410 | id == 410
410 | category_id == 25
410 | category_order == 22
410 | category_name == Blood Sugar
410 | category_color == #C47AC0
410 | slug == DGKB-blood-sugar
410 | title == An Enzyme with a Dual Role in Modulating Blood Sugar Levels (DGKB)
410 | meta_description == DGKB can influence blood sugar levels. Variants of this gene have been associated with elevated blood sugar. Read more here.
410 | summary == <p style="text-align:justify"><strong>The <em>DGKB </em>gene codes for an enzyme involved in the formation of phosphatidic acid. Phosphatidic acid can raise or lower blood sugar levels, depending on the cell type. Variants of <em>DGKB </em>have been associated with elevated blood sugar during periods of fasting. Read more to learn about this association, and to learn about recommendations you may follow to mitigate the negative effects of these variants.</strong><br />  &nbsp;</p>
410 | overall_score_text == Your Blood Sugar Score (based on DGKB gene)
410 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/DGKB-Blood-Sugar-Diabetes.jpg
410 | author_id == 14
410 | author_name == Shany Lahan
410 | author_title == MS (Neuroscience)
410 | author_order == 5
410 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
410 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
410 | reviewer == None
410 | medical_reviewer_id == 11
410 | medical_reviewer_name == Puya Yazdi
410 | medical_reviewer_title == MD
410 | publish_date == 2020
410 | publish_date == 10
410 | publish_date == 15
410 | avg_rating == 5.0
410 | tags_id == 821
410 | tags_name == DGKB Gene
410 | tags_id == 824
410 | tags_name == Diacylglycerol
410 | tags_id == 822
410 | tags_name == Diacylglycerol Kinase Beta
410 | tags_id == 139
410 | tags_name == Insulin
410 | tags_id == 142
410 | tags_name == Liver
410 | tags_id == 805
410 | tags_name == Pancreas
410 | tags_id == 825
410 | tags_name == Phosphatidic Acid
410 | permissions_favorite == False
410 | permissions_rate == False
410 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">DGKB </span></em><span style="font-weight: 400;">codes for diacylglycerol kinase beta, an enzyme that can influence blood sugar levels. Variants of </span><em><span style="font-weight: 400;">DGKB </span></em><span style="font-weight: 400;">may play a role in elevated blood sugar while fasting, by decreasing production of diacylglycerol kinase beta. Diet and supplement modifications may counteract the effects of these variants by modulating the body&rsquo;s response to a blood sugar-regulating hormone.</span></span></p> <h2 style="text-align: justify;"><strong><em>DGKB</em></strong><strong> and Blood Sugar</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/dgkb/"><em><span style="font-weight: 400;">DGKB </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for diacylglycerol kinase beta, an enzyme that aids in the conversion of diacylglycerol to phosphatidic acid. Diacylglycerol and phosphatidic acid are molecules that can activate proteins within cells and in turn, mediate a variety of cellular processes [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1607"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In liver cells, phosphatidic acid can increase the production of </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">blood sugar</span></a><span style="font-weight: 400;"> when levels are low. In pancreatic cells, diacylglycerol and phosphatidic acid are both necessary for the release of </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;">. Insulin is a hormone that promotes the storage of blood sugar in muscle, fat, and the liver, thereby lowering levels of this sugar in the blood [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931038/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31331711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25947912/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Phosphatidic acid can therefore increase or decrease blood sugar levels, depending on the cell type in question [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931038/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25947912/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Variants of </span><em><span style="font-weight: 400;">DGKB </span></em><span style="font-weight: 400;">have been associated with </span><a href="https://selfhacked.com/blog/fasting-blood-glucose-test/"><span style="font-weight: 400;">elevated blood sugar during periods of fasting</span></a><span style="font-weight: 400;">. These variants may decrease production of diacylglycerol kinase beta within pancreatic cells, leading to decreased conversion of diacylglycerol to phosphatidic acid and consequent reductions in insulin release [</span><a href="https://europepmc.org/abstract/med/20081858"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24035999/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25947912/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>DGKB</em></strong><strong> Results for Blood Sugar</strong></h2> <p style="text-align: justify;">*8455468765386049*</p> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Primary SNP</strong></span></p> <p style="text-align: justify;"><strong><em>DGKB </em></strong><a href="https://selfdecode.com/snp/rs2191349/"><strong>rs2191349</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of elevated blood sugar while fasting</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with elevated blood sugar while fasting</span></li> </ul> <p style="text-align: justify;"><span style="text-decoration: underline;"><strong>Other Important SNPs</strong></span></p> <p style="text-align: justify;"><strong><em>DGKB </em></strong><a href="https://selfdecode.com/snp/rs17168486/"><strong>rs17168486</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of elevated blood sugar while fasting</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with elevated blood sugar while fasting</span></li> </ul> <p style="text-align: justify;"><strong><em>DGKB </em></strong><a href="https://selfdecode.com/snp/rs2191348/"><strong>rs2191348</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of elevated blood sugar while fasting</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with elevated blood sugar while fasting&nbsp;</span></li> </ul> <p style="text-align: justify;">*8016514373667303*</p> <h2 style="text-align: left;"><strong>Recommendations for Regulating Blood Sugar</strong></h2> <p style="text-align: justify;">*7359771613094401*</p> <p style="text-align: justify;"><span style="font-weight: 400;">As phosphatidic acid can raise or lower blood sugar levels (depending on cell type), increasing production of diacylglycerol kinase beta may further elevate blood sugar levels. Therefore, individuals carrying risk variants of </span><em><span style="font-weight: 400;">DGKB </span></em><span style="font-weight: 400;">should instead focus on modulating the body&rsquo;s response to insulin, which may help regulate blood sugar levels without affecting phosphatidic acid.