415 | id == 415
415 | category_id == 25
415 | category_order == 22
415 | category_name == Blood Sugar
415 | category_color == #C47AC0
415 | slug == HNF1B-blood-sugar
415 | title == How Genetics Affects Insulin Production (HNF1B)
415 | meta_description == The HNF1B gene is crucial for insulin production. Click to learn about its link with blood sugar levels.
415 | summary == <p style="text-align:justify"><strong>Did you know there&rsquo;s a specific type of diabetes caused by mutations in the HNF1B gene? Read this post to learn more about this genetic link and get personalized tips to reduce blood sugar.</strong></p>
415 | overall_score_text == Your Blood Sugar Score (based on HNF1B gene)
415 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HNF1B-Blood-Sugar-Diabetes.jpg
415 | author_id == 9
415 | author_name == Aleksa Ristic
415 | author_title == MS (Pharmacy)
415 | author_order == 45
415 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
415 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
415 | reviewer == None
415 | medical_reviewer_id == 11
415 | medical_reviewer_name == Puya Yazdi
415 | medical_reviewer_title == MD
415 | publish_date == 2020
415 | publish_date == 10
415 | publish_date == 16
415 | avg_rating == 4.5
415 | tags_id == 801
415 | tags_name == Blood Sugar
415 | tags_id == 127
415 | tags_name == Diabetes Type 2
415 | tags_id == 834
415 | tags_name == HNF1B gene
415 | tags_id == 116
415 | tags_name == Insulin Resistance
415 | tags_id == 805
415 | tags_name == Pancreas
415 | permissions_favorite == False
415 | permissions_rate == False
415 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The HNF1B gene enables the development of different organs, especially the kidneys and pancreas.<br /><br /></strong><strong>Specific variants can reduce HNF1B activity and impair insulin function, contributing to high blood sugar.<br /><br /></strong><strong>There is a simple way to balance blood sugar levels by targeting your gene variants.</strong></span></p> <p>&nbsp;</p> <h2><strong>The HNF1B Gene &amp; Blood Sugar</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://selfdecode.com/gene/hnf1b/"><span style="font-weight: 400;">HNF1B</span></a><span style="font-weight: 400;"> gene enables the development of different organs, especially the kidneys and pancreas. Severe mutations of this gene can cause a specific type of inherited diabetes with kidney disease&nbsp; [</span><a href="https://medlineplus.gov/genetics/gene/hnf1b/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://care.diabetesjournals.org/content/31/11/e83"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Less severe variants can reduce HNF1B activity and hinder insulin production in pancreatic beta cells. They have been associated with type 2 diabetes, the primary cause of high blood sugar [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your HNF1B Results for Blood Sugar</strong></h2> <p>*3012350130404426*</p> <p><strong>Primary SNPs:</strong></p> <p><a href="https://selfdecode.com/snp/rs7501939/"><strong>rs7501939</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher blood sugar levels due to type 2 diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele likely reduces HNF1B activity</span></li> </ul> <p><a href="https://selfdecode.com/snp/rs11651755/"><strong>rs11651755</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with higher blood sugar levels due to type 2 diabetes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele likely reduces HNF1B activity</span></li> </ul> <p>*2107713372608954*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Blood Sugar</strong></h2> <p>*3181477442386422*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Maintain a Healthy Weight</strong></h4> <p><span style="font-weight: 400;">Based on human and animal data, obesity can reduce HNF1B activity in the liver and thus impair glucose metabolism [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23389544/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Being overweight or obese is the number one risk factor for high blood sugar levels, </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">, and type 2 diabetes. Even a slight weight reduction can be beneficial [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857968/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829255/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The two crucial approaches to </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> are calorie control and regular </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;">. Robust clinical evidence shows their effectiveness in improving blood glucose and insulin resistance [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10102702/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686951/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26853238/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510106/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30553010/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Maintain a healthy weight with calorie control and regular exercise to counteract your gene variants and reduce blood sugar.</span></p>
415 | content_snp_table_3012350130404426_key == 3012350130404426
415 | content_snp_table_3012350130404426_blur == True
415 | content_snp_table_3012350130404426_hidden == False
415 | content_learn_more_2107713372608954_key == 2107713372608954
415 | content_learn_more_2107713372608954_blur == True
415 | content_learn_more_2107713372608954_hidden == False
415 | content_learn_more_2107713372608954_text == Based on the variants we looked at, your HNF1B gene is associated with slightly higher blood sugar levels and diabetes rates. However, this doesn't necessarily reflect your overall risk of elevated blood sugar; it’s just one gene related to it. Maintain a healthy weight with calorie control and regular exercise to counteract your gene variants. Keep reading to learn more.
415 | content_recommendation_3181477442386422_key == 3181477442386422
415 | content_recommendation_3181477442386422_blur == True
415 | content_recommendation_3181477442386422_hidden == False
rsIDs = rs7501939,rs11651755
rsStatus = rs7501939,HNF1B,chr17,37741165,C,G,T,,27,0,Normal
rsStatus = rs11651755,HNF1B,chr17,37739849,T,C,,,21,0,Normal
