418 | id == 418
418 | category_id == 25
418 | category_order == 22
418 | category_name == Blood Sugar
418 | category_color == #C47AC0
418 | slug == TSPAN3-blood-sugar
418 | title == How Does This Cell Growth Gene Affect Blood Sugar? (TSPAN3)
418 | meta_description == TSPAN3 encodes tetraspanin-3, which regulates cell growth and movement. How might it be connected to blood sugar?
418 | summary == <p><strong><em>TSPAN3 </em>encodes tetraspanin-3, which regulates cell growth and movement. How might it be connected to blood sugar? Read on to learn more.</strong></p>
418 | overall_score_text == Your Blood Sugar Score (based on TSPAN3 gene)
418 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TSPAN3-PEAK1-Blood-Sugar-Diabetes.jpg
418 | author_id == 1
418 | author_name == Jasmine Foster
418 | author_title == BSc, BEd
418 | author_order == 36
418 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
418 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
418 | reviewer == None
418 | medical_reviewer_id == 11
418 | medical_reviewer_name == Puya Yazdi
418 | medical_reviewer_title == MD
418 | publish_date == 2020
418 | publish_date == 10
418 | publish_date == 19
418 | avg_rating == 4.5
418 | tags_id == 33
418 | tags_name == Autoimmunity
418 | tags_id == 801
418 | tags_name == Blood Sugar
418 | tags_id == 81
418 | tags_name == Diabetes Type 1
418 | tags_id == 127
418 | tags_name == Diabetes Type 2
418 | tags_id == 139
418 | tags_name == Insulin
418 | tags_id == 116
418 | tags_name == Insulin Resistance
418 | tags_id == 839
418 | tags_name == Tetraspanins
418 | tags_id == 838
418 | tags_name == TSPAN3 Gene
418 | permissions_favorite == False
418 | permissions_rate == False
418 | content_article == <h2><strong>Summary</strong></h2> <p><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> encodes tetraspanin-3. Variants of </span><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> may play a role in diabetes either through impaired insulin signalling or autoimmune reactions. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by preventing insulin resistance and reducing autoimmune inflammation.</span></p> <h2><strong><em>TSPAN3</em></strong><strong> and Blood Sugar</strong></h2> <p><em><span style="font-weight: 400;">TSPAN3 </span></em><span style="font-weight: 400;">encodes tetraspanin-3, a protein that plays a role in cell growth, development, and migration through the body into the appropriate tissues. Because of these functions, it is best studied for its potential role in cancers such as acute myelogenous leukemia, a deadly blood cancer [</span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=ShowDetailView&amp;TermToSearch=10099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://jcs.biologists.org/content/128/19/3583.long"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664079/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Association studies have found that certain </span><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> variants are more common in people with diabetes, but the reason for this link is unclear [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/22885922"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Tetraspanin-3 might have an indirect interaction with insulin. Tetraspanin-3 regulates the expression of a protein called ADAM10 in the nervous system, and ADAM10 needs insulin to break apart the longevity protein </span><a href="https://selfdecode.com/blog/article/klotho-longevity-96/"><span style="font-weight: 400;">klotho</span></a><span style="font-weight: 400;">. However, researchers don&rsquo;t know whether this interaction has any effect on insulin&rsquo;s blood sugar functions [</span><a href="https://www.sciencedirect.com/science/article/pii/S0167488916302890?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148378/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have found a couple of other clues about how tetraspanin-3 might affect blood sugar. In type 1 diabetes, people sometimes develop autoimmune antibodies against a similar tetraspanin protein, tetraspanin-7. It could be that a similar reaction exists for tetraspanin-3, but this option has not yet been explored [</span><a href="https://diabetes.diabetesjournals.org/content/65/6/1690"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><em><span style="font-weight: 400;">TSPAN3 </span></em><span style="font-weight: 400;">or </span><em><span style="font-weight: 400;">PEAK1</span></em><span style="font-weight: 400;">?</span></h3> <p><span style="font-weight: 400;">The variants in the SNP table below have been associated with multiple genes, namely </span><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">PEAK1</span></em><span style="font-weight: 400;">. Researchers aren&rsquo;t quite sure which one they &ldquo;really&rdquo; belong to; they&rsquo;re physically close enough to both genes that they could affect either one&hellip; or both of them [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30054458/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/abstract/med/22885922"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Both </span><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">PEAK1</span></em><span style="font-weight: 400;"> are genes involved in cell growth, development, and migration around the body. So, even if it turns out that one or both of these variants actually only affects </span><em><span style="font-weight: 400;">PEAK1</span></em><span style="font-weight: 400;">, the mechanism by which they affect blood sugar may be similar [</span><a href="https://www.ncbi.nlm.nih.gov/gene/10099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/gene?Db=gene&amp;Cmd=DetailsSearch&amp;Term=79834"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> encodes tetraspanin-3, which plays a role in the growth, development, and migration of cells. Its connection to blood sugar is poorly studied, but it may have something to do with insulin signalling or autoimmune inflammation.</span></span></p> <h2><strong>Your </strong><strong><em>TSPAN3</em></strong><strong> Results for Blood Sugar</strong></h2> <p>*2663890898192500*</p> <p><strong>TSPAN3 </strong><a href="http://selfdecode.com/snp/rs7177055"><strong>rs7177055</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with relatively high blood sugar [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063971/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>TSPAN3 </strong><a href="https://selfdecode.com/snp/rs7178572/"><strong>rs7178572</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with relatively higher blood sugar levels</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against high blood sugar [</span><a href="https://europepmc.org/abstract/med/22885922"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p>*4680179338049397*</p> <h2><strong>Recommendations for Controlling Blood Sugar</strong></h2> <p>*6834385023392178*</p> <p><strong>Note</strong><span style="font-weight: 400;">: The mechanism by which </span><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> affects blood sugar is currently unknown. It may interfere with insulin signalling, it may be involved in an autoimmune reaction, or there may be a completely undiscovered connection. Because the only options we know about right now are insulin signalling and autoimmunity, we have focused here on recommendations that both increase insulin sensitivity and decrease autoimmune inflammation.