413 | id == 413
413 | category_id == 25
413 | category_order == 22
413 | category_name == Blood Sugar
413 | category_color == #C47AC0
413 | slug == TLE4-diabetes-GLP
413 | title == A Surprising Genetic Factor for Insulin Resistance (TLE4)
413 | meta_description == The TLE4 gene controls insulin sensitivity. Click to learn about its link with blood glucose and get personalized tips.
413 | summary == <p style="text-align:justify"><strong>The TLE4 gene controls the activity of TCF7L2, the single most important genetic factor for diabetes. Read this post to learn how TLE4 variants correlate with blood sugar levels and what you can do about it!</strong></p>
413 | overall_score_text == Your Blood Sugar Score (based on TLE4 gene)
413 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TLE4-Blood-Sugar-Diabetes.jpg
413 | author_id == 9
413 | author_name == Aleksa Ristic
413 | author_title == MS (Pharmacy)
413 | author_order == 45
413 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
413 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
413 | reviewer == None
413 | medical_reviewer_id == 11
413 | medical_reviewer_name == Puya Yazdi
413 | medical_reviewer_title == MD
413 | publish_date == 2020
413 | publish_date == 10
413 | publish_date == 15
413 | avg_rating == 4.5
413 | tags_id == 801
413 | tags_name == Blood Sugar
413 | tags_id == 127
413 | tags_name == Diabetes Type 2
413 | tags_id == 281
413 | tags_name == GLP-1
413 | tags_id == 116
413 | tags_name == Insulin Resistance
413 | tags_id == 280
413 | tags_name == TCF7L2 gene
413 | tags_id == 832
413 | tags_name == TLE4 gene
413 | permissions_favorite == False
413 | permissions_rate == False
413 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The TLE4 gene suppresses the function of TCF7L2, a gene that controls insulin sensitivity via GLP-1 secretion.<br /><br /></strong><strong>Specific TLE4 variants correlate with increased blood sugar levels due to type 2 diabetes.<br /><br /></strong><strong>Follow our gene-based recommendations to reduce blood sugar by targeting your gene variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>How TLE4 Affects Blood Sugar</strong></h2> <p><span style="font-weight: 400;">The TLE4 gene suppresses the function of different metabolic genes. One of them is </span><a href="https://selfdecode.com/blog/article/tcf7l2-blood-sugar-404/"><span style="font-weight: 400;">TCF7L2</span></a><span style="font-weight: 400;">, a gene that controls </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin sensitivity</span></a><span style="font-weight: 400;"> via </span><a href="https://selfhacked.com/blog/glp-1-a-hormone-that-causes-weight-loss-and-good-cognitive-effects/"><span style="font-weight: 400;">GLP-1</span></a><span style="font-weight: 400;"> secretion [</span><a href="https://www.ncbi.nlm.nih.gov/gene/7091"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080658/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11266540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple TLE4 variants have been associated with type 2 diabetes, the primary cause of elevated blood sugar. These variants likely reduce GLP-1 levels, but we have yet to learn about the metabolic roles of TLE4 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30718926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29358691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080658/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your TLE4 Results for Blood Sugar</strong></h2> <p>*5815086414561386*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs17791513/"><strong>rs17791513</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30718926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher blood sugar levels due to type 2 diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely suppresses GLP-1</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs13292136/"><strong>rs13292136</strong></a><span style="font-weight: 400;"> [</span><a href="https://europepmc.org/abstract/med/22885922"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/29358691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher blood sugar levels due to type 2 diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely suppresses GLP-1</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs17791483/"><strong>rs17791483</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher blood sugar levels due to type 2 diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele likely suppresses GLP-1</span></li> </ul> <p><span style="font-weight: 400;">These three variants are almost always inherited together, so the data for only one of them is sufficient to determine your genetic risk.</span></p> <p>*4034830055654632*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Blood Sugar</strong></h2> <p>*2911558079372323*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Regular Exercise</strong></h4> <p><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> makes the body more sensitive to GLP-1, potentially lowering your genetic risk [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107470/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427815/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Physical activity is a great way to manage blood </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> levels, and it gets more effective with increased intensity and duration. Muscle activity burns glucose for energy and makes cells more sensitive to insulin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781559/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587394/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26853238/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510106/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30553010/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">The American Diabetes Association</span></em><span style="font-weight: 400;"> recommends the combination of moderate aerobic and resistance training, at least 150 min/week. It&rsquo;s also crucial to reduce the sedentary lifestyle and interrupt longer periods of sitting every 30 mins [</span><a href="https://care.diabetesjournals.org/content/39/11/2065"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise regularly to reduce the impact of TLE4 variants on blood sugar.</span></p> <h3><strong>Diet</strong></h3> <p><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">Olive oil</span></a><span style="font-weight: 400;"> may counteract your gene variants by stimulating GLP-1 secretion [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148911/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Including olive oil in a diet can reduce the risk of type 2 diabetes by 16%. Experts recommend the Mediterranean diet, which uses olive oil as its primary source of fat, to</span> <span style="font-weight: 400;">improve blood sugar control [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436092/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/27395419"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Folks praise </span><a href="http://selfhacked.com/blog/top-15-proven-scientific-reasons-spice-life-cinnamon-references/"><span style="font-weight: 400;">cinnamon</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/9-proven-health-benefits-momordica-charantia-bitter-melon-including-risks/"><span style="font-weight: 400;">bitter melon</span></a><span style="font-weight: 400;"> as age-old remedies that may reduce blood sugar, and clinical research has confirmed their effectiveness. They can also boost GLP-1 and thus lower the impact of your TLE4 gene [</span><a href="http://ajl.sagepub.com/content/early/2012/10/09/1559827612462960.full.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901047/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.hindawi.com/journals/ecam/2013/625892/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29339109"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Olive oil, cinnamon, and bitter melon may reduce blood sugar levels by targeting your gene variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Resistant Starch</strong></h4> <p><span style="font-weight: 400;">Multiple clinical trials show that supplementation with </span><a href="https://selfhacked.com/blog/reistant1-what-is-resistant-starch-sources-how-to-increase-diet/"><span style="font-weight: 400;">resistant starch</span></a><span style="font-weight: 400;"> can reduce blood glucose levels and improve </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">, especially in people with type 2 diabetes and obesity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320660/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15242012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27733521/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16155268/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551340/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Resistant starch may prevent different complications resulting from excess blood sugar, increase antioxidants, and protect the blood vessels in people with type 2 diabetes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26655398/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28444346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The beneficial metabolic effects of resistant starch partly stem from its potential to boost GLP-1, making it an excellent choice for people with TLE4 variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294823/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Resistant starch may counteract your TLE4 variants and balance blood sugar.</span></p>
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413 | content_learn_more_4034830055654632_text == Based on the variants we looked at, your TLE4 gene is associated with slightly higher blood sugar levels and diabetes rates. However, this doesn't necessarily reflect your overall risk of elevated blood sugar; it’s just one gene related to it. Exercise regularly and eat more olive oil, cinnamon & bitter melon to reduce blood sugar. Keep reading to learn more.
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rsIDs = rs17791513,rs17791483,rs13292136
rsStatus = rs17791513,,chr9,79290675,A,G,,,25,0,Normal
rsStatus = rs17791483,,chr9,79284065,A,G,,,23,0,Normal
rsStatus = rs13292136,,chr9,79337213,C,A,G,T,48,0,Normal