&nbsp;</span></p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Mediterranean Diet</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Among the Mediterranean diet&rsquo;s many health benefits, several studies have associated adherence to this diet with up to 23% lower risk of type 2 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538272/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123783/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24931280/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24744219/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In people with type 2 diabetes, the Mediterranean diet has been shown to help regulate blood sugar levels by increasing sensitivity to insulin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871653/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30070019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The Mediterranean diet states that </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> should be the main source of dietary fat. Olive oil has been shown to reduce the risk of type 2 diabetes by 16% [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436092/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/27395419"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In a clinical trial focused on overweight and diabetic individuals, olive oil consumption significantly reduced blood sugar levels while fasting [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/27344308"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In another trial focused on older adults with diabetes, an olive oil-containing diet prevented the participants from losing their eyesight [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/27541690"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet may regulate fasting blood sugar levels and protect against type 2 diabetes by modulating the body&rsquo;s response to insulin.</span></p> <h4 style="text-align: justify;"><strong>Dietary Fiber</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Fiber has been shown to delay fasting and post-meal blood sugar spikes, as well as improve </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A diet rich in sources of fiber, such as whole grains, legumes, vegetables, and fruit, has been associated with better insulin sensitivity and a reduced incidence of type 2 diabetes in multiple studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17391554/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852813/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29378044/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14747241/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26840185/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037534/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Dietary interventions replacing refined carbohydrates with fiber-rich foods significantly increased insulin sensitivity in healthy individuals and helped improve blood sugar control in those with type 2 diabetes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16567814/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20420752/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950069/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25527674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28429906/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518808/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Dietary fiber may regulate fasting and post-meal blood sugar, as well as protect against type 2 diabetes, by modulating the body&rsquo;s response to insulin.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><strong>Resistant Starch</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Multiple clinical trials have shown that supplementation with </span><a href="https://selfhacked.com/blog/reistant1-what-is-resistant-starch-sources-how-to-increase-diet/"><span style="font-weight: 400;">resistant starch</span></a><span style="font-weight: 400;"> can reduce fasting and post-meal blood sugar levels while improving insulin resistance, especially in people with type 2 diabetes and obesity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320660/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15242012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27733521/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16155268/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551340/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementation with resistant starch may prevent complications resulting from excess blood sugar in patients with type 2 diabetes. Specifically, resistant starch regulated blood sugar levels, reduced toxins released by bacteria, increased antioxidants, and protected blood vessels in individuals with this condition [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26655398/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28444346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Preliminary research on animals suggests that resistant starch may help regulate blood sugar by slowing down the uptake and digestion of carbohydrates, stimulating carbohydrate storage in the liver and muscles, and improving insulin sensitivity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21530804/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25661882/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27653386/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Resistant starch may regulate fasting and post-meal blood sugar levels by modulating the body&rsquo;s response to insulin and carbohydrates. </span></p>
410 | content_snp_table_8455468765386049_key == 8455468765386049
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410 | content_learn_more_8016514373667303_key == 8016514373667303
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410 | content_learn_more_8016514373667303_text == Based on the variants we looked at, your DGKB gene makes you somewhat more likely to have elevated blood sugar while fasting. However, this doesn't necessarily reflect your overall risk of elevated blood sugar; it’s just one gene related to it. Adhering to the Mediterranean diet, consuming more dietary fiber, and taking resistant starch supplements may help. Keep scrolling to find out more.
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rsIDs = rs2191348,rs17168486,rs2191349
rsStatus = rs2191348,,chr7,15024630,G,C,T,,36,0,Normal
rsStatus = rs17168486,DGKB,chr7,14858657,C,T,,,5,20,HET
rsStatus = rs2191349,,chr7,15024684,G,C,T,,37,0,Normal
