42 | id == 42
42 | category_id == 12
42 | category_order == 9
42 | category_name == Cardiovascular
42 | category_color == #C47AC0
42 | slug == heart-health-PON1
42 | title == The Gene That Protects Your Heart (PON1)
42 | meta_description == Find out if your PON1 genes are protecting your heart and what you can do about it.
42 | summary == <p><strong>Heart disease is one of the leading causes of death in the world. Fortunately, PON1 protects your heart by clearing away fats in your blood. Certain genetic variants, however, may impact how well PON1 works. Find out if your genes are protecting your heart and what you can do about it.</strong></p>
42 | overall_score_text == Heart Score (based on PON1)
42 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/The-Gene-That-Protects-Your-Heart-PON1_JPG.jpg
42 | author_id == 8
42 | author_name == Mathew Eng
42 | author_title == PharmD
42 | author_order == 40
42 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Mathew.jpg
42 | author_intro == <p><strong>Mathew received his PharmD from the University of Hawaii and an undergraduate degree in Biology from the University of Washington.</strong></p>    <p>Mathew is a licensed pharmacist with clinical experience in oncology, infectious disease, and diabetes management. He has a passion for personalized patient care and believes that education is essential to living a healthy life. His goal is to motivate individuals to find ways to manage their chronic conditions.</p>
42 | reviewer_id == 1
42 | reviewer_name == Jasmine Foster
42 | reviewer_title == BSc, BEd
42 | medical_reviewer_id == 11
42 | medical_reviewer_name == Puya Yazdi
42 | medical_reviewer_title == MD
42 | publish_date == 2019
42 | publish_date == 9
42 | publish_date == 12
42 | avg_rating == 5.0
42 | tags_id == 138
42 | tags_name == Atherosclerosis
42 | tags_id == 137
42 | tags_name == Coronary Artery Disease
42 | tags_id == 136
42 | tags_name == HDL
42 | tags_id == 135
42 | tags_name == Heart Attack
42 | tags_id == 134
42 | tags_name == Heart Disease
42 | tags_id == 118
42 | tags_name == Pon1 Gene
42 | permissions_favorite == False
42 | permissions_rate == False
42 | content_article == <p><span style="font-weight: 400;"><strong>Note:</strong> PON1 is mentioned in the <a href="https://get.selfdecode.com/gene-reports/introductory/">Introductory Gene Report</a>, along with many other genes. If you're looking for a comprehensive report about your genes, check it out.</span></p> <h2><span style="font-weight: 400;">What Is The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Gene?</span></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene encodes a protein that is also called </span><a href="https://selfhacked.com/blog/about-pon1-and-natural-ways-to-increase-it/"><span style="font-weight: 400;">PON1</span></a><span style="font-weight: 400;">. The protein PON1, which is short for paraoxonase 1, is an enzyme that hydrolyzes (breaks apart) many different types of chemical bonds [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This ability to break down various molecules is useful for when the body needs to remove certain harmful compounds. For example, PON1 breaks apart oxidized fats that could otherwise lead to heart disease, and it can also </span><a href="https://selfhacked.com/blog/the-science-of-detoxification/"><span style="font-weight: 400;">detoxify</span></a><span style="font-weight: 400;"> toxic compounds called organophosphates [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene encodes the protein PON1, which protects the body by breaking down harmful compounds.</span></span></p> <h3><span style="font-weight: 400;">How Does PON1 Protect The Heart?</span></h3> <p><span style="font-weight: 400;">PON1, which is found inside </span><a href="https://selfhacked.com/blog/hdl-cholesterol/"><span style="font-weight: 400;">HDL</span></a><span style="font-weight: 400;"> (your good cholesterol), helps the heart by breaking apart oxidized fats in your bloodstream. If these fat compounds are not controlled, they can develop into plaque buildup that clogs the blood vessels, which is known as atherosclerosis. This can lead to several heart disorders like coronary artery disease and heart attacks [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28667557"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary research suggests that increasing PON1 activity results in lower atherosclerosis, which ultimately leads to a lower risk of developing heart disease in the future [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22030099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">PON1 protects the heart by breaking down fats in the blood, which could otherwise turn into dangerous plaque buildup.</span></p> <h2><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Gene and Heart Health</span></h2> <p><span style="font-weight: 400;">There are two main SNPs in the </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> gene that influence the heart-protective effects of PON1: </span><strong>rs662</strong><span style="font-weight: 400;"> and </span><strong>rs854560</strong><span style="font-weight: 400;">. While research on both SNPs has revealed some conflicting results, the majority of studies seem to indicate that specific gene variants can protect your heart better [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A recent, large analysis of 64 studies including over 53,000 people gives us perhaps the best insight on </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;">&rsquo;s effect on the heart. In rs662, they found that people with the &ldquo;C&rdquo; allele may have lower rates of both heart attacks and coronary artery disease compared to those without it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to the same analysis, people who have a &ldquo;T&rdquo; allele at rs854560 may also have lower rates of developing heart disease, but only in European and Asian groups [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Its important to remember that these findings have been inclusive and more research is needed before we can draw any firm conclusions on these SNPs and heart health.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The &ldquo;C&rdquo; allele in rs662 and the &ldquo;T&rdquo; allele in rs854560 may protect you from developing heart disease as you age. But more reseach is needed.&nbsp;</span></p> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Results for Heart Disease</span></h2> <p>*3497323554716769*</p> <p><strong>Primary SNP:</strong></p> <p><strong>PON1 rs662</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; allele doesn&rsquo;t increase your risk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; allele increases your risk of heart disease</span></li> </ul> <p><span style="font-weight: 400;">Population Frequency</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">24% of the world population have "TT"</span></li> </ul> <p><strong>PON1 rs854560</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; allele doesn&rsquo;t increase your risk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; allele increases your risk of heart disease</span></li> </ul> <p><span style="font-weight: 400;">Population Frequency</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">68% of the world population have "AA"</span></li> </ul> <p><span style="font-weight: 400;">Note:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">In rs854560, the risk allele &ldquo;A&rdquo; appears to only affect Europeans and Asians, the allele does not increase risk in other groups</span></li> </ul> <p>*2362487518351395*</p> <h2><span style="font-weight: 400;">How Can You Improve Your </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> Genotype?</span></h2> <p><span style="font-weight: 400;">Before making any lifestyle, diet, and supplement changes like the ones below, make sure to talk to your doctor. Together, you can find the right strategies for you.