412 | id == 412
412 | category_id == 25
412 | category_order == 22
412 | category_name == Blood Sugar
412 | category_color == #C47AC0
412 | slug == PPARG-obesity-blood-sugar
412 | title == Double-Edged Sword in Blood Sugar Control (PPARG)
412 | meta_description == PPAR-gamma can help or hurt your blood sugar control. Click to check your PPARG variants and get tailored tips.
412 | summary == <p style="text-align:justify"><strong>Depending on your genes and other factors, PPAR-gamma can help or hurt your blood sugar control. Read this post to check your PPARG gene variants and get personalized recommendations!</strong></p>
412 | overall_score_text == Your Blood Sugar Score (based on PPARG gene)
412 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PPARG-Blood-Sugar-Diabetes.jpg
412 | author_id == 9
412 | author_name == Aleksa Ristic
412 | author_title == MS (Pharmacy)
412 | author_order == 45
412 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
412 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
412 | reviewer == None
412 | medical_reviewer_id == 11
412 | medical_reviewer_name == Puya Yazdi
412 | medical_reviewer_title == MD
412 | publish_date == 2020
412 | publish_date == 10
412 | publish_date == 15
412 | avg_rating == 5.0
412 | tags_id == 801
412 | tags_name == Blood Sugar
412 | tags_id == 127
412 | tags_name == Diabetes Type 2
412 | tags_id == 116
412 | tags_name == Insulin Resistance
412 | tags_id == 165
412 | tags_name == Obesity
412 | tags_id == 466
412 | tags_name == PPAR-gamma
412 | tags_id == 304
412 | tags_name == PPARG gene
412 | permissions_favorite == False
412 | permissions_rate == False
412 | content_article == <p>&nbsp;</p> <table style="height: 56px; width: 100%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong> The <em>PPARG</em> gene is analyzed in our <strong><a href="https://get.selfdecode.com/gene-reports/nm/fitness/">Fitness</a><em> and <a href="https://get.selfdecode.com/weight/" target="_blank" rel="noopener">Body Weight</a> DNA Wellness Reports</em></strong>, along with many other genes. If you're looking for comprehensive genetic reports on fitness and weight control, check them out!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The PPARG gene codes for PPAR-gamma, which has critical roles in glucose and fat metabolism. Increased activity of PPAR-gamma2 in fat cells may worsen insulin sensitivity.<br /><br /></strong><strong>Specific gene variants are associated with higher blood sugar levels due to increased PPAR-gamma2 activity.<br /><br /></strong><strong>This post reveals simple ways to improve blood sugar control by targeting PPARG variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>PPAR-Gamma in Glucose and Fat Metabolism</strong></h2> <p><span style="font-weight: 400;">The </span><em><a href="https://selfdecode.com/gene/pparg/"><span style="font-weight: 400;">PPARG</span></a></em><span style="font-weight: 400;"> gene codes for </span><a href="http://selfhacked.com/blog/ppargamma-role-weight-gain-inflammation-natural-activators/"><span style="font-weight: 400;">PPAR-gamma</span></a><span style="font-weight: 400;">, a protein that controls </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> and fat metabolism. Depending on the subtype and place of action, PPAR-gamma can have different metabolic effects [</span><a href="https://www.ncbi.nlm.nih.gov/gene/5468"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the liver and pancreas, PPAR-gamma1 enhances glucose metabolism and insulin sensitivity. On the other hand, excess PPAR-gamma2 activity in fat cells can accumulate fatty acids and other factors contributing to </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;"> and elevated blood sugar [</span><a href="https://diabetes.diabetesjournals.org/content/53/suppl_1/S60"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15637349"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951915/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12145143/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">PPAR-gamma1 enhances glucose metabolism in the liver and pancreas, while PPAR-gamma2 may worsen it in the fat tissue.</span></p> <p>&nbsp;</p> <h2><strong>Your PPARG Results for Blood Sugar</strong></h2> <p>*8729789629543541*</p> <p><strong>Primary SNP:</strong></p> <p><a href="https://selfdecode.com/snp/rs1801282/"><strong>rs1801282</strong></a><strong>*</strong><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/abstract/med/29358691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/22885922"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28123453/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12145143/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:&nbsp;</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher blood sugar levels and type 2 diabetes rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with lower blood sugar levels and type 2 diabetes rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele reduces PPAR-gamma2 activity in the fat tissue</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The effects of this variant are much more pronounced in obese people</span></li> </ul> <p><strong>*</strong><span style="font-weight: 400;">Some papers refer to this SNP as </span><strong>rs1805192</strong><span style="font-weight: 400;">.