</span></p> <h3><strong>Avoid Cigarettes &amp; Air Pollution</strong></h3> <p><span style="font-weight: 400;">Exposure to cigarette smoke and other forms of </span><a href="https://selfhacked.com/blog/top-17-negative-health-effects-pollution/"><span style="font-weight: 400;">air pollution</span></a><span style="font-weight: 400;"> have been associated with both insulin resistance and autoimmune disease [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25635985/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17153844/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.sciencedirect.com/science/article/abs/pii/S1568997219300886"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/top-17-negative-health-effects-pollution/"><span style="font-weight: 400;">Air pollution</span></a><span style="font-weight: 400;"> (particularly traffic pollution, nitrogen dioxide, tobacco smoke, and particulate matter) is a leading cause of insulin resistance and type 2 diabetes mellitus [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25635985/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266153/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31252121/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583950/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902714/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Intermediate- and long-term exposure to pollution increases </span><a href="http://selfhacked.com/blog/intermittent-fasting/"><span style="font-weight: 400;">fasting</span></a><span style="font-weight: 400;"> glucose, glycated hemoglobin, blood fat levels, and the risk of heart disease and stroke, especially in people with type 2 diabetes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27218271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950252/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20833756/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20190657/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Smoking has been clearly associated with higher glycated </span><a href="https://selfhacked.com/blog/hemoglobin-good-bad-lab-tests-normal-values-reference-ranges/"><span style="font-weight: 400;">hemoglobin</span></a><span style="font-weight: 400;">, a marker of long-term exposure to glucose that indicates poor blood glucose control and predicts risk of type 2 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240946/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similarly, women with gestational diabetes who smoked at the beginning of their pregnancy showed higher glycated hemoglobin levels and blood sugar spikes after an oral glucose tolerance test [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26416345/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Air pollutants, including cigarette smoke, are associated with both insulin resistance and autoimmune disease. Those with detrimental </span><em><span style="font-weight: 400;">TSPAN3</span></em><span style="font-weight: 400;"> variants should be especially careful to avoid such pollutants.</span></span></p> <h3><strong>Magnesium</strong></h3> <p><span style="font-weight: 400;">Magnesium deficiency is associated with autoimmune and inflammatory diseases [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31172335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Low </span><a href="https://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">magnesium</span></a><span style="font-weight: 400;"> levels play a role in the development of insulin resistance, type 2 diabetes, and metabolic syndrome, while high intake of magnesium-rich foods such as whole grains, beans, nuts, and green leafy vegetables has been associated with a lower incidence of type 2 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470576/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549665/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24218228/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17645588/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Dietary magnesium improved insulin sensitivity and reduced fasting glucose levels in a clinical trial [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820051/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Major food sources containing magnesium are leafy green vegetables, fruits, legumes (especially soy), nuts (almonds, cashews), whole grains, red meat, and seafood. Magnesium supplements are also readily available [</span><a href="http://www.racgp.org.au/afpbackissues/2005/200508/200508woolhouse.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="http://jn.nutrition.org/content/144/1/55.long"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Magnesium deficiency may play a role in the development of insulin resistance and autoimmunity. Magnesium-rich foods contain enough to ward off deficiency in most people, but supplements are also available.</span></p> <h3><strong>Zinc</strong></h3> <p><span style="font-weight: 400;">Zinc is a vital mineral for correct immune function, and zinc deficiency is common in both autoimmunity and insulin resistance [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several meta-analyses have found that </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> supplementation may reduce blood glucose, insulin resistance, and glycated hemoglobin levels in people with obesity, diabetes (both type 1 and 2) and metabolic syndrome [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27587022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23137858/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407731/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Zinc may also decrease the severity of diabetic neuropathy (nerve </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;">), oxidative stress, and cholesterol/triglyceride levels in type 2 diabetic patients [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11229219/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11444416/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407731/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064411/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc is absolutely essential for the correct function of the immune system and has also been linked to insulin resistance. Zinc supplementation is an easy way to prevent deficiency.</span></p>
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418 | content_learn_more_4680179338049397_text == Based on the variants we looked at, your TSPAN3 gene is somewhat associated with high blood sugar. However, this doesn't necessarily reflect your overall risk of diabetes; it’s just one gene related to it. Avoiding cigarettes and air pollution and increasing intake of magnesium and zinc may help. Keep scrolling to find out more.
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rsIDs = rs7178572,rs7177055
rsStatus = rs7178572,HMG20A,chr15,77454848,A,C,G,,21,0,Normal
rsStatus = rs7177055,,chr15,77540420,G,A,,,18,11,HET