</span></p> <p><span style="font-weight: 400;">*2892466295675426*</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">There are several lifestyle changes you can make to significantly boost your PON1 activity. You should try to:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Quit smoking: the oxidant compounds in cigarettes can inhibit PON1, and smokers are at greater risk of heart disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390564/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK53012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Exercise more: it activates </span><a href="http://selfhacked.com/blog/ppargamma-role-weight-gain-inflammation-natural-activators/"><span style="font-weight: 400;">PPAR-gamma</span></a><span style="font-weight: 400;">, a receptor that increases </span><em><span style="font-weight: 400;">PON1</span></em><span style="font-weight: 400;"> expression; regular exercise is strongly associated with lower risk of heart disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214038/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25735253"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25180827"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172294/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fix any inflammation issues: inflammatory compounds like </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1b</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;"> can reduce the expression and activity of PON1. Inflammation is also linked to atherosclerosis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14511766"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22222492"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25037581"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Research shows that exercising, quitting cigarettes, and reducing inflammation can significantly improve your PON1 function and reduce your risk of heart disease.</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">According to research, many different types of foods can increase PON1 activity and reduce the risk of heart disease. These foods primarily work as antioxidants, which stop </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidants</span></a><span style="font-weight: 400;"> from inhibiting PON1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456308/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Foods and diets that have been shown to protect the heart and increase the activity of PON1 include:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The Mediterranean diet is strongly associated with a lower risk of heart disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488773/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24261534"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29678447"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">Extra virgin olive oil</span></a><span style="font-weight: 400;"> may reduce the risk of death from heart disease by as much as 48% [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18585720"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29141571"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">Green tea</span></a><span style="font-weight: 400;"> has been shown to lower the risk of heart disease, heart attacks, and strokes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26318390"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123419/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Fish oil</span></a><span style="font-weight: 400;"> (</span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3 fatty acids</span></a><span style="font-weight: 400;">) can reduce the risk of coronary artery disease and cardiac death. This is, in part, due to their ability to reduce fats in the blood [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120510/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22222492"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217043/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28531360"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/blueberries-health-benefits/"><span style="font-weight: 400;">Blueberries</span></a><span style="font-weight: 400;"> may reduce blood pressure and cholesterol in obese people, both of which are risk factors for heart disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924596/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068482/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/pomegranate/"><span style="font-weight: 400;">Pomegranate</span></a><span style="font-weight: 400;"> significantly decreases blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27888156"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;">, a polyphenol found in fruits and vegetables, may protect against heart disease risk factors, like diabetes, high blood pressure, and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214562/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29966915"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25915608"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">However, it&rsquo;s important to note that some of these findings are based on animal or cell studies. It&rsquo;s not always clear what effect may be seen in humans [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Foods rich in antioxidants like green tea, blueberries, and fish oils can increase the activity of PON1, while also reducing your risk of heart disease.</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">Several supplements have been shown to increase PON1 activity and improve heart health. Similar to the food recommendations, these supplements primarily boost PON1 by acting as an antioxidant [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/need-know-vitamin-c-32-science-based-health-benefits/"><span style="font-weight: 400;">Vitamin C</span></a><span style="font-weight: 400;"> deficiency is linked to a higher risk of death from heart disease. Vitamin C may also improve your cholesterol and blood vessel function [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000725/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/everything-need-know-grapeseed-extract-references/"><span style="font-weight: 400;">Grape seed extract</span></a><span style="font-weight: 400;"> may improve your blood pressure and blood vessel function, both of which can be risk factors for heart disease if not properly controlled [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21802563"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082891/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> may protect against heart disease by lowering blood pressure, decreasing total cholesterol, and improving the function of HDL (your good cholesterol) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28192240"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29020971"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19233493"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> may reduce the risk of heart disease and heart failure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903941/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15458977"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882663/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">However, many of these supplements were only studied in animal or cell studies; they may not have the same effect in humans [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29020971"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplements that contain antioxidants like vitamin C, curcumin, and grape seed extract increase PON1 activity and may improve heart health.</span></p>
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42 | content_learn_more_3497323554716769_text == Based on the variants we looked at, your PON1 gene makes you somewhat more likely to develop heart disease. However, this doesn't necessarily reflect your overall risk of heart disease, just one gene related to it. Exercise and antioxidant foods/supplements may help. Keep scrolling to find out more.
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rsIDs = rs662,rs854560
rsStatus = rs662,PON1,chr7,95308134,T,A,C,G,28,0,Normal
rsStatus = rs854560,PON1,chr7,95316772,A,C,G,N,25,0,Normal