</span></p> <p><strong>Other Important SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs1899951/"><strong>rs1899951</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher blood sugar levels and type 2 diabetes rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with lower blood sugar levels and type 2 diabetes rates</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs17036160/"><strong>rs17036160</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/abstract/med/29358691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher blood sugar levels and type 2 diabetes rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with lower blood sugar levels and type 2 diabetes rates</span></li> </ul> <p><em><span style="font-weight: 400;">These three variants are almost always inherited together, and they act as a single genetic factor. Hence, no reason to panic if you have all red faces!&nbsp;</span></em></p> <p>*4391030861777538*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Balance Blood Sugar</strong></h2> <p>*1204282479611891*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Maintain a Healthy Weight</strong></h4> <p><span style="font-weight: 400;">As mentioned, the adverse effect of PPARG variants is much more pronounced in obese people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28123453/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Being overweight or obese is the number one risk factor for high blood sugar levels, </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">, and type 2 diabetes. Even a slight weight reduction can be beneficial [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857968/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829255/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Calorie Control</strong></h4> <p><span style="font-weight: 400;">The single most important thing that can help you </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">lose weight</span></a><span style="font-weight: 400;"> is to consume fewer calories. Multiple studies show the effectiveness of calorie restriction in lowering blood glucose and insulin resistance [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10102702/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686951/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Additionally, fasting and caloric restriction can counteract your variants by reducing PPAR-gamma2 activity in fat cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8647948/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9153284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Maintain a healthy weight with calorie control to counteract your PPARG variants and reduce blood sugar.&nbsp;&nbsp;</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Berberine</strong></h4> <p><a href="https://selfhacked.com/blog/berberine-19-health-benefits-of-berberine-with-references/"><span style="font-weight: 400;">Berberine</span></a><span style="font-weight: 400;"> can counteract your variant by reducing PPAR-gamma activity in fat cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16890192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19213344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to one meta-analysis, berberine may be beneficial in people with type 2 diabetes. However, the authors emphasized that low evidence quality [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478874/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Berberine lowered fasting and post-meal glucose and </span><a href="https://selfhacked.com/blog/factors-affecting-hba1c-how-to-optimize-hba1c-levels/"><span style="font-weight: 400;">HbA1c</span></a><span style="font-weight: 400;"> in another meta-analysis [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25498346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Berberine may reduce blood sugar levels by targeting your gene variants.</span></p>
412 | content_snp_table_8729789629543541_key == 8729789629543541
412 | content_snp_table_8729789629543541_blur == True
412 | content_snp_table_8729789629543541_hidden == False
412 | content_learn_more_4391030861777538_key == 4391030861777538
412 | content_learn_more_4391030861777538_blur == True
412 | content_learn_more_4391030861777538_hidden == False
412 | content_learn_more_4391030861777538_text == Based on the variants we looked at, your PPARG gene is associated with slightly higher blood sugar levels and diabetes rates. However, this doesn't necessarily reflect your overall risk of elevated blood sugar; it’s just one gene related to it. Maintain a healthy weight with calorie control to counteract your variants and reduce blood sugar. Keep reading to learn more.
412 | content_recommendation_1204282479611891_key == 1204282479611891
412 | content_recommendation_1204282479611891_blur == True
412 | content_recommendation_1204282479611891_hidden == False
rsIDs = rs1899951,rs1805192,rs17036160,rs1801282
rsStatus = rs1899951,PPARG,chr3,12353341,C,G,T,,31,0,Normal
rsStatus = rs1805192,PPARG,chr3,12379739,C,G,,,32,0,Normal
rsStatus = rs17036160,PPARG,chr3,12288284,C,A,T,,32,0,Normal
rsStatus = rs1801282,PPARG,chr3,12351626,C,G,T,,32,0,Normal
