134,T,A,C,G,28,0,Normal